Material Safety Data Sheet for Tert-Butyl Chloroacetate

Identification

Product Name: Tert-Butyl Chloroacetate
Chemical Formula: C6H11ClO2
CAS Number: 107-59-5
Synonyms: Chloroacetic acid tert-butyl ester
Recommended Use: Synthesis of pharmaceuticals and organic compounds
Supplier: Manufacturer or laboratory supply outlet with appropriate safety protocols
Contact Information: Emergency phone numbers available on vendor-specific MSDS
Restrictions: Industrial, laboratory and research use only

Hazard Identification

Classification: Acute Toxicity (Category 4, Oral), Skin Irritation (Category 2), Eye Irritation (Category 2A)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and serious eye irritation, may be harmful if inhaled, causes respiratory tract irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing vapors, wear protective gloves, avoid contact with skin, eyes, and clothing, wash thoroughly after handling, do not eat, drink or smoke near this chemical
Potential Health Effects: Ingestion may cause nausea and vomiting, inhalation may result in coughing and shortness of breath, skin contact may provoke redness, eye contact may cause burning and watering

Composition / Information on Ingredients

Chemical: Tert-Butyl Chloroacetate
Concentration: >98%
CAS Number: 107-59-5
Impurities: Trace organic or inorganic solvents that may be present from manufacturing or storage
Other Components: No listed hazardous components other than the main chemical
Stabilizers/Additives: No known additives present

First Aid Measures

Inhalation: Move affected person to fresh air, keep calm and warm, seek medical advice if symptoms persist, provide oxygen if available
Skin Contact: Remove contaminated clothing, wash affected skin with soap and water for at least 15 minutes, consult a physician if irritation continues
Eye Contact: Flush immediately with plenty of water for at least 15 minutes, keep eyelids wide open, remove contact lenses if present and easy to do, get medical attention
Ingestion: Rinse mouth with water, do not induce vomiting, never give anything by mouth to an unconscious person, seek medical advice immediately
Special Treatment: Symptomatic treatment as required, no specific antidote known

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, CO2, foam, water spray (do not use direct water jet)
Specific Hazards: Vapors may form explosive mixtures with air, combustion releases toxic fumes (hydrogen chloride, carbon oxides)
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective clothing
Firefighting Instructions: Stay upwind, prevent runoff from entering drains, cool fire-exposed containers with water spray
Decomposition Products: Hydrogen chloride, carbon monoxide, carbon dioxide

Accidental Release Measures

Personal Precautions: Evacuate unnecessary personnel, use proper personal protective equipment including gloves, goggles, and respiratory protection
Environmental Precautions: Prevent spillage from entering waterways, soil, or drains
Containment: Absorb with inert material such as sand or earth, collect in appropriate containers for disposal
Cleaning Methods: Provide ventilation, use non-sparking tools, wash affected area with water
Reporting: Notify authorities if major release has caused environmental contamination

Handling and Storage

Safe Handling: Operate in a well-ventilated area, avoid inhalation or contact with skin and eyes, use protective gear
Hygiene Practices: Wash hands thoroughly before eating, drinking, or smoking, change contaminated clothes immediately
Storage Conditions: Store in tightly closed containers, keep in a cool, dry, ventilated place, protect from heat and direct sunlight
Incompatibilities: Strong bases, strong oxidizing agents, acids
Special Considerations: Store away from foodstuffs and incompatible materials, appropriate signage and secondary containment required

Exposure Controls and Personal Protection

Exposure Limits: No specific occupational limits established, handle in accordance with general chemical hygiene practices
Engineering Controls: Local exhaust ventilation, eye wash stations, safety showers
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles, protective lab coat, respiratory protection where vapors may be released
Additional Measures: Ensure appropriate fit of personal protection, replace damaged protective gear promptly
Hygiene: Wash thoroughly after handling, before breaks, and at the end of the workday

Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid
Odor: Characteristic, pungent
Boiling Point: 140-142°C
Melting Point: -30°C
Flash Point: 46°C (closed cup)
Vapor Pressure: 5.0 hPa at 20°C
Solubility: Slightly soluble in water, soluble in most organic solvents
Density: 1.07 g/cm³
pH: Not applicable
Viscosity: Not available
Partition Coefficient (log Kow): Approximately 1.5

Stability and Reactivity

Chemical Stability: Stable under normal conditions of storage and handling
Hazardous Reactions: May react violently with strong bases, strong oxidizers
Conditions to Avoid: Heat, flames, sparks, direct sunlight, moisture
Incompatible Materials: Strong bases, oxidizing agents, acids
Decomposition Products: Emits hydrogen chloride and carbon oxides on combustion or high-temperature decomposition

Toxicological Information

Acute Toxicity: LD50 (Oral, rat): 1400 mg/kg; data on skin and inhalation toxicity limited, can be irritating
Skin Corrosion/Irritation: Causes skin irritation, may provoke redness or rash
Serious Eye Damage/Irritation: Causes serious eye irritation, can lead to watering and pain
Respiratory or Skin Sensitization: No evidence found for sensitization
Chronic Toxicity: Long term exposure data not well documented, repeated exposures may increase risk of dermatitis or other irritation
Mutagenicity/Carcinogenicity: Not listed as a known carcinogen or mutagen by IARC, NTP, or OSHA
Other Effects: May cause nausea, headache, and dizziness after high exposure

Ecological Information

Ecotoxicity: Harmful to aquatic life, potential for adverse effects in aquatic organisms not fully tested
Persistence and Degradability: Expected to be moderately biodegradable based on chemical structure
Bioaccumulative Potential: Has potential due to moderate log Kow but data limited
Mobility in Soil: Not highly mobile, likely to bind to soil particles
Other Adverse Effects: Should not be allowed to enter watercourses, risk of long-term effects in environment

Disposal Considerations

Disposal Methods: Dispose in accordance with local, regional, national, and international regulations; incineration under controlled conditions preferred
Contaminated Packaging: Rinse containers three times, dispose as hazardous waste
Other Recommendations: Do not discharge into drains, surface water, or soil
Waste Codes: Consult applicable regulations for correct code assignment

Transport Information

UN Number: 2810
Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains tert-butyl chloroacetate)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Labels: Toxic
Marine Pollutant: Not classified as a marine pollutant
Special Precautions: Protect containers from physical damage, ensure chemical is stored upright during transit
Regulatory Requirement: Shipping documents must correctly describe chemical and meet regulatory standards

Regulatory Information

US Regulations: Subject to TSCA, SARA 313, and CERCLA where applicable
EU Regulations: Classified under REACH and CLP regulations, appropriate pictograms and risk phrases needed
Canada: Included in DSL/NDSL as appropriate
Other National Inventories: Check applicable regulations in each jurisdiction
Label Elements: GHS-compliant labels required for storage and use
Workplace Safety: Adapt local employee training, hazard communication, and workplace labeling practices to comply with local regulation