Tert-Butyl Chloroacetate: A Closer Look at a Critical Chemical
Historical Development
Chemists have worked with esters like tert-butyl chloroacetate for decades, probably stretching back to the early explorations of chloroacetic acid derivatives in the late nineteenth and early twentieth centuries. Researchers studying ways to introduce halogen groups into carbon chains stumbled on a need for controllable, reactive intermediates. Tert-butyl chloroacetate became essential because its tert-butyl group brought stability for transport and storage, but its chloroacetate functionality offered high reactivity in synthesis. Chemical catalogs list it in their pages from at least the 1950s, evidence of its steady use by generations of scientists exploring everything from drug synthesis to polymer engineering.
Product Overview
Tert-butyl chloroacetate, known by chemists in the lab as a simple ester, opens up a world of possibilities in chemical synthesis. The molecule combines the tert-butyl group with a chloroacetyl core, giving both steric bulk and an activated halide. This dual nature means you’ll find it on orders from manufacturers making specialty chemicals, as well as on benches in research labs. It usually comes as a clear liquid with a sharp smell, packed in glass bottles or jugs lined to protect its purity and prevent reactions. Every time I’ve handled it, suppliers have stressed tight seals and careful measuring—exposure to air or water can set off slow degradation or unwanted side reactions.
Physical & Chemical Properties
With a boiling point somewhere around 140-143°C, tert-butyl chloroacetate holds up under moderate heat. Its density comes in just above water, floating near 1.07 g/cm³, which fits with most other similar organic esters. The molecule does not dissolve easily in water but mixes well in ethers, acetone, and most hydrocarbons. As a chloroacetate, it reacts strongly with bases and nucleophiles. A chemist handling this liquid needs to watch for signs of hydrolysis—any moisture in the atmosphere slowly liberates tert-butyl alcohol and chloroacetic acid, both of which alter the chemistry if purity isn’t maintained. Its volatility and odor signal care during open transfers.
Technical Specifications & Labeling
Labels on bottles give more than just a name and formula. Purity holds critical value—commercial products usually specify more than 98% tert-butyl chloroacetate, with controlled limits on acid content, water, and related esters. The correct UN and hazard codes appear alongside storage guidance, usually recommending cool, dry places with a warning for its irritant and lachrymatory effects. Each order ships with a Certificate of Analysis detailing lot number, actual purity, and information about specific impurities (such as tert-butyl alcohol, chloroacetic acid, and water). Chemical suppliers also mark bottles with the molecular formula C6H11ClO2, batch references, and the CAS number 107-59-5, aligning with international identification standards.
Preparation Method
Synthesizing tert-butyl chloroacetate generally starts from chloroacetic acid, which reacts with tert-butanol in the presence of a dehydrating agent. Acid catalysis typically promotes the esterification process, with concentrated sulfuric acid among the favorites. In an industrial context, continuous processes use careful temperature control and reflux to maximize the yield while stripping out water and managing the acidity. Suppliers scale-up with distillation under reduced pressure to separate the ester from unreacted ingredients, often recycling solvents and minimizing waste. This method, although reliable, brings risks like the production of acidic vapors and the need for robust containment. The waste stream includes spent acids and traces of halogenated byproducts, which pushes for greener approaches in modern chemical engineering.
Chemical Reactions & Modifications
More than just a starting material, tert-butyl chloroacetate finds itself in a range of organic syntheses. The chlorine atom serves as a perfect leaving group, so nucleophiles—everything from amines to thiols—swap in to build more complex molecules. This feature shows up in pharmaceutical discovery, where chemists introduce amino or thioester groups for structure-activity exploration. I’ve watched medicinal chemists convert tert-butyl chloroacetate into oxazoles and related heterocycles, all the while relying on its steric protection for site-selectivity. The tert-butyl ester itself comes off under mild acidic conditions, so late-stage deprotection in multi-step syntheses avoids harsh environment and preserves sensitive functional groups in complicated molecules. Modifying the ester through transesterification or coupled reactions, researchers bring out analogs needed for fine-tuning drug candidates or specialized materials.
Synonyms & Product Names
Ask a chemist about tert-butyl chloroacetate and they might call it by more than one name. Some use the IUPAC designation: 2-chloroacetic acid tert-butyl ester. Others stick with easy shorthand like Chloroacetic Acid tert-Butyl Ester or the registry code, 107-59-5. Lab records show abbreviations such as t-BuOCOCH2Cl or TBCA for quick note-taking. Packaging and catalogs sometimes display alternative spellings: tert-Butyl 2-chloroacetate or even tert-Butyl Monochloroacetate. Each synonym points to the same esterification product—knowing them all proves essential when cross-referencing international suppliers or regulatory documents.
Safety & Operational Standards
Experience teaches respect for compounds like tert-butyl chloroacetate. Even a small splash can irritate skin or eyes, and its vapors draw instant tears and coughing. Access to a fume hood feels non-negotiable, along with nitrile gloves and snug goggles. Standard operating procedures spell out response actions for spills—neutralizing with sodium bicarbonate, venting to safe disposal, never washing down ordinary drains. Material Safety Data Sheets (MSDS) list it as harmful if inhaled or ingested, with special mention for its risk to respiratory passages. I’ve seen teams enforce buddy-systems during weighing or large-scale transfers, making sure one person always records batch use in case of emergencies. For warehouse storage, facilities invest in inert gas blanketing and corrosion-resistant shelving because the ester attacks many common plastics and metals over long storage.
Application Area
Chemists looking for an alkylating agent or a masked acetic acid function turn to tert-butyl chloroacetate. In pharmaceuticals, this compound often acts as a key intermediate on the way to more advanced structures—antiviral nucleosides, amino acid derivatives, and synthetic peptides, among others. Agrochemical researchers rely on it to make chloroacetylated derivatives that demonstrate fungicide or herbicide activity. It also helps in producing specialty polymers where chlorine introduction tailors performance or degrades in predictable ways. The tert-butyl group’s ability to protect carboxylic functions lets researchers stage complex sequences, delaying final acid release until late in synthetic pathways. A good fraction of patents for new drugs or crop chemistry feature tert-butyl chloroacetate in the first or second step, a testament to its practical versatility.
Research & Development
Continuous improvement drives the production and application of tert-butyl chloroacetate. Researchers keep searching for greener, cleaner synthesis routes that cut down on halide waste or acidic runoff. Teams explore the use of enzymes or recyclable solid acids to catalyze reactions, hoping to boost selectivity and yield with less environmental toll. In drug discovery labs, chemists design new molecular frameworks using tert-butyl chloroacetate for its controllable reactivity, with journals filling up with procedures and yield data. Regulatory pressure motivates better tracking and documentation—from automated batch recording to advanced analytical methods like HPLC and GC-MS for quality control. Cross-disciplinary teams increasingly share findings at conferences, blending expertise in physical chemistry, toxicology, and industrial engineering to push boundaries and solve persistent bottlenecks.
Toxicity Research
Safety researchers document the hazards of tert-butyl chloroacetate with care. Reports draw clear lines showing its effect as an eye, skin, and respiratory irritant, but studies on chronic toxicity remain limited. In my own lab experience, a single accidental fume burst drove even the most seasoned chemist out of the room, coughing and blotting red eyes. Animal studies point to moderate acute oral toxicity, while long-term outcomes haven’t attracted major scrutiny compared to other industrial chemicals. Environmental persistence raises questions—runoff containing esters like this can break down into chloroacetic acid, which presents ecological risks for water systems. Regulatory frameworks require clear labeling and disposal records, and hazardous materials response teams practice drills with this compound in simulated spill events. As green chemistry advocates gain ground, expect toxicity studies to dig deeper, not just into direct toxicity but also breakdown products affecting environmental safety.
Future Prospects
Looking ahead, tert-butyl chloroacetate stands poised for both adaptation and challenge. Cleaner synthesis and secure containment should reduce its environmental footprint. Advances in catalysis might lower required energy inputs and shrink impurity profiles. Pharma industries demand greater purity and more reliable sourcing, so traceability and digital batch tracking will become routine. Synthetic chemists bet on new applications—complex therapeutic agents, next-generation agricultural chemicals, polymers with customizable breakdown profiles. At the same time, regulatory shifts toward reduced hazardous waste mean some traditional uses could retire in favor of safer, biodegradable alternatives. The chemical’s foundational utility, though, ensures it remains in the synthetic chemist’s toolbox for years to come, provided ongoing commitment to safety, sustainability, and better toxicity data.
The Unsung Tool in Chemical Synthesis
Tert-Butyl Chloroacetate shows up in a lot of labs, but you won’t find its name making headlines. Chemists rely on it for the way it helps make bigger, more complicated molecules. Take pharmaceuticals as an example—this chemical pops up during the process of building active drug ingredients. It works as a protected building block, and, honestly, that saves headaches later on because it lets chemists add and remove certain parts of a molecule with way less trouble.
Why Protection Matters in Chemistry
In organic chemistry, timing often means everything. I’ve seen projects stall out because a reaction went offtrack, rearranging atoms you’d rather leave alone. Protecting groups like the tert-butyl piece in Tert-Butyl Chloroacetate help prevent those curveballs. They block certain chemicals from getting too friendly with neighboring parts, so chemists can pick and choose which reactions happen at which time. Later, that block can come off with a specific step, leaving the rest of the molecule untouched.
Role in Making Pharmaceuticals
Drug makers use Tert-Butyl Chloroacetate because it lets them put together drug candidates without unwanted byproducts. This matters, since even a little contamination can send a new pill back to square one. The chemical helps chemists attach specific side chains to a base structure. Once those attachments are locked in, they’ll remove the tert-butyl protective cover. Precision like this supports research and development for everything from antibiotics to heart medicines.
Not Just for Big Pharma
Outside the world of new medicines, specialists reach for Tert-Butyl Chloroacetate when making specialty chemicals, advanced polymers, and agrochemicals. All it takes is a reliable way to build carbon atoms in specific arrangements. For working chemists, the compound saves time, trims costs, and increases chances of a clean yield. In the end, crops might grow stronger with fewer side effects, and plastics can get tailored properties that work better for, say, auto parts or electronics.
Safety Isn’t Just a Footnote
Not every innovation comes without risk. I remember days spent double-gloving and making sure the fume hood’s alarms stayed silent. Tert-Butyl Chloroacetate gives off fumes and can cause burns. Proper handling isn’t optional; it’s essential for keeping the workplace safe. Regular training, careful storage, and keeping emergency gear within reach protect both staff and the environment. The chemistry may be exciting, but safety takes priority every step of the way.
Reducing Waste and Improving Sustainability
Every bottle of Tert-Butyl Chloroacetate used in the lab generates some waste. I’ve seen teams invest in capturing and recycling byproducts to cut down on what hits the drain. Companies with an eye for the long term partner with environmental engineers to find cleaner ways to process or dispose of leftovers. Innovative methods can also return used chemicals to a reusable state. Cleaning up the synthesis process means less pollution—and less headache—for everybody.
The Value of Collaboration
Progress speeds up when folks from different backgrounds talk to each other. Chemists, process engineers, and safety specialists bring together different viewpoints. That kind of teamwork makes using chemicals like Tert-Butyl Chloroacetate less risky and more productive. The more people share expertise, the more efficiently new products can reach patients and consumers—without cutting corners on responsibility.
What You Need to Know About Tert-Butyl Chloroacetate
In the world of organic chemistry, names start sounding like tongue-twisters once you dig deeper into synthetic compounds. Tert-butyl chloroacetate rolls off the tongue in a way that makes it unforgettable to anyone who has mixed chemicals in a lab. The chemical formula for this quirky compound is C6H11ClO2. Each part of this formula spells out precisely what you get: six carbons, eleven hydrogens, one chlorine atom, and two oxygens. No tricks, just a straightforward tally that can change the course of a whole lab’s reaction plan.
Chemical Structure and Uses
Tert-butyl chloroacetate doesn’t just pop up in advanced textbooks; I’ve seen it roll right out of flasks during real-world syntheses. This molecule contains a tert-butyl group hooked to a chloroacetate moiety. If you break it down, you get a classic chloroacetic acid backbone where a bulky tert-butyl group shields a part of the molecule. That extra bulk isn’t just for show. In the lab, it tamps down reactivity in a smart way, making tert-butyl chloroacetate a popular choice in organic syntheses that need a gentle hand. Most often, you’d find it serving as an intermediate, especially when there’s a need to attach or protect a carboxylic acid functional group temporarily so that other transformations can happen cleanly.
Why Precision in Chemical Formulas Matters
Miscount the atoms in these formulas and things can go sideways fast. Early in my chemistry days, mixing up tert-butyl chloroacetate with n-butyl chloroacetate (which swaps out tert-butyl for a straight-chain butyl group) led to entirely different reaction outcomes. Small changes in structure have real-world consequences. Being able to read and write chemical formulas is no empty exercise—mitigating lab accidents, managing costs, and getting the intended product all start with the correct combination of atoms.
What Supports This Compound’s Value?
The presence of both a reactive chlorine and a protected carboxyl group earns tert-butyl chloroacetate its place in pharmaceutical and agrochemical research. In these settings, protecting groups simplify lengthy syntheses. Publications in journals like the Journal of Organic Chemistry and the Journal of Medicinal Chemistry keep highlighting this compound’s reliability as a stepping stone toward more complex molecules. Tight regulations on sourcing, storage, and use also show up in global chemical safety guidelines. Researchers value accuracy, not just to avoid regulatory snags, but to ensure reproducibility—a bedrock of scientific credibility.
Tackling Safety and Environmental Concerns
No chemical comes without baggage. Tert-butyl chloroacetate poses risks that deserve attention. Inhalation or skin contact can irritate, and improper disposal could impact local water systems. In labs I’ve worked, following strict protocols is non-negotiable: proper ventilation, gloves, eye protection, and licensed chemical waste disposal firms come into play. The chemistry industry keeps tightening rules on solvents and reagents, encouraging safer alternatives and more responsible practices. Innovation in green chemistry aims for less hazardous substitutes when possible, but for now, compounds like tert-butyl chloroacetate remain essential for demanding syntheses.
Room for Safer Solutions
Limiting waste and exposure to risky chemicals always sits at the forefront. Today, research focuses on developing milder protection methods that use less toxic reagents and generate fewer byproducts. Automation, dose minimization, and alternative protective groups all contribute to a forward-looking approach. These efforts anchor trust—not just in what’s produced, but in the knowledge that people and the environment stand at the center of every calculation.
Respect for Chemistry in Everyday Practice
Tert-Butyl Chloroacetate makes itself known in the lab as a sharp-smelling liquid, a staple in making pharmaceuticals and specialty chemicals. Working with this compound means taking responsibility for both safety and effectiveness, and that always starts with storage. It's easy to lose sight of these basics, but real problems start when they’re overlooked. I’ve seen peace in the lab give way to chaos just because a reagent got stashed in the wrong spot or in the wrong kind of bottle.
Why Storage Can’t Be an Afterthought
Tert-Butyl Chloroacetate reacts with water, and it doesn’t play nice with strong bases or acids. Ongoing moisture exposure triggers decomposition. It gives off hydrochloric acid vapors that burn the nose and corrode metal surfaces, and the process speeds up in warmth or sunlight. Forgetting proper storage turns a helpful chemical into a health hazard. I remember once opening a cabinet and finding a leaky bottle — the smell alone was a warning. Avoiding that kind of mess means simple habits count for a lot.
Simple Rules for Safe Storage
Glass with a good seal stands up best to its vapor and doesn’t corrode, so most labs keep these bottles on hand. Polyethylene on its own can be risky — tert-butyl chloroacetate chews through many plastics, especially if a cap isn’t well-fitted.
Shut the bottle tightly every time, no matter how long you plan to have it out. Even a few minutes with the lid off means more fumes and faster breakdown. Keeping it dry is key — humidity encourages contamination and breakdown. I make a habit of returning the bottle to a dessicator or a tightly sealed cabinet with fresh drying agents.
A cool, dark cabinet offers real protection. Direct sunlight or the radiant heat off a bench causes pressure to build up inside bottles. On days when the lab gets hot, mistakes happen faster, so temperature control really matters. If the chemical must be shared between labs, I label it with the date it was opened to track its age; breakdown products play tricks on experimental results, and batches past their prime often go unnoticed until someone’s reaction fails.
Recognizing Personal Safety and Environmental Duty
Gloves and goggles aren’t overkill for handling tert-butyl chloroacetate — they help avoid skin splashes and eye irritation. Chemical fume hoods remain my line of defense against inhalation. Vapors from this ester accumulate quickly, and breathing them isn’t worth the risk. In my experience, poorly ventilated spaces turn a simple transfer into an emergency.
Disposal matters just as much. Spills and old containers shouldn’t end up down the drain; I rely on professional chemical waste disposal services to handle this liquid safely. Mishandling run-down stocks costs money, and the risk to our local environment just isn’t something to downplay.
Staying Organized Pays Off
An organized storage system cuts down on mix-ups, leaks, and waste. Careful tracking means fewer surprise shortages and safer working conditions. Over the years, a little planning in storage has proven to be the best insurance against both lost productivity and real danger. It’s easy to write another lab rule; actually sticking to good habits protects people and preserves the value of every ounce of material.
Recognizing the Risks First
Tert-Butyl Chloroacetate turns up in labs connected to pharmaceuticals, agrochemicals, and a few other specialties. It catches attention for its role in chemical synthesis, but some overlook the dangers it brings. This chemical carries a threat: its vapors and liquids can burn the eyes, irritate skin, and trigger real health issues if not treated with respect. My work in small research labs taught me early that a strong safety culture makes the difference between steady progress and rushed hospital visits.
Personal Protection Really Counts
Nobody walks into a lab with this compound in shorts and sandals. Splash-resistant lab coats and chemical goggles are my uniform. Thick nitrile gloves form my barrier against accidental splashes that deliver burning pain. Open shoes or bare ankles mean fast trips to an eye wash or emergency shower — and chemical burns linger for a long time. I keep extra pairs of gloves within reach, since nobody wants to fumble for safety gear under stress.
Good Air Makes a Safer Lab
Tert-Butyl Chloroacetate throws off fumes that can choke or sting. Proper ventilation stops headaches and lung irritation. I keep every operation with this chemical inside a fume hood, no exceptions. The fume hood shields not just my lungs, but anyone else walking through. Filters stay clean, air flow gauges get checked every day, cover glass always stays low. If the air feels heavy, I wrap things up quickly and report it — delays now mean fewer regrets later.
Storage and Labeling Matter Every Day
Tert-Butyl Chloroacetate sits locked away in a cool, dry cabinet. Acids, bases, and other reactive compounds never share a shelf with it. Clear labeling with hazard warnings, date received, and my name tells everyone what’s inside each bottle. People have ended up in the ER from grabbing an unlabeled bottle in a hurry. I learned to double-check every label, even if it takes ten seconds that the clock says I “don’t have.”
Spill Cleanups Demand Quick, Calm Action
Spills don’t wait for a convenient time. My spill kit gets checked as often as my pipettes. I keep absorbent pads, neutralizers, gloves, goggles, and a copy of the SDS (safety data sheet) handy. If a break happens, I clear everyone out, block off the area, slip on fresh gloves, and clean up with steady hands. Property damage always beats personal injury. Once, a new intern tried to mop up a spill with a paper towel — he learned fast that standard cleaning gear melts right through.
Training Makes All the Difference
People entering a lab get more than a tour; they watch seasoned chemists handle real risks. We practice safety drills every few months, going through scenarios that involve this kind of hazardous chemical. Repetition burns the right response into muscle memory. Training updates follow new research or incident reports, because stubborn habits don’t help when safety standards evolve.
Building a Culture of Responsibility
Handling Tert-Butyl Chloroacetate safely means respect for the chemical and care for your teammates. Sharing stories of near misses and actual accidents pushes everyone to take precautions seriously. If one person cuts corners, others could pay the price. Everyone in the lab plays a part in calling out unsafe shortcuts and setting the pace for better habits. The reward is fewer injuries, smoother workflows, and a clear conscience during every shift.
The Real Stakes with Chemical Grades
Anyone who’s spent time in a chemistry lab knows that purity isn’t a side issue. With reagents like tert-butyl chloroacetate, the stakes run higher than most outside the field realize. This isn’t just some obscure industrial solvent. Scientists use it to build more complicated molecules, and drug companies lean on it during key stages in making pharmaceuticals. Purity shapes the outcome. If you’ve ever watched a reaction fizzle or a purification drag on because of an unexpected impurity, you know what a headache that brings.
Grades on the Market
Suppliers typically offer tert-butyl chloroacetate in a few distinct grades. Technical grade usually shows up for less demanding applications—think large-scale industrial processes where a few stray impurities won’t throw things completely off track. High-purity or laboratory grades, on the other hand, aim at researchers and companies making ingredients for medicines or electronic devices, where anything less than “spotless” spells trouble. Analytical grade can show up for especially demanding laboratory work.
Why Bother with Purity?
I remember a project that stumbled just because of trace impurities from a batch of reagents. For those working in pharmaceuticals, a rogue impurity might mean a botched synthesis or a batch that won’t meet regulatory standards. This isn’t just about profits or wasted time. Impurities can actually threaten patient safety if they follow the product through to the end. That’s why chemists obsess over specs, ask for certificates of analysis, and probe for impurities before committing to new batches. The US Pharmacopeia and similar organizations keep strict lists of what’s allowed—and what isn’t.
The Science of Testing
Labs don’t just trust the label. Gas chromatography and NMR spectroscopy help weed out batches with unexpected add-ins. In pharmaceutical or electronics applications, these steps are non-negotiable. A single percent of a foreign material might sound small, but synthesis often multiplies problems. Over time, chemists see just how fast issues spiral if a small amount of impurity reacts or interferes. I’ve watched a supply chain grind to a halt over a 0.1% contaminant because it wouldn’t wash out, forcing us to toss costly intermediate products.
Who Sets the Bar?
Regulators and industry giants draw hard lines when it comes to purity. Pharmaceutical companies operate under GMP (Good Manufacturing Practice) guidelines, and electronics manufacturers have their own strict tolerances. Lab suppliers respond by offering full disclosure: data sheets, batch analysis, and sometimes third-party verification. Skipping these steps sometimes leads to failed audits or product recalls. Nobody wants that scenario.
Ways Forward
Stricter quality control and transparency from suppliers can solve a lot of the headaches researchers face. In my experience, clear communication between supplier and end user about purity requirements goes a long way. It pays to invest in testing protocols within the lab, too—double-checking source materials before plunging into big projects. Shared databases and fast access to batch histories would help companies catch issues before they cause costly delays.
Practical Takeaway
Ignore purity at your own risk. Anyone working with tert-butyl chloroacetate should understand not all grades fit the same purpose. A little time spent on due diligence saves a mountain of trouble down the line. The best labs stay picky, and in chemistry, that’s where safety and innovation both start.
| Names | |
| Preferred IUPAC name | 2-chloro-2-methylpropan-2-yl 2-chloroacetate |
| Other names |
Chloroacetic acid tert-butyl ester
Tert-butyl 2-chloroacetate 2-Chloroacetic acid tert-butyl ester t-Butyl chloroacetate |
| Pronunciation | /ˌtɜːrtˈbjuːtɪl klɔːr.oʊ.əˈsiː.teɪt/ |
| Identifiers | |
| CAS Number | 107-59-5 |
| Beilstein Reference | 1209247 |
| ChEBI | CHEBI:52088 |
| ChEMBL | CHEMBL415280 |
| ChemSpider | 11545 |
| DrugBank | DB14226 |
| ECHA InfoCard | 100.012.289 |
| EC Number | 207-937-4 |
| Gmelin Reference | 8037 |
| KEGG | C14191 |
| MeSH | D017292 |
| PubChem CID | 12417 |
| RTECS number | AF8305000 |
| UNII | X6M9PBG8N8 |
| UN number | UN2657 |
| Properties | |
| Chemical formula | C6H11ClO2 |
| Molar mass | 150.62 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Odor | Pungent |
| Density | 1.049 g/mL at 25 °C |
| Solubility in water | slightly soluble |
| log P | 1.9 |
| Vapor pressure | 0.4 mmHg (20°C) |
| Acidity (pKa) | pKa = 2.60 |
| Basicity (pKb) | pKb = 12.84 |
| Magnetic susceptibility (χ) | -40.5·10⁻⁶ cm³/mol |
| Refractive index (nD) | 1.409 |
| Viscosity | 1.312 cP (25°C) |
| Dipole moment | 2.20 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 345.6 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -499.5 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -688.6 kJ/mol |
| Pharmacology | |
| ATC code | '' |
| Hazards | |
| GHS labelling | GHS02, GHS07 |
| Pictograms | GHS02,GHS07 |
| Signal word | Warning |
| Hazard statements | H302, H315, H319, H335 |
| Precautionary statements | P210, P261, P280, P305+P351+P338, P337+P313, P301+P312, P330, P403+P233 |
| NFPA 704 (fire diamond) | 1-2-0- (OX) |
| Flash point | 72 °C |
| Autoignition temperature | 410 °C |
| Lethal dose or concentration | LD50 (oral, rat): 1600 mg/kg |
| LD50 (median dose) | LD50 (median dose) = 580 mg/kg (rat, oral) |
| NIOSH | DO7125000 |
| PEL (Permissible) | Not established |
| REL (Recommended) | 0.6 mg/m³ |
| Related compounds | |
| Related compounds |
Methyl chloroacetate
Ethyl chloroacetate Isopropyl chloroacetate Benzyl chloroacetate Chloroacetic acid Tert-butyl bromoacetate Tert-butyl acetate |
