Material Safety Data Sheet (MSDS): Tert-Butyl Bromoacetate

Identification

Product Name: Tert-Butyl Bromoacetate
Chemical Formula: C6H11BrO2
CAS Number: 5292-43-3
Synonyms: t-Butyl Bromoacetate, TBA, Tert-butyl 2-bromoacetate
Recommended Uses: Organic synthesis, chemical research, pharmaceutical intermediate
Supplier: Chemical manufacturers, laboratory suppliers
Emergency Contact: Local emergency services and poison control center

Hazard Identification

Hazard Class: Acute Toxicity (Oral, Inhalation, Dermal); Skin Irritation; Eye Damage
GHS Label Elements: Signal Word: Danger
Pictograms: Skull and crossbones, exclamation mark, corrosion
Hazard Statements: Can cause serious eye damage, skin irritation, may be harmful if inhaled or swallowed, toxic to aquatic life
Precautionary Statements: Avoid breathing vapors, use only outdoors or in well-ventilated area, wear protective gloves and eye protection, wash hands thoroughly after handling

Composition / Information on Ingredients

Chemical Name: Tert-Butyl Bromoacetate
Common Name: t-Butyl Bromoacetate
Concentration: ≥98%
Impurities: Trace organic acids & brominated side products (typically less than 1%)
Hazards Associated: Main hazards derived from primary substance and low-level brominated organics

First Aid Measures

Inhalation: Move to fresh air, keep at rest, seek medical advice if respiratory irritation or symptoms develop
Skin Contact: Remove contaminated clothing, wash affected area with plenty of soap and water, seek medical attention for persistent irritation
Eye Contact: Rinse thoroughly with water for at least 15 minutes lifting upper and lower lids, remove contact lenses, seek immediate medical assistance
Ingestion: Do not induce vomiting, rinse mouth with water, call emergency medical service or poison control, do not give anything by mouth if person is unconscious
Most Important Symptoms/Effects: Severe eye irritation, burns, headache, nausea, skin burns, possible respiratory tract irritation

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Unsuitable Media: High-pressure water streams can spread liquid
Specific Hazards: Releases toxic and corrosive fumes (hydrogen bromide, carbon oxides) under fire conditions
Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective gear
Advice for Firefighters: Keep containers cool with water spray, avoid inhaling fumes, evacuate area if necessary
Decomposition Products: Hydrogen bromide, carbon monoxide, carbon dioxide

Accidental Release Measures

Personal Precautions: Evacuate non-essential personnel, wear chemical-resistant gloves, protective clothing, safety goggles, and respirator
Environmental Precautions: Prevent further leakage or spillage, avoid discharge to sewers and waterways
Method for Clean-Up: Absorb spill with inert material (sand, earth, vermiculite), collect in proper chemical waste containers, ventilate area, wash area with plenty of water
Emergency Procedures: Isolate hazard area, restrict access, contain spill, follow company chemical spill protocol

Handling and Storage

Safe Handling: Work in a chemical fume hood, avoid contact with skin, eyes, clothing, and breathing vapors, use only in controlled, ventilated areas, never eat or drink in work area
Storage Conditions: Store in tightly closed container, in a cool, dry, well-ventilated place, keep away from incompatible materials (strong bases, oxidizers) and direct sunlight
Specific Requirements: Use secondary containment, store upright, clearly label containers
Incompatibility: Strong alkalis, reducing agents, and oxidizing substances

Exposure Controls and Personal Protection

Engineering Controls: Use fume hoods, eyewash stations, safety showers, maintain adequate ventilation
Exposure Limits: No specific official occupational exposure limits for Tert-Butyl Bromoacetate; handle as hazardous material
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles or face shield, lab coat, long sleeves, closed footwear, respiratory protection if vapor possible
Hygiene Measures: Wash hands before breaks and after work, remove contaminated clothing promptly

Physical and Chemical Properties

Appearance: Clear to pale yellow liquid
Odor: Mild, sweet
Odor Threshold: Not established
pH: Not applicable (neutral to slightly acidic in water)
Melting Point: -23°C
Boiling Point: 162°C
Flash Point: 63°C (closed cup)
Evaporation Rate: Not available
Flammability: Not readily flammable, combustible liquid
Explosive Limits: Not established
Vapor Pressure: 1.3 mmHg at 25°C
Vapor Density: >1 (air = 1)
Relative Density: 1.31 g/cm³
Solubility: Slightly soluble in water, soluble in organic solvents (ethanol, ether, chloroform)
Partition Coefficient (n-octanol/water): Approximately 2.5
Auto-ignition Temperature: Not available
Decomposition Temperature: Not available
Viscosity: Not available

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts vigorously with strong bases, acids, and oxidizing agents
Conditions to Avoid: Heat, sunlight, open flames, moisture, incompatible materials
Hazardous Decomposition Products: Hydrogen bromide, carbon monoxide, carbon dioxide
Polymerization: Hazardous polymerization will not occur under normal processing

Toxicological Information

Acute Effects: Irritation to eyes, skin, and respiratory tract; central nervous system effects from inhalation
LD50 (Oral, Rat): ~200 mg/kg
Skin Corrosion/Irritation: Causes burns to skin on contact
Serious Eye Damage/Irritation: Causes severe eye irritation, risk of permanent damage
Respiratory Sensitization: Data not available, but vapors may cause coughing, sore throat
Carcinogenicity: No data available, not listed as a carcinogen (IARC, NTP)
Mutagenicity: No reliable studies found
Reproductive Toxicity: No reliable studies found
Other Toxicology: Prolonged or repeated exposure can cause organ damage or sensitization

Ecological Information

Toxicity: Highly toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Not rapidly biodegradable, remains in water and soil
Bioaccumulation: Potential moderate for bioaccumulation in aquatic organisms
Mobility in Soil: Moderate to high, can penetrate soil and contaminate groundwater
Other Adverse Effects: Avoid release to the environment, risk of surface water contamination significant

Disposal Considerations

Waste Treatment Methods: Dispose as hazardous chemical waste using licensed waste disposal contractor
Product Disposal: Incinerate in chemical incinerator equipped with afterburner and scrubber, follow all local, regional, and national regulations
Container Disposal: Rinse thoroughly, dispose as hazardous waste; do not reuse empty containers
Precautions: Never pour into drains or watercourses, must handle as per chemical waste legislation
Special Instructions: Consult environmental authority for correct disposal process

Transport Information

UN Number: 2810
UN Proper Shipping Name: Toxic liquid, organic, n.o.s. (Tert-Butyl Bromoacetate)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Marine pollutant
Special Precautions: Keep tightly sealed in transit, avoid leaks, follow strict documentation and labeling, must be handled by trained handlers only
Transport Regulations: Compliant with ADR, RID, IMDG, ICAO/IATA requirements

Regulatory Information

Workplace Safety: Subject to national health and safety regulations for hazardous and toxic substances
Inventory Listings: Registered under international chemical inventories (TSCA, EINECS, DSL)
Labeling Requirements: Must carry GHS labeling, hazard codes, risk and safety phrases
Other Regulations: OSHA (US), REACH (EU), WHMIS (Canada) regulations apply
Restrictions: For laboratory, industrial, and research use only; not for food, cosmetic, or household uses
Exposure Limits: No specifically assigned permissible exposure limit; default to general exposure controls for hazardous organics