MSDS: Tert-Butyl 2-Bromo Isobutyrate

1. Identification

Product Name: Tert-Butyl 2-Bromo Isobutyrate
Synonyms: 2-Bromo-2-methylpropanoic acid tert-butyl ester
CAS Number: 24002-44-4
Recommended Use: Chemical intermediate, research and development
Supplier Information: Manufacturer details, emergency phone number, address — referenced on site signage
Emergency Contact: Refer to local means of escalation, including fire brigade and poison control

2. Hazard Identification

GHS Classification: Acute toxicity (oral, dermal, inhalation), Skin irritation, Eye irritation, Specific target organ toxicity
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and serious eye irritation, may cause respiratory irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, fumes, mist, or vapor; wash thoroughly after handling; do not eat, drink, or smoke during use; use only outdoors or in a well-ventilated area; wear protective gloves, clothing, eye, and face protection
Other Hazards: May cause cough or breathing difficulties, hazardous in significant or repeated contact, dangerous to aquatic life with long-lasting effects

3. Composition / Information on Ingredients

Chemical Identity: Tert-Butyl 2-Bromo Isobutyrate
Chemical Formula: C7H13BrO2
Concentration: ≥98% (by weight)
Impurities: Possible trace organic residues from synthesis, no known stabilizers
Component Disclosure: No known nonhazardous components exceeding reporting thresholds

4. First Aid Measures

Inhalation: Move to fresh air, keep at rest in a position comfortable for breathing, seek immediate medical attention for symptoms
Skin Contact: Remove contaminated clothing, wash thoroughly with soap and water, contact physician for signs of persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy, seek prompt medical evaluation
Ingestion: Rinse mouth, do not induce vomiting, seek medical advice and provide SDS to responders
Note to Physician: Provide symptomatic and supportive care, monitor respiratory and cardiovascular function, consider gastric lavage for large amounts, ensure chemical remains in original packaging

5. Fire-Fighting Measures

Suitable Extinguishing Media: Use dry chemical, CO2, alcohol-resistant foam, or water spray
Unsuitable Media: Direct water jet (can spread burning liquid)
Hazardous Combustion Products: Hydrogen bromide, carbon monoxide, carbon dioxide, other irritant gases
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective clothing
Fire-Fighting Instructions: Prevent runoff into drains, contain firewater, approach upwind, cool containers with water spray

6. Accidental Release Measures

Personal Precautions: Use personal protective equipment, avoid breathing vapors, ensure ventilation
Environmental Precautions: Prevent entry into drains, water courses, or soil
Methods for Containment and Cleaning Up: Stop all sources of leak if safe, absorb spill with inert materials (sand, earth), collect and place in suitable containers for disposal, provide adequate ventilation, clean contaminated area with water and detergent
Decontamination: Avoid creating dust or vapor

7. Handling and Storage

Safe Handling: Avoid contact with eyes, skin, and clothing, do not breathe dust, vapor, or mist, handle under fume hood when possible, wash hands before breaks and after use, keep away from food and beverages
Conditions for Safe Storage: Store in tightly closed original container, in a cool, dry, well-ventilated place, keep away from incompatible substances (strong oxidizing agents, acids), protect from heat and sunlight, maintain secondary containment for large quantities
Hygiene Practices: Change contaminated clothing and launder before reuse

8. Exposure Controls and Personal Protection

Exposure Limits: No specific occupational exposure limits established; follow general safety guidelines
Engineering Controls: Use with local exhaust ventilation, use laboratory fume hood for small-scale tasks
Personal Protective Equipment: Approved chemical splash goggles, face shield, chemical resistant gloves (nitrile or neoprene), long-sleeved lab coat, rubber or vinyl apron for handling large volumes, closed footwear
Respiratory Protection: Approved respirator for vapor/dust/mist formation
Environmental Controls: Minimize release to environment, dispose of cleaning materials securely

9. Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid
Odor: Characteristic mild ester
Odor Threshold: Not available
pH: Not applicable
Melting Point/Freezing Point: -20°C (approximate)
Boiling Point: 185°C
Flash Point: 66°C (closed cup, estimate)
Evaporation Rate: Not determined
Flammability: Combustible on heating
Explosive Limits: Not determined
Vapor Pressure: 0.2 mmHg at 20°C
Vapor Density: Not determined
Relative Density: 1.24 g/cm³
Solubility: Not miscible in water, soluble in most organic solvents
Partition Coefficient (n-octanol/water): Not available
Auto-Ignition Temperature: Not determined
Decomposition Temperature: Not determined
Viscosity: Not determined

10. Stability and Reactivity

Chemical Stability: Stable under recommended handling and storage conditions
Possibility of Hazardous Reactions: Reacts with strong oxidizers, acids, bases; may form toxic fumes under fire
Conditions to Avoid: Heat, flames, ignition sources, prolonged exposure to air or moisture
Incompatible Materials: Strong oxidizing agents, strong acids, reactive metals
Hazardous Decomposition Products: Hydrogen bromide, carbon oxides, byproducts on thermal decomposition

11. Toxicological Information

Acute Toxicity: Harmful if swallowed or inhaled
Inhalation: May irritate mucous membranes, nose, and throat
Skin Contact: Causes irritation, may be harmful if absorbed
Eye Contact: Causes severe irritation
Ingestion: Gastrointestinal symptoms (nausea, vomiting, diarrhea), risk of chemical burns
Chronic Effects: Prolonged contact can worsen effects, not classified as carcinogenic or mutagenic under current guidelines
Sensitization: No data found for skin or respiratory sensitization
Target Organs: Possibly liver, kidneys, central nervous system (based on chemical family)
Other Data: Detailed toxicology available for related bromo isobutyrates

12. Ecological Information

Ecotoxicity: Toxic to aquatic life, can cause long-term adverse effects in aquatic environments
Persistence and Degradability: Not readily biodegradable, stable to hydrolysis under environmental conditions
Bioaccumulative Potential: May bioaccumulate due to moderate lipophilicity, partition coefficient undetermined
Mobility in Soil: Low solubility, moderate vapor pressure, may partition to sediment or soil organic matter
Other Adverse Effects: Harmful at low concentrations in aquatic ecosystems, do not release to environment uncontrolled

13. Disposal Considerations

Disposal Methods: Incineration in authorized facility, ensure provision for full combustion and elimination of hazardous byproducts
Contaminated Packaging: Rinse containers, destroy by controlled means, do not reuse for other chemicals
Local Regulations: Follow guidance from environmental, hazardous waste, and chemical management authorities
Other Precautions: Manage in accordance with local, national, and regional rules; avoid sewer and surface water discharge

14. Transport Information

UN Number: Not regulated as a dangerous good under international transport laws
UN Shipping Name: Not applicable
Hazard Class: Not classified
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant but handle with environmental precautions
Special Transport Precautions: Ship tightly sealed, upright, and labeled, avoid temperature extremes

15. Regulatory Information

OSHA HazCom Status: Hazardous chemical under US OSHA 29 CFR 1910.1200
TSCA Inventory: Listed or exempted
EU Regulation: REACH (Consult specific registration), CLP classification applies
Canada DSL/NDSL: Check status prior to import/use
WHMIS Classification: Classified as hazardous, reference local SDS portal
Other Regulations: Not subject to international chemical weapons conventions, no known occupational carcinogen status
Labeling Compliance: GHS-aligned pictograms and warnings