Material Safety Data Sheet (MSDS) – Isopropyl 2-Bromo-2-Methylpropanoate

1. Identification

Product Name: Isopropyl 2-Bromo-2-Methylpropanoate
Synonyms: 2-Bromo-2-methylpropanoic acid isopropyl ester
CAS Number: 69129-58-8
Recommended Use: Organic synthesis, chemical research, laboratory use
Manufacturer/Distributor: Information available through Safety Office or chemical supplier
Emergency Contact Number: Refer to local emergency services or poison control center
Address: Manufacturer or distributor address should be provided by supplier invoice or storage log
Email/Website: Support or safety contact as listed by supplier documentation

2. Hazard Identification

Classification: Flammable liquids (Category 3), Acute toxicity (Oral, Category 4), Skin corrosion/irritation (Category 2), Eye damage/irritation (Category 2A)
Pictogram: Flame, Exclamation mark
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor. Harmful if swallowed. Causes skin and eye irritation. Can cause respiratory irritation if inhaled.
Precautionary Statements: Keep away from heat, sparks, open flames. No smoking. Wear protective gloves, eye and face protection. Use only outdoors or in well-ventilated area. Avoid breathing vapors, mist or spray. Wash thoroughly after handling.

3. Composition / Information on Ingredients

Chemical Name: Isopropyl 2-Bromo-2-Methylpropanoate
CAS Number: 69129-58-8
EC Number: 614-000-7
Concentration: > 99% (by weight)
Impurities: Trace organic contaminants including possible residual solvent, check supplier documentation for purity details.

4. First Aid Measures

Inhalation: Remove person to fresh air immediately. Monitor for signs of breathing difficulty. Seek medical advice if symptoms persist.
Skin Contact: Wash affected area generously with soap and water. Remove contaminated clothing. Seek medical attention for irritation or burns.
Eye Contact: Rinse eyes slowly and gently for minimum 15 minutes. Remove contact lenses if present and easy to do. Continue rinsing and call physician.
Ingestion: Rinse mouth thoroughly. Do not induce vomiting without medical direction. Contact poison center or physician right away.
Most Important Symptoms and Effects: Burning sensation, coughing, stinging, redness, dermatitis, gastrointestinal discomfort.
Advice to Physician: Treat symptoms, provide supportive measures as necessary. Consider risk of chemical pneumonitis if aspirated.

5. Fire-Fighting Measures

Suitable Extinguishing Media: Use dry chemical, CO2, alcohol-resistant foam, or water spray in a fine mist.
Unsuitable Extinguishing Media: Do not use water jet, may spread liquid fire.
Specific Hazards Arising from the Chemical: Produces toxic, corrosive fumes including hydrogen bromide and carbon oxides when burned.
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear.
Advice: Remove containers from fire area if safe. Cool containers with water spray. Prevent fire-fighting runoff from entering water systems or drains.

6. Accidental Release Measures

Personal Precautions: Evacuate area. Wear chemical-resistant gloves, eye protection, and suitable respirator if vapors form.
Environmental Precautions: Prevent further leakage or spillage; do not allow material to enter drains or waterways.
Methods for Containment and Clean Up: Absorb with inert material (sand, earth, vermiculite), transfer to suitable closed chemical waste container. Clean area fully using detergent and water, ensuring full decontamination. Dispose as hazardous waste, observing all local requirements.

7. Handling and Storage

Handling: Handle in well-ventilated area or fume hood. Wear gloves, goggles, lab coat. Avoid inhalation, ingestion, and contact with skin/eyes. Wash hands thoroughly before breaks and after handling.
Storage: Store tightly closed in a cool, dry, well-ventilated space. Keep away from heat, sparks, direct sunlight, and incompatible materials (strong oxidizers, bases). Store away from sources of ignition. Keep container tightly sealed and upright.

8. Exposure Controls and Personal Protection

Exposure Limits: No OSHA or ACGIH occupational exposure limits established. Always minimize exposure.
Engineering Controls: Use with adequate local exhaust or fume hood. Eye wash stations and emergency showers should be nearby.
Personal Protection: Safety goggles, chemical-resistant gloves (nitrile or neoprene recommended), lab coat or apron.
Respiratory Protection: Respirator with organic vapor cartridge if ventilation is insufficient.
Hygiene Measures: Do not eat, drink, or smoke during use. Wash hands after handling or removing protective gear.

9. Physical and Chemical Properties

Appearance: Clear, colorless liquid
Odor: Characteristic ester-like smell
Odor Threshold: Not determined
pH: Not applicable (nonaqueous liquid)
Melting Point/Freezing Point: Below 0°C (32°F), precise value absent
Boiling Point: 174–180°C (345–356°F), at atmospheric pressure
Flash Point: Approximately 65°C (149°F), closed cup
Evaporation Rate: Not determined
Flammability: Liquid, combustible, not explosive under normal conditions
Upper/Lower Flammability or Explosive Limits: Not established
Vapor Pressure: Estimated 1.2 mmHg at 25°C
Vapor Density: Greater than 1 (air = 1)
Relative Density: 1.20–1.25 g/mL at 20°C
Solubility: Practically insoluble in water, soluble in organic solvents (acetone, ethanol)
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: Data not available
Decomposition Temperature: May decompose above 180°C
Viscosity: Data not available

10. Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Not highly reactive under normal working conditions
Possibility of Hazardous Reactions: Reacts with strong oxidizers, acids, and bases
Conditions to Avoid: Heat, flames, sparks, incompatible chemicals, prolonged or repetitive exposure to air or moisture
Incompatible Materials: Strong acids, bases, oxidizers, reducing agents, amines, and strong alkalis
Hazardous Decomposition Products: Hydrogen bromide, carbon oxides, possible alkyl bromides

11. Toxicological Information

Possible Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Data limited; estimated LD50 (Oral, rat) 500–2000 mg/kg
Skin Corrosion/Irritation: Causes irritation, may induce redness, inflammation
Serious Eye Damage/Irritation: Causes moderate to severe eye irritation
Respiratory or Skin Sensitization: Not classified as a sensitizer, but prolonged exposure may trigger symptoms
Chronic Effects: Prolonged or repeated exposure may cause dermatitis, liver, or kidney effects. Data insufficient for full hazard assessment.
Symptoms of Overexposure: Dizziness, headache, nausea, skin redness, coughing
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Mutagenicity: Not enough data
Reproductive Toxicity: Not enough data
Other Relevant Data: No information found for specific long-term effects in humans

12. Ecological Information

Ecotoxicity: Toxic to aquatic life at significant concentrations. May bioaccumulate in aquatic organisms.
Persistence and Degradability: Limited biodegradability under environmental conditions
Bioaccumulative Potential: Moderate, caution advised for environmental contamination
Mobility in Soil: Low water solubility reduces mobility; likely to partition to organic matter
Other Adverse Effects: Precaution required, avoid uncontrolled release. No data for long-term environmental impact, recommend full containment.

13. Disposal Considerations

Waste Treatment Methods: Dispose of in compliance with all local, regional, national, and international regulations. Rinse and triple clean containers before disposal.
Disposal of Product: Do not discharge to drains, surface water, or ground. Hand to licensed, responsible chemical waste processor.
Disposal of Packaging: Treat emptied packaging as hazardous unless fully cleaned. Recycle or incinerate through qualified company where allowed.
Special Precautions: Identify and label waste clearly. Notify responsible regulatory authority if major environmental release occurs.

14. Transport Information

UN Number: UN 1993
UN Proper Shipping Name: Flammable liquid, n.o.s. (contains Isopropyl 2-Bromo-2-Methylpropanoate)
Transport Hazard Class: 3 (flammable liquid)
Packing Group: III
Environmental Hazards: Dangerous to aquatic organisms, avoid release during transport
Special Precautions for User: Use UN-approved packaging. Avoid temperature extremes. Inform handlers of hazardous nature.
Transport Regulations: Adhere to ADR/RID/IMDG/IATA for road, sea, and air transport. Notify carriers if aggregate shipping exceeds permitted limits.

15. Regulatory Information

TSCA Inventory: Listed or meets reporting criteria for research chemicals
REACH Registration: Supplier/importer to confirm status
Other Inventories: Check local/national chemical inventories (DSL, EINECS, etc.)
SARA Title III: Not subject to SARA Section 302, 304, 313 reporting
CERCLA Reportable Quantity: Not assigned
California Prop 65: Not identified as listed compound
Other Regulations: Handle and store per country- or industry-specific guideline, including OSHA or European CLP rules
Labeling Requirements: Flammable Liquid, Irritant, Harmful