Material Safety Data Sheet (MSDS) - Ethyl Bromoacetate

Identification

Product Name: Ethyl Bromoacetate
Chemical Formula: C4H7BrO2
CAS Number: 105-36-2
Molecular Weight: 167.00 g/mol
Synonyms: Bromoacetic acid ethyl ester, Ethyl 2-bromoacetate
Recommended Uses: Laboratory reagent, organic synthesis, pharmaceutical intermediate
Supplier: Major chemical companies and research suppliers worldwide
Contact Information: Emergency contact numbers provided on product labels by individual suppliers

Hazard Identification

GHS Classification: Acute Toxicity (Oral) Category 3, Skin Corrosion/Irritation Category 2, Eye Damage/Irritation Category 2, Acute Inhalation Toxicity Category 3
Signal Word: Danger
Hazard Statements: Toxic if swallowed, toxic if inhaled, causes skin irritation, causes serious eye irritation
Pictograms: Skull and crossbones, exclamation mark, corrosion
Precautionary Statements: Do not breathe dust, fume, gas, mist, vapors, or spray; wash skin thoroughly after handling; use only outdoors or in a well-ventilated area; wear protective gloves, clothing, and eye/face protection; store locked up

Composition / Information on Ingredients

Chemical Name: Ethyl Bromoacetate
Percentage: More than 98% (product purity varies by manufacturer)
Impurities: Trace levels of bromoacetic acid, less than 2%, no significant effect on hazard classification
Chemical Family: Haloacetates
Product Code: Varies by supplier

First Aid Measures

Inhalation: Move victim to fresh air; keep person at rest in position comfortable for breathing; seek immediate medical attention if symptoms persist
Skin Contact: Remove contaminated clothing immediately; rinse skin with plenty of water for at least 15 minutes; get medical help if irritation persists
Eye Contact: Rinse cautiously with water for at least 15 minutes; remove contact lenses if present and easy to do; continue rinsing and get prompt medical attention
Ingestion: Rinse mouth; do not induce vomiting; get medical attention right away; never give anything by mouth to an unconscious person
Note to Physician: Treat symptomatically; respiratory, gastrointestinal, and dermal irritation possible

Fire-Fighting Measures

Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam; water may be ineffective unless used to cool containers
Hazards from Combustion: Emits toxic fumes of hydrogen bromide, carbon monoxide, carbon dioxide under fire conditions
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Fire/Explosion Risk: Flammable; use water spray to cool unopened containers exposed to fire; avoid inhaling combustion gases
Advice for Responders: Approach fire from upwind to avoid hazardous vapors and decomposition products

Accidental Release Measures

Personal Precautions: Evacuate area; ensure adequate ventilation; wear appropriate personal protective equipment including gloves, protective clothing, and eye protection
Environmental Precautions: Prevent leakage or spillage into drains, surface waters, and soil; notify authorities if large spills occur
Methods for Clean-Up: Absorb spill with inert absorbent material like sand or earth; collect in a container for disposal; clean contaminated surfaces thoroughly with water and detergent
Preventive Measures: Remove all sources of ignition; ventilate area immediately; avoid breathing vapors and contact with skin or eyes

Handling and Storage

Handling: Avoid breathing vapors, mist, or spray; use only in ventilated areas; do not get in eyes, on skin, or clothing; wash hands thoroughly after handling; keep container tightly closed
Storage: Store in a cool, well-ventilated place away from heat sources and direct sunlight; keep containers tightly sealed; store locked up, away from incompatible materials such as strong oxidizing agents, bases, and amines
General Hygiene: Keep away from food, drink, and animal feed; avoid contamination of personal clothing

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established ACGIH or OSHA exposure limits; minimize exposure using engineering controls
Engineering Controls: Use fume hoods or local exhaust ventilation to reduce airborne concentration
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), splash goggles or face shield, lab coat or protective suit, and suitable respiratory protection if ventilation is not adequate
Hygiene Measures: Wash thoroughly after handling; remove contaminated clothing before leaving work area; do not eat, drink, or smoke during use

Physical and Chemical Properties

Appearance: Clear, colorless to pale yellow liquid
Odor: Strong, penetrating, fruity odor
Boiling Point: 159-161°C (318-322°F)
Melting Point: -51°C
Flash Point: 66°C (151°F) closed cup
Vapor Pressure: Approximately 2.1 mmHg at 20°C
Solubility: Slightly soluble in water; soluble in organic solvents like alcohols, ethers, and chloroform
Specific Gravity: 1.54 at 20°C
pH: Not applicable (neutral organic liquid)
Partition Coefficient (Log Kow): Estimated around 1.2-1.6
Auto-ignition Temperature: Not established
Evaporation Rate: Moderate compared to water
Vapor Density: 5.8 (air = 1)

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions; decomposes in light and under prolonged exposure to moisture
Reactivity: Reacts with strong bases, strong oxidizers, and amines
Hazardous Reactions: May react violently with sodium, potassium, or strong reducing agents
Decomposition Products: Toxic gases such as hydrogen bromide, carbon oxides
Incompatible Materials: Strong acids, strong bases, strong oxidizing agents, and some metals

Toxicological Information

Acute Toxicity: Harmful or fatal if swallowed, inhaled, or absorbed through the skin; LD50 (oral, rat): 350 mg/kg; LD50 (dermal, rabbit): 660 mg/kg
Skin Corrosion/Irritation: Causes moderate to severe skin irritation
Eye Damage/Irritation: Causes irritation with potential for serious damage
Respiratory Sensitization: May cause coughing, shortness of breath, and other respiratory symptoms
Chronic Effects: Long-term exposure may cause damage to the liver, kidneys, and nervous system
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, or OSHA
Mutagenicity: There is a potential for mutagenic effects, though no conclusive studies available
Reproductive Toxicity: Evidence lacking, but related compounds raise concern for reproductive health

Ecological Information

Toxicity to Aquatic Organisms: Toxic to aquatic life with long lasting effects; LC50 (fish): 14 mg/L (96h, fathead minnow)
Environmental Fate: Can persist in the environment; does not easily undergo biodegradation in water or soil
Bioaccumulation: Low to moderate potential based on partition coefficient
Mobility: Moderately mobile in soil and water; may contaminate groundwater
Additional Info: Prevent release into drains, water courses, and soil to avoid harm to aquatic organisms and ecosystems

Disposal Considerations

Waste Disposal Methods: Dispose of contents/container according to local, regional, national, and international regulations; use certified chemical waste disposal contractors
Incineration: Suitable for hazardous waste incinerators equipped with afterburner and scrubber systems
Contaminated Packaging: Triple rinse containers and puncture before disposal; send to permitted waste facility
Precautions: Do not release into the environment; do not dispose via sewage system; avoid landfill unless authorized

Transport Information

UN Number: UN 1891
Proper Shipping Name: Ethyl bromoacetate
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Hazard Label: Toxic; additional environmental hazard label in some regions
Special Precautions: Transport only in tightly sealed containers; keep away from foodstuffs, animal feed, and incompatible materials during transit
Regulatory Guidelines: Subject to the International Maritime Dangerous Goods (IMDG) Code, International Air Transport Association (IATA) regulations, and U.S. Department of Transportation (DOT) requirements

Regulatory Information

U.S. Regulations: Listed in the Toxic Substances Control Act (TSCA) inventory; subject to reporting under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) with a reportable quantity of 100 pounds; regulated as hazardous under the Resource Conservation and Recovery Act (RCRA)
European Union (CLP/GHS): Classification includes acute toxicity, skin and eye irritation; subject to REACH registration and restrictions
Canadian WHMIS: Class D2B (Toxic Material Causing Other Toxic Effects)
Labeling Requirements: Warning labels include hazard pictograms, risk phrases, safety advice, manufacturer contact info, and batch numbers
International Inventories: Present on Japan ENCS, Korea ECL, Australia AICS, China IECSC, New Zealand NZIoC
Additional Info: Always consult relevant local, regional, and national regulations for further requirements and up-to-date guidance