Material Safety Data Sheet for Ethyl 2-Bromopropionate

Identification

Product Name: Ethyl 2-Bromopropionate
Chemical Formula: C5H9BrO2
CAS Number: 535-11-5
Synonyms: Propanoic acid, 2-bromo-, ethyl ester; Ethyl 2-bromopropanoate
Uses: Intermediate in organic synthesis, pharmaceutical manufacturing, laboratory reagent
Manufacturer/Supplier: Information available on request
Contact Phone Number: Emergency and non-emergency contact details must be clearly visible on packaging
Recommended Use: Research, industrial synthesis only; avoid consumer or food use

Hazard Identification

GHS Classification: Skin irritation, Serious eye irritation, Respiratory irritation, Potentially toxic if swallowed or inhaled
Signal Word: Warning
Hazard Pictograms: GHS07 (Exclamation mark)
Hazard Statements: Causes skin irritation, causes serious eye damage, may cause respiratory tract irritation, harmful if swallowed
Precautionary Statements: Wear protective gloves and eye protection; avoid breathing vapors or mist; wash hands thoroughly after handling; do not eat, drink, or smoke during use
Potential Health Effects: Short exposure may trigger skin redness, rash, or burning sensation; inhalation can cause coughing, throat irritation, dizziness, headaches; eye exposure produces severe irritation or possible damage; ingestion might result in nausea, abdominal pain

Composition / Information on Ingredients

Chemical Name: Ethyl 2-Bromopropionate
CAS Number: 535-11-5
Purity: ≥ 98% by weight
Impurities: Trace levels of related esters, halides, or unreacted starting materials, commonly below regulatory thresholds
Additives: None intentionally added

First Aid Measures

Inhalation: Remove to fresh air immediately; keep at rest; seek medical attention if symptoms persist—such as coughing or shortness of breath
Skin Contact: Wash exposed area thoroughly with soap and water; remove contaminated clothing; seek medical assistance for persistent irritation or blistering
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if easy to do so; continue rinsing; seek urgent medical care due to potential for severe irritation
Ingestion: Rinse mouth, do not induce vomiting; call a poison control center or doctor right away; provide product label or MSDS for reference during medical care
Most Important Symptoms and Effects: Skin redness, burns, severe eye irritation, nausea, cough, confusion

Fire-Fighting Measures

Suitable Extinguishing Media: Carbon dioxide, dry chemical, foam; avoid using water jets which may spread liquid or increase hazard
Specific Hazards: Vapors may form explosive mixtures with air; combustion can produce carbon monoxide, carbon dioxide, hydrogen bromide, and possibly corrosive vapors
Special Protective Equipment: Full-face self-contained breathing apparatus, chemical-resistant firefighting clothing
Other Precautions: Move containers from fire area if possible; use water spray to cool fire-exposed containers; keep runoff water contained—do not allow it to reach sewers or waterways

Accidental Release Measures

Personal Precautions: Leave area and ventilate space; use appropriate chemical-resistant gloves, goggles, and protective clothing; do not breathe mist or vapor
Environmental Precautions: Prevent further leakage or spillage if safe; avoid contamination of soil, drains, or waterways
Methods for Cleanup: Absorb available liquid with sand, earth, or inert absorbent; collect residue in sealed, labeled containers; decontaminate area with soapy water; dispose of waste according to local, state, or national legislation
Reference for Emergency Responders: Use appropriate containment and collection procedures for hazardous material

Handling and Storage

Handling: Handle only in well-ventilated areas; avoid all contact with skin and eyes; do not breathe vapor; keep away from heat or open flames; secure container cap tightly after each use
Storage: Store in tightly closed original container at ambient temperature, protected from direct sunlight; keep separate from oxidizers, strong bases, or sources of ignition; store in a chemical fume hood for small volumes
Incompatible Materials: Strong oxidizing agents, acids, bases, amines and other nucleophiles
Safe Packaging Materials: Use containers made from compatible plastics or glass; avoid metals prone to corrosion by halogenated compounds
Storage Life: Stability maintained two years under recommended storage conditions

Exposure Controls and Personal Protection

Occupational Exposure Limits: No OSHA PEL or ACGIH TLV specifically established; minimize exposure as a precaution
Engineering Controls: Use chemical fume hood; maintain effective ventilation in all work areas; consider explosion-proof equipment where vapor levels may approach flammability limits
Personal Protective Equipment: Chemical splash goggles, butyl rubber or nitrile gloves, lab coat or apron, suitable footwear
Respiratory Protection: Approved respirator (such as NIOSH) where vapor/mist is generated above safe limits or in poorly ventilated settings
Hygienic Work Practices: Thorough hand washing after handling; remove contaminated clothing promptly; no eating, drinking, or smoking near work area

Physical and Chemical Properties

Appearance: Clear, colorless to faint yellow liquid
Odor: Fruity, ester-like odor
Melting Point: Approximately -43 °C
Boiling Point: 148–150 °C
Flash Point: 55 °C (open cup)
Autoignition Temperature: Data not widely available
Explosion Limits: Vapors may form explosive mixtures—exact limits unspecified
Vapor Pressure: About 3 mmHg at 25 °C
Solubility in Water: Slightly soluble; miscible with most organic solvents
Density: 1.401 g/cm³ at 20 °C
pH: Not applicable
Partition Coefficient (log Kow): Estimated 1.7, indicating moderate potential for bioaccumulation

Stability and Reactivity

Chemical Stability: Remains stable in standard storage conditions; avoid extremes of temperature, moisture, and light
Reactive With: Strong bases, oxidizing agents, amines, reducing agents
Conditions to Avoid: Exposure to elevated temperatures, open flames, electrostatic discharge, and incompatible substances
Hazardous Decomposition Products: Hydrogen bromide, carbon oxides, various low molecular weight organic compounds under fire conditions
Polymerization: No known hazardous polymerization expected

Toxicological Information

Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Moderate when inhaled or ingested; exposure may cause coughing, dizziness, vomiting, skin redness, or severe eye irritation
Chronic Effects: Prolonged or repeated exposure can result in dermatitis, sensitization, or other allergic reactions; no reliable data on carcinogenicity
LD50 Values: Estimated rat oral LD50: 670 mg/kg
Sensitization: May cause allergic skin reactions in sensitive individuals
Reproductive Toxicity: No data available, but prudent avoidance of exposure is warranted
Medical Conditions Aggravated by Exposure: Asthma, eczema, allergies, preexisting skin or airway disorders

Ecological Information

Ecotoxicity: Harmful to aquatic organisms with potential lasting effects in the aquatic environment
Persistence and Degradability: General tendency toward environmental persistence; partial biodegradability under certain conditions
Bioaccumulative Potential: Moderate log Kow value suggests likelihood of some bioaccumulation
Mobility in Soil: Intermediate mobility; may leach to groundwater if spillage occurs on permeable surfaces
Other Adverse Effects: Contamination of water systems can disrupt aquatic life; release into sewers or public waterways must be prevented

Disposal Considerations

Waste Treatment Methods: Incinerate at an approved chemical waste facility equipped for halogenated organics
Contaminated Packaging: Dispose of as hazardous waste according to local, state, and national guidelines; do not reuse empty containers
Sewage Disposal: Avoid discharge to sewage systems; reporting required for any accidental discharge
Waste Codes: F-listed waste for spent solvents and non-specific halogenated organics (U-list for unused chemicals)

Transport Information

UN Number: UN 3265
Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (Ethyl 2-Bromopropionate)
Hazard Class: 8 (Corrosive)
Packing Group: III
Label Required: Corrosive label
Transport by Air (IATA): Regulated as dangerous goods; refer to specific airline and IATA documentation
Transport by Sea (IMDG): Marine pollutant code: Yes; follow IMDG guidance
Special Precautions: Keep away from foodstuffs and feed; ensure packaging remains sealed and supported to prevent breakage or leakage during transit

Regulatory Information

TSCA: Listed on the United States Toxic Substances Control Act Inventory
EINECS/ELINCS: Listed in the European Chemical Inventory
SARA Title III (Sections 302/304/313): Not subject to these specific regulations
California Proposition 65: Not listed
WHMIS Classification (Canada): D2B (Toxic material causing other toxic effects)
REACH Status: Pre-registered under European guidelines; official registration for limited use applies
Other International Standards: Complies with labeling and substance reporting requirements in several global jurisdictions; check with local authorities for unique country-specific obligations