MSDS for Ethyl-2-Bromo Butyrate

Identification

Product Name: Ethyl-2-Bromo Butyrate
Chemical Formula: C6H11BrO2
Other Names: Ethyl 2-Bromobutyrate
CAS Number: 600-00-0
Recommended Use: Organic synthesis, intermediates, pharmaceutical manufacturing
Supplier Contacts: Refer to product packaging or purchasing documentation for emergency phone and company address details
Synonyms: 2-bromobutyric acid ethyl ester

Hazard Identification

GHS Classification: Acute toxicity (oral, dermal); Skin and eye irritant; Possible respiratory irritant
Signal Word: Warning
Hazard Pictograms: Skull and crossbones, exclamation mark
Hazard Statements: Harmful if swallowed or in contact with skin; Causes skin and serious eye irritation; May cause respiratory irritation
Precautionary Statements: Avoid breathing vapors; Wash thoroughly after handling; Wear protective gloves, clothing, and eye/face protection
Potential Health Effects: Inhalation causes throat and lung irritation; ingestion harms digestive tract; contact leads to redness, possibly burns; repeated exposure can raise risks for organ damage

Composition / Information on Ingredients

Chemical Name: Ethyl-2-Bromo Butyrate
CAS: 600-00-0
Concentration: ≥ 98% by weight
Impurities: Not significant for hazardous classification
Additives: None

First Aid Measures

Inhalation: Move to fresh air immediately; keep victim warm and at rest; give oxygen if breathing is difficult; seek medical advice if symptoms persist
Skin Contact: Remove contaminated clothing; rinse exposed area thoroughly with water for at least 15 minutes; do not apply ointments; seek medical attention for irritation or burns
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing and get prompt medical help
Ingestion: Rinse mouth out thoroughly; do not induce vomiting unless directed by medical personnel; offer water if victim is conscious; seek medical attention right away

Fire-Fighting Measures

Suitable Extinguishers: Dry chemical, foam, carbon dioxide; avoid water jets, as product may float and spread
Hazardous Combustion Products: Hydrogen bromide fumes, carbon oxides, possible acrid smoke
Advice for Firefighters: Wear self-contained breathing apparatus and full protective clothing; cool containers with water spray if exposed to flames; approach from upwind
Special Fire Hazards: Vapors may form explosive mixtures with air; containers may rupture from pressure build-up

Accidental Release Measures

Personal Precautions: Evacuate area if necessary; wear chemical-resistant gloves, goggles, and appropriate respiratory protection; ventilate area
Environmental Precautions: Prevent runoff into drains, soil, and surface waters; dike and contain spillage
Cleanup Methods: Absorb spills with sand, earth, or inert material; collect into containers for proper disposal; clean residue with water and detergent; ventilate area after cleanup
Decontamination: Use non-sparking tools, avoid flammable materials

Handling and Storage

Safe Handling: Keep containers tightly closed; use only in well-ventilated spaces with chemical fume hood if possible; avoid inhalation and direct contact; do not eat, drink, or smoke during handling; wash hands thoroughly after use
Storage Conditions: Store in cool, dry, well-ventilated areas away from direct sunlight, strong oxidizers, and acids; keep container upright and leak-proof
Incompatible Materials: Strong bases, strong acids, oxidizing agents
Packaging: Use corrosion-resistant containers; secondary containment advised for bulk storage
Specific Uses: Synthesis in controlled environments only

Exposure Controls and Personal Protection

Occupational Exposure Limits: No official OELs established; control exposure as low as possible
Engineering Controls: Work in fume hood; use mechanical exhaust where possible; maintain eye wash and safety shower stations in proximity
Respiratory Protection: Chemical cartridge respirator suitable for organic vapors if exposure risk is present, otherwise supply fresh air
Eye Protection: Chemical splash goggles or full face shield
Skin Protection: Chemical-resistant gloves (nitrile or butyl); impermeable apron or suit; closed-toe shoes
Work Hygiene: Wash thoroughly after handling; remove contaminated clothing and launder before reuse

Physical and Chemical Properties

Appearance: Clear to slightly yellow liquid
Odor: Sharp, pungent, ester-like smell
Odor Threshold: Not established
pH: Not determined (not water soluble)
Boiling Point: 180 – 182°C
Melting Point: Not available
Flash Point: 75°C (closed cup, approximate)
Autoignition Temperature: Not determined
Vapor Pressure: Low at room temperature
Solubility: Immiscible in water, miscible with organic solvents
Specific Gravity: Approximately 1.39 at 20°C
Partition Coefficient (log Kow): Not available
Evaporation Rate: Not available
Viscosity: Not available

Stability and Reactivity

Chemical Stability: Stable under recommended storage; decomposes above 200°C with toxic fumes
Reactivity: Strong alkali and strong oxidants cause rapid reaction
Conditions to Avoid: Heat, sunlight, open flames, moisture ingress
Incompatible Materials: Powdered metals, strong bases, strong acids, oxidizers
Hazardous Decomposition Products: Hydrogen bromide, carbon monoxide, carbon dioxide

Toxicological Information

Acute Toxicity Oral (rats): Reported LD50 ranges from 200–500 mg/kg
Dermal Toxicity: Harmful in contact; may cause irritation, dermatitis
Inhalation Toxicity: Not fully studied; likely to cause mucous membrane and lung irritation
Skin/Eye Irritation: Irritant risk; may cause persistent pain and redness in eyes
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, OSHA
Mutagenicity: No significant data
Sensitization: No available data
Chronic Exposure: Repeated skin or inhalation exposure may increase risk of long-term effects such as dermatitis or respiratory discomfort

Ecological Information

Ecotoxicity: Toxic to aquatic life with long-lasting effects based on chemical structure; laboratory studies lacking
Persistence and Degradability: Expected to be poorly biodegradable in natural waters; halogenated compounds show environmental persistence
Bioaccumulation: May accumulate in aquatic organisms due to moderate hydrophobicity
Mobility in Soil: Low to moderate; can leach through sandy soils
Other Adverse Effects: No data on effects on ozone, climate change

Disposal Considerations

Waste Treatment Methods: Incinerate in approved chemical waste facility; avoid landfill; do not pour down drain
Contaminated Packaging: Dispose containers as hazardous chemical waste; triple rinse and puncture before disposal if possible
Disposal Precautions: Follow all local, regional, and national regulations for hazardous waste
Special Considerations: Neutralize residues under supervision of a specialist before landfill or incineration if permitted locally

Transport Information

UN Number: 2810
Proper Shipping Name: Toxic liquid, organic, n.o.s. (Ethyl-2-Bromo Butyrate)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Hazard Labels: Toxic
Environmental Hazards: Marine pollutant
Special Transport Precautions: Keep separate from food and feedstuffs; transport in tightly closed containers; follow carrier-specific regulations

Regulatory Information

TSCA Inventory: Listed
EINECS Number: 209-937-1
SARA Title III: Not specifically listed for reportable quantities
OSHA Hazardous Chemical: Classified hazardous
Other International Regulations: Subject to chemical regulations in Europe, Japan, Australia, and Canada; consult local resources for country-specific restrictions
Labeling Requirements: GHS label with pictograms, relevant hazard and precaution statements
REACH Status: Registration may be required for imports into EU above one tonne per year
Other Notes: Employer must display safety information in workplace where used or handled