Material Safety Data Sheet for Bromobenzene

1. Identification

Product Name: Bromobenzene
Chemical Formula: C6H5Br
CAS Number: 108-86-1
Synonyms: Phenyl bromide, Monobromobenzene
Recommended Uses: Laboratory reagent, organic synthesis, solvent
Manufacturer/Supplier: Refer to supplier-specific contact information
Emergency Contact: Chemtrec: +1-800-424-9300

2. Hazard Identification

GHS Classification: Acute Toxicity (Oral, Inhalation, Dermal) Category 4, Skin Irritation Category 2, Eye Irritation Category 2A, Specific Target Organ Toxicity Single Exposure Category 3
Pictograms: Exclamation mark, Health hazard
Signal Word: Warning
Hazard Statements: Harmful if swallowed, Inhaled, or in contact with skin; Causes skin and eye irritation; May cause respiratory irritation
Precautionary Statements: Avoid breathing vapors; Wash thoroughly after handling; Wear protective gloves, clothing, and eye protection.

3. Composition / Information on Ingredients

Chemical Name: Bromobenzene
CAS Number: 108-86-1
Concentration: ≥99%
Impurities: Trace impurities, not relevant under normal handling conditions
Additives: No stabilizing additives commonly used.

4. First Aid Measures

General Advice: Move exposed person to a safe area and keep at rest.
Inhalation: Remove person to fresh air, keep comfortable for breathing, seek medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing immediately, rinse skin with plenty of water, use soap if available. Get medical attention if irritation develops.
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if easy to do. Get medical attention.
Ingestion: Do not induce vomiting. Rinse mouth with water. Get medical attention immediately.
Most Important Symptoms: Respiratory irritation, headache, dizziness, skin irritation, eye redness, gastrointestinal discomfort.

5. Fire-Fighting Measures

Suitable Extinguishing Media: Use dry chemical, carbon dioxide (CO₂), foam, or water spray.
Unsuitable Extinguishing Media: Avoid high pressure water jet.
Specific Hazards: Emits toxic fumes of bromine and hydrogen bromide when heated or involved in fire.
Protective Equipment for Firefighters: Full protective clothing with self-contained breathing apparatus.
Special Procedures: Use water spray to cool fire-exposed containers, approach fire from upwind to avoid hazardous vapors.

6. Accidental Release Measures

Personal Precautions: Evacuate unnecessary personnel, ventilate area, use personal protective equipment including gloves, safety goggles, and respirators.
Environmental Precautions: Prevent entry into waterways, sewers, and soil. Alert authorities if spill has entered environment.
Methods for Cleaning Up: Absorb with inert material (sand, earth, vermiculite), place in suitable container for disposal. Clean spill area thoroughly.
Prevention of Secondary Hazards: Eliminate all ignition sources, avoid static discharge, ensure good ventilation.

7. Handling and Storage

Precautions for Safe Handling: Avoid ingestion, inhalation, and contact with skin, eyes, and clothing. Use only in well-ventilated areas. Do not eat or drink in working area. Have emergency equipment readily available.
Conditions for Safe Storage: Store in tightly closed containers, away from light, heat, and sources of ignition. Separate from acids, oxidizing agents. Keep in cool, dry, well-ventilated place.
Incompatible Materials: Oxidizing agents, strong bases, alkali metals.
Packaging Materials: Use containers approved for aromatic hydrocarbons; glass or specific HDPE drums.

8. Exposure Controls and Personal Protection

Exposure Limits: OSHA PEL: Not established; ACGIH TLV: Not established; Company recommended limit: 1 ppm (TWA, guidance only).
Engineering Controls: Use fume hood, explosion-proof exhaust ventilation.
Personal Protective Equipment:
Eye Protection: Chemical safety goggles or face shield.
Hand Protection: Impervious gloves (nitrile, neoprene).
Skin and Body Protection: Lab coat, flame-retardant clothing.
Respiratory Protection: Organic vapor respirator if ventilation insufficient.
Hygiene Measures: Wash hands after handling. Remove contaminated clothing and equipment before entering eating areas.

9. Physical and Chemical Properties

Appearance: Clear, colorless to pale yellow liquid
Odor: Aromatic
Odor Threshold: Not available
pH: Not applicable (neutral organic compound)
Melting Point: -30°C
Boiling Point: 156°C
Flash Point: 48°C (closed cup)
Evaporation Rate: Not available
Flammability: Flammable liquid
Vapor Pressure: 3 mmHg at 25°C
Vapor Density: 5.5 (air = 1)
Density: 1.495 g/cm³
Solubility: Slightly soluble in water, soluble in organic solvents
Partition Coefficient (n-octanol/water): 3.1
Auto-ignition Temperature: 566°C
Decomposition Temperature: Not specified
Viscosity: Not determined

10. Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions.
Possibility of Hazardous Reactions: Forms toxic fumes upon decomposition.
Conditions to Avoid: Heat, flames, sparks, static discharge, direct sunlight.
Incompatible Materials: Strong oxidizers, alkali metals, aluminum.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, hydrogen bromide, bromine vapors.

11. Toxicological Information

Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Oral LD50 (rat): 3160 mg/kg; Inhalation LC50 (rat, 4h): 10.5 mg/L
Skin Corrosion/Irritation: Causes moderate skin irritation
Serious Eye Damage/Irritation: Causes eye irritation
Respiratory or Skin Sensitization: Not classified as a sensitizer
Germ Cell Mutagenicity: Data insufficient
Carcinogenicity: Not listed by IARC, NTP, OSHA
Reproductive Toxicity: No confirmed risk based on animal data
Specific Target Organ Toxicity (STOT): May cause respiratory tract irritation
Symptoms Related to Physical, Chemical, and Toxicological Characteristics: Cough, sore throat, headache, dizziness, nausea, skin redness
Delayed and Immediate Effects: Prolonged or repeated exposure may cause central nervous system effects.

12. Ecological Information

Ecotoxicity: Harmful to aquatic organisms, may cause long-term adverse effects in aquatic environment
Aquatic Toxicity: LC50 (Fish, 96h): 15.7 mg/L (Pimephales promelas); EC50 (Daphnia magna, 48h): 6.8 mg/L
Persistence and Degradability: Partial biodegradation in soil and water; moderately persistent
Bioaccumulative Potential: Potential for bioaccumulation in aquatic species (log Kow 3.1)
Mobility in Soil: Low to moderate, may volatilize from surface water
Other Adverse Effects: Not classified as ozone depleting, not expected to cause endocrine disruption.

13. Disposal Considerations

Disposal Methods: Dispose of contents/container as hazardous chemical waste in accordance with local, regional, national, and international laws.
Contaminated Packaging: Treat as hazardous waste, do not reuse empty containers.
Precautions for Disposal: Never discharge product into water courses or open environment. Use licensed chemical disposal contractor.
Waste Code: US EPA RCRA U225 (hazardous waste, ignitable).

14. Transport Information

UN Number: UN 2514
UN Proper Shipping Name: Bromobenzene
Transport Hazard Class: 3 (Flammable Liquid)
Packing Group: III
Environmental Hazards: Yes
Special Precautions: Keep containers upright, secure properly during transport, avoid heat sources.
Transport Labels: Flammable Liquid Label (red diamond)
Regulatory References: Compliant with ICAO/IATA (air), IMDG (sea), ADR/RID (land).

15. Regulatory Information

OSHA Hazard Communication: Classified as hazardous per 29 CFR 1910.1200
TSCA Inventory: Listed
SARA 313: Subject to reporting under Section 313 (Bromobenzene)
EPA Clean Air Act: Not regulated as a hazardous air pollutant
DSL/NDSL (Canada): Listed
EU REACH Registration: Registered substance
California Proposition 65: Not listed
WHMIS Classification: B2 - Flammable Liquid; D2B - Toxic (skin and eye irritant)
Other Local/National Regulation: Subject to restrictions on handling and use in workplace environments, check country-specific occupational exposure limits and environmental legislation.