Bromoacetic Acid: A Deeper Look at Its Journey, Properties, and Roles Across Science and Industry
Historical Development
Bromoacetic acid has roots going back to the mid-19th century, joining the list of haloacetic acids as organic chemistry gained traction. Chemists first encountered its sharp aroma and curious reactivity soon after learning to make and handle monochloroacetic acid. The replacement of a single hydrogen atom with bromine in acetic acid marked a new pathway in organic synthesis, laying groundwork for future research into more complex halogenated molecules. These discoveries didn’t just make headlines for pure science—they pushed forward advances in pharmaceuticals, dyes, and agricultural practices, setting the tone for upstream chemical industries from Europe to North America. Teachers and researchers alike used it both as an intermediate and a training tool for generations, helping students understand the way functional groups shape chemical properties.
Product Overview
Bromoacetic acid comes off the bench as a clear, slightly oily solid or crystalline powder—depending on how freshly it’s been prepared and the humidity in the lab. It’s got modest popularity, mostly in laboratories or within manufacturing plants feeding the next steps in a chemical synthesis. Industries choose it for its reliable behavior and flexibility in substitution reactions, especially where a single carbon-bromine bond smooths the transfer of the molecule onto new frameworks. Its main strength lies in pulling off transformations that more common acids like acetic and chloroacetic acids struggle to manage.
Physical & Chemical Properties
Anyone who’s handled bromoacetic acid will remember its biting, almost suffocating odor—a solid, yet highly hygroscopic substance with strong corrosiveness. Melting point sits around 50°C; the boiling point pushes just above 200°C, keeping the solid form stable long enough for careful handling. Its density, around 2.0 g/cm³, means it flows and settles differently from water or lighter organic acids. Solubility gives way to clear solutions in both water and ethanol, opening doors for both organic and aqueous chemistry. With a molecular formula of C2H3BrO2 and a molar mass near 138 g/mol, the compound is heavier than its chlorine cousin and brings stronger electron-withdrawing power into reactions.
Technical Specifications & Labeling
Suppliers offer bromoacetic acid in purity grades ranging from technical (above 98%) up to lab reagent standards. Material Safety Data Sheets spell out necessary precautions: it demands acid-resistant gloves, tight-sealing goggles, and good ventilation. Labels highlight hazards—corrosive, toxic, and hazardous to aquatic systems—using both GHS symbols and standardized wording. Most reputable vendors provide a clear certificate of analysis showing batch purity alongside trace metal content and typical levels of water, usually underlining the need for tightly sealed containers.
Preparation Method
The classic method starts with acetic acid or its sodium salt, monochloroacetate. By treating with bromine and a metal catalyst, bromine atoms neatly swap in at the methylene position. Aqueous or organic phase reactions work here: the choice of solvent and temperature determine overall yields and byproduct levels. Students spending time in college labs often experience the process, noting the color shifts and the pungent vapors. Large-scale producers move towards continuous processes for better safety and cost control. By tweaking input ratios and reaction time, industry manages to keep production efficient, limiting waste and side reactions.
Chemical Reactions & Modifications
Bromoacetic acid delivers versatile halogenation—perfect for nucleophilic substitution, where it hands off that bromine to a range of atoms or molecular groups. It’s an old favorite in the Williamson ether synthesis, and it regularly sneaks into peptide coupling, where its active methylene flock latches onto nitrogen, oxygen, or sulfur. Its acidic proton and reactive methylene earn it a place in preparing α-amino acids and other specialty building blocks. Chemists value bromoacetic acid when tackling difficult functionalizations—it acts as a bridge, often the difference between a successful step in a multi-stage drug synthesis and a dead end.
Synonyms & Product Names
You’ll see bromoacetic acid listed under several synonyms, reflecting both its global reach and the changing jargon in scientific circles. It goes by Acetic acid, bromo-; Bromomethanecarboxylic acid; and sometimes as BAA. Chemical suppliers such as Sigma-Aldrich and Merck post both English names and local translations, ensuring clarity for international trade. CAS number 79-08-3 helps labs and factories avoid confusion, especially where other haloacetic acids lurk on the shelf.
Safety & Operational Standards
Handling bromoacetic acid comes loaded with risk: skin contact burns almost instantly, inhalation sears the throat and lungs, and eye exposure leads to severe damage. Chemical fume hoods, acid-resistant PPE, and spill control protocols aren’t optional—they’re the norm. Emergency eyewash stations and showers stand within arm’s reach in well-run labs. Disposal goes through licensed hazardous waste handlers, as standard wastewater streams can’t handle its toxicity or corrosiveness. Direct training for any material transfer or sampling ride high on the compliance list—one slip risks serious injury or facility lockdowns.
Application Area
Scientists and engineers pull bromoacetic acid into several sectors: organic synthesis, crop protection, and specialty pharmaceuticals all see heavy use. It’s a workhorse in the creation of glycine derivatives, N-alkylated proteins, and targets for radiolabeling. In agriculture, derivatives spawn selective herbicides and pesticides, helping manage invasive species with chemical precision. Past experience in the pharmaceutical industry showed me how the compound’s precise chemistry factors into the customization of drug molecules, including anti-cancer agents and enzyme inhibitors. Its clean transfer of the bromo group lets other molecules grab hold, adding to the growing web of modern materials and medicines.
Research & Development
Research teams continue to test bromoacetic acid in ever more complex synthetic routes, from peptide bond formation to radiotracer chemistry. Biochemists look past basic alkylation, exploring it as a probe or a linker for biomolecule tagging. A side interest in academic settings traces the reactivity of the bromine atom, using isotopic versions to map metabolic pathways within small animals or cell cultures. Laboratories blend curiosity-driven projects with industrial goals, seeking better ways to handle and modify bromoacetic acid as new regulatory questions come to the fore. Companies fund collaborations with university chemists, hunting for improvements that streamline manufacturing and reduce environmental footprints.
Toxicity Research
Toxicity data paints a clear warning. Both acute and chronic experiments show bromoacetic acid causes severe injuries at low doses; ingestion, inhalation, or even diluted skin contact result in cellular death, necrosis, and systemic shock. Animal studies suggest mutagenic and organ-damaging effects, while environmental persistence means even trace leaks threaten aquatic life for extended periods. In lab-scale work, we always treated waste streams as hazardous, regardless of dilution. Regulatory bodies press for rigorous reporting, while company safety officers track every mishap or spill. Any newly designed derivative must pass a battery of toxicological screens before gaining widespread approval.
Future Prospects
Industrial demand for specialized building blocks keeps bromoacetic acid in steady production. Synthetic chemists keep it in the toolbox for faster, more selective transformations, and as regulations on safer alternatives bite, companies invest in greener, less hazardous versions. Research trends tilt towards bioconjugation, where precise functionalization aids in tracking biological processes or targeting diseased cells. Some creative projects even use immobilized bromoacetic acid for smarter drug delivery or environmental remediation. The push remains for more sustainable handling and disposal methods; advanced monitoring tech and tighter regulations shape the next era of production. My years watching the compound flow through research, production, and compliance tell me its story is far from finished—strong demand in high-value sectors will keep it relevant as science marches forward.
Chemistry Lab Staple With Real-World Reach
Bromoacetic acid may sound like a tongue-twister only scientists say out loud, but it pops up in research labs for more reasons than its bright chemical profile. I remember my first glimpse of its sharp, vinegary smell—right then, it clicked that behind every odd chemical name there’s a real impact on how we make medicines and understand biology.
Pharmaceuticals Depend On Its Power
Pharmaceutical work relies heavily on the building blocks that small molecules provide, and bromoacetic acid carries a lot of weight here. Chemists use it to modify other molecules, especially to make things like glycine derivatives and special amino acids. These aren’t just esoteric research dead-ends; they feed into drug development pipelines. Think of new antibiotics, cancer treatments, and imaging agents that help doctors see disease—bromoacetic acid is often in the chain somewhere, shaping the active molecules that save or extend lives.
Strength in Chemical Synthesis
The utility of bromoacetic acid goes beyond pills and injections. In organic synthesis, having a molecule with both a carboxylic acid and a bromine atom in such a tight space makes it incredibly valuable. A bromine atom offers a handle for chemists to swap in other groups, allowing them to build up complex molecules from simpler pieces. That’s how new dyes, polymers, and agricultural chemicals get their start. During my time in college, I watched classmates assemble reaction setups built around bromoacetic acid and saw how even a small mistake—spilling or unwanted exposure—could mean a ruined reaction or a push toward greater lab safety awareness.
Research Tool for Biologists
Biology researchers turn to this compound for one surprising application: enzyme inhibition. Bromoacetic acid blocks certain enzymes, making it useful for studying how signals move through cells or how metabolic processes unfold in real time. I once sat through a seminar where a researcher showed fluorescent images of nerve cells treated with bromoacetic acid—activity patterns changed, helping the team understand which enzymes mattered for nerve function. It’s moments like that where academic chemistry connects straight to lessons on disease and health.
Hazards and Handling: A Reality Check
The uses are compelling, but every bottle of bromoacetic acid comes with warning labels for a reason. It can burn the skin and damage organs if not handled properly. My instructor drilled protocol into us: full gloves, fume hood running, never work alone. A compound like this teaches respect for chemistry and reinforces the idea that new materials might solve problems, but only with proper safeguards. In manufacturing settings, chemical plants build in strict controls to limit exposure, and regulations set by groups like OSHA and the EPA guide transportation and storage.
Pushing Toward Safer Alternatives
Concerns about health risks have pushed researchers and industry leaders to hunt for safer alternatives or better handling measures. Green chemistry trends emphasize less hazardous starting materials and push for less toxic byproducts. In my conversations with process chemists, the push toward safety dominates. People want the same power to modify molecules but with less risk to workers or the environment.
Science With Accountability
Bromoacetic acid sits at a crossroads between raw chemical tool and everyday application, always reminding us that with the power to shape molecules comes the responsibility to safeguard our own health and our communities. Every advance in medicine, every new material, carries a trace of simple compounds like this one, pushing the world forward in unseen but important ways.
Why Bromoacetic Acid Demands Respect
Bromoacetic acid grabs attention among laboratory chemicals because it packs a serious punch. Few people outside chemical research circles cross paths with it, and that’s probably for the best. It burns skin, eats through clothing, and delivers some of the nastiest chemical-induced pain to eyes and lungs I’ve seen during my years in the industry. Anyone working around this stuff must come prepared—no shortcuts, no improvisation.
The Risks Lurking with Mishandling
No one wakes up one morning thinking, “I want a trip to the emergency room.” I’ve seen colleagues needing medical help simply because a splash found exposed skin or a fume cloud got loose in a crowded room. Bromoacetic acid isn’t just a routine irritant. Burns from a small spill dig deep. Vapors mess with breathing. A single accident can put a project behind weeks.
Personal Protection Comes First
I always reach for a full set of gear: goggles with face shielding, gloves made for chemical resistance—nitrile or butyl rubber hold up best. Lab coats alone don’t cut it; I wear a splash apron in case a bottle tips over. Never trust regular latex gloves. I’ve watched someone’s latex glove dissolve because bromoacetic acid cut right through in no time.
You can’t skip proper footwear. If it runs onto your shoes, it will burn through to your sock and skin. Shoes need closed toes and a non-absorbent surface.
Engineering Controls — Not Negotiable
Fume hoods make a world of difference. Bromoacetic acid releases fumes, especially once it heats up even slightly, and these eat up mucous membranes fast. Every time I work with it, I check the airflow on the hood before starting. Working outside a hood invites trouble; I’ve seen one small experiment fill up a cramped space with choking fumes faster than expected.
Spill kits shouldn’t collect dust in the corner. Every lab with bromoacetic acid stocked needs kits with neutralizing agents—sodium bicarbonate does the job. I’ve cleaned up enough bench-top messes to know that wiping spilled acid with paper towels doesn’t fix anything.
Storage: Out of Sight, Always Secure
Storing bromoacetic acid on an open shelf is asking for an accident, especially with new students running around. I keep it locked in a corrosion-resistant cabinet, away from bases and incompatible chemicals. Never ignore the label warnings. Every leak chews up shelving and then drips onto the floor, hurting anyone who walks by.
Disposal—Don’t Wing It
Flushing small amounts down a drain used to be common, but I’ve seen what happens next: pipes corrode, fumes build up in plumbing traps, and janitorial staff faces real danger. I always collect residues and tainted tools in designated containers, hand them off to hazardous waste contractors, and track the paperwork. There’s no such thing as “it’ll be fine this time.”
Training and Supervision: Always Essential
People treat new chemicals with care the first time, then get complacent. Oversight keeps mistakes in check. Every workstation serving up bromoacetic acid should include clear working procedures, visual guides on emergency response, and supervisors willing to step in anytime things slip. Safety training once per year doesn’t cut it for new students—refreshers work better.
Why All This Matters
Nothing in a lab happens in isolation. Bromoacetic acid’s risks reach beyond the user. Proper handling protects everyone, from custodians to research partners. The right gear, good habits, and attention to detail make sure that powerful tools like this don't end up causing lasting harm.
What Bromoacetic Acid Means for Health and Safety
Plenty of folks outside a lab won’t come across bromoacetic acid for obvious reasons. This is a potent chemical, not a household name, but its dangers deserve more attention. Bromoacetic acid’s most common use sits in pharmaceutical manufacturing and organic chemistry labs. I came across it in a research internship, and even with gloves, the sting from just a small accidental touch left a mark. That memory sticks: this stuff has real teeth.
Toxicity Isn’t Just Theory
Bromoacetic acid makes itself known quickly. It irritates skin, burns eyes, and triggers respiratory issues with just a whiff. Even a diluted solution can raise welts. Breathing in the vapor, you might notice your chest feels tight or your throat burns. I heard stories from college lab techs who described nausea and dizziness after handling small spills. The Material Safety Data Sheet (MSDS) lists it as both “toxic” and “corrosive.” This isn’t bureaucratic overkill; the acid disrupts cellular processes, so a splash near the eyes or mouth creates problems that escalate fast.
Environmental Danger Lingers
Spilling bromoacetic acid doesn’t just endanger people. This acid leaches into soil and drains into waterways. Wildlife and fish absorb it quickly, leading to poisoning up and down the food chain. Chemists in the know set up spill kits and neutralizers, but even then, cleanup remains a tense process. No one wants this chemical reaching drinking water. A study from the National Center for Biotechnology Information highlights that even low concentrations impair aquatic life.
Why Regulations Matter
Most stories about chemical hazards start with someone cutting corners on storage or disposal. I’ve seen labs store bromoacetic acid in locked cabinets with extra containment trays. Good reason: leaks corrode metal, damage workspaces, and threaten building ventilation. Local and national agencies, like OSHA and the EPA, set strict rules. There’s a logic in that vigilance. Violations often end in fines, or worse, injuries. The CDC notes repeated exposure links to lasting nerve and kidney damage.
How to Handle Bromoacetic Acid Safety
No complicated workaround exists for safety. Labs keep spill kits and eyewash stations ready. Workers wear goggles, thick gloves, and sometimes respirators. Direct experience taught me that even a moment of carelessness means a trip to the nurse. Training runs deep: everyone gets briefed, everyone respects the red hazard symbol. Schools and companies set up periodic safety checks and drills. These precautions stem from lived incidents—once someone gets sick, the protocols start making perfect sense.
Building a Culture of Prevention
If bromoacetic acid were less reactive, maybe safety wouldn’t draw so much focus. Truth is, accidents with small chemicals often lead to big consequences. Routine vigilance, even with small amounts, keeps everyone safe. College labs, government agencies, and research groups all share lessons about mistakes to keep the next crew from repeating them. There’s no substitute for honest warnings and well-stocked safety equipment. Respecting chemicals like bromoacetic acid builds not only better science but safer workplaces for everyone involved.
Why the Details of Simple Chemicals Matter
Bromoacetic acid isn’t something most people think about over breakfast. It pops up in chemistry labs, pops up in textbooks, and sometimes has a quiet role in industries. At a glance, it’s got a not-so-fancy formula: C2H3BrO2. But for anyone who’s spent time hunched over glassware, the story behind that short string of letters and numbers means a lot more. It stands for a basic molecule that can open doors to other discoveries, even to practical changes in fields like medicine and agriculture.
How Bromoacetic Acid Fits Into Daily Life
There’s honest value in asking why folks outside chemistry circles should care about something like bromoacetic acid. This small molecule packs a punch in synthetic chemistry, where it can add pieces to bigger, more useful chemicals. Back in undergraduate organic class, we tried adding a bromine atom to acetic acid in a flask. Then, years later, I flipped through research journals and found that same reaction being used on a much bigger scale in developing medicines.
Every compound on a pharmacy shelf starts as a basic chemical. Bromoacetic acid shows up in the early steps of creating drugs that tackle infections or certain cancers. Its bromine atom, hanging onto that two-carbon backbone, helps build new molecules that end up with antibacterial or anticancer punch. People working in labs depend on details like C2H3BrO2 being right, because mistakes cost money and time—not to mention consumer trust.
Risks and Responsibility in the Lab
The real weight of understanding bromoacetic acid comes from its dual personality. On one hand, it’s a stepping stone to progress. On the other hand, that same reactivity can turn risky. The substance isn’t something you let splash on your skin or sniff. It’s toxic, and in my college’s storeroom, the bottle sat behind glass. We all read those thick safety data sheets before measuring out just a few grams for a reaction.
Regulators and chemical suppliers rely on people knowing exactly what compound they’re handling. Big accidents in labs or factories often come down to mislabeling or carelessness with formulas. There’s no room for mix-ups with something like bromoacetic acid. Understanding its formula isn't just busy work—it's the difference between safe handling and an emergency call.
Stronger Education, Better Chemistry
If more people learn early about the basics—like how a bromine atom swaps places with a hydrogen on the acetic acid molecule—a lot of headaches disappear later. Strong training in recognizing formulas means fewer spills and stronger research. In high school, my science teacher made us memorize not just the formula, but what it actually stood for. Now, with so many chemicals moving through supply chains, this habit’s even more important for keeping workplaces safer and quality higher.
Solutions: Smarter Labeling and Stronger Training
Better labels and software that checks for formula mistakes help keep bromoacetic acid and similar chemicals used properly. Distributors should support training and clear documentation across the whole process, down to the folks carrying crates in warehouses. To build trust and avoid costly recalls, everyone needs to know their C2H3BrO2 from their C2H4O2. With the pace of chemical discoveries growing, attention to detail remains one of the few things that keeps progress safe and steady.
A Hazard Deserves Respect
Bromoacetic acid shows up in labs working with organic synthesis — a small, clear liquid that doesn’t get the same headlines as bigger industrial chemicals. But this stuff isn’t just another bottle on a shelf. It carries serious risks. My own lab days taught me fast: a little bit careless with these sorts of liquids, and somebody gets hurt.
Corrosive, Volatile, and Toxic
A quick spill of bromoacetic acid can burn holes through sleeves. Breathing in even a small amount of vapor makes the lungs sting. Skin contact, even with gloves, calls for immediate washing and often medical attention. Reports from the Centers for Disease Control describe skin necrosis and respiratory irritation linked to poor handling. So, this isn’t just paperwork safety. Bromoacetic acid’s hazard profile has taught thousands of chemists why taking shortcuts with storage comes at a cost.
The Storage Routine That Saves Skin (and Labs)
Years of storing chemicals showed me one clear rule: never treat reactive acids with casual hands. Bromoacetic acid goes straight into a strong, purpose-built container. Polyethylene or glass with airtight, chemical-resistant seals work best — metal seems strong but will corrode quickly.
Acidic fumes creep through loose lids or plastic that’s too soft. A tightly sealed container, clearly labeled, avoids confusion. Don’t stash it next to bases, oxidizers, alcohols, or amines. Those can react and unleash a mess or worse. Separate acid cabinets — not just “some room under the sink” — make all the difference. These cabinets need to stay locked, dry, and heavily ventilated. Chemical safety data sheets and stories from experienced researchers point out explosions and toxic clouds just from improper shelving and mixing.
Temperature and Light Are Enemies
Heat and light boost bromoacetic acid’s volatility and breakdown. I remember a freezer malfunction once — not with bromoacetic acid, but with another volatile acid — and an unnoticed leak cooked through half a cardboard box before anyone found out. Cold, dark storage stays safest. Store at room temperature only if the cabinet is dry and isolated from direct sunlight or heat sources.
People Make the Difference
Young researchers sometimes roll their eyes at the chorus: “Wear the right gloves, goggles, coat.” After a single splatter accident, no one jokes anymore. Personal protective equipment sets the difference between a normal day and a hospital visit. Good training, regular audits, and team awareness stop accidents before they begin. To keep risk low, everyone who deals with bromoacetic acid goes through hands-on drills, not just a paper checklist.
Waste Handling and Spills
After storage comes clean-up. Neutralizing spills with soda ash and scooping waste into designated containers stops corrosive spread. Local fire codes and EPA rules demand proof of safe disposal. Chemical waste contractors provide options for acids and solvents — a single mislabeled jug can shut down an entire lab for days.
Accountability Over Routine
Labs often grow lazy with common reagents, but complacency mixes badly with materials like bromoacetic acid. Witnessing my colleagues learn safety the hard way convinced me: double-checking the simplest things saves careers and sometimes lives. If storage habits slip, risk escalates. We owe it to ourselves, our teams, and the next generation of chemists to keep those storage protocols sharp.


| Names | |
| Preferred IUPAC name | 2-Bromoacetic acid |
| Other names |
BMA
Bromomonoacetic acid Acetic acid, bromo- α-Bromoacetic acid |
| Pronunciation | /ˌbroʊ.moʊ.əˈsiː.tɪk ˈæs.ɪd/ |
| Identifiers | |
| CAS Number | 79-08-3 |
| Beilstein Reference | 1718735 |
| ChEBI | CHEBI:55481 |
| ChEMBL | CHEMBL1357 |
| ChemSpider | 5769 |
| DrugBank | DB02860 |
| ECHA InfoCard | 100.004.126 |
| EC Number | 607-185-00-1 |
| Gmelin Reference | 1766 |
| KEGG | C01698 |
| MeSH | D001947 |
| PubChem CID | 6097 |
| RTECS number | AG8925000 |
| UNII | 5SL0D9T8CY |
| UN number | UN1938 |
| CompTox Dashboard (EPA) | DTXSID7033866 |
| Properties | |
| Chemical formula | C2H3BrO2 |
| Molar mass | 138.948 g/mol |
| Appearance | White to light yellow crystalline solid |
| Odor | Pungent |
| Density | 1.932 g/cm³ |
| Solubility in water | Very soluble |
| log P | -0.37 |
| Vapor pressure | 0.07 mmHg (25°C) |
| Acidity (pKa) | 2.86 |
| Basicity (pKb) | 2.86 |
| Magnetic susceptibility (χ) | -59.5×10⁻⁶ cm³/mol |
| Refractive index (nD) | nD 1.595 |
| Viscosity | 1.72 mPa·s (20 °C) |
| Dipole moment | 2.34 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 143.8 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | −686.6 kJ·mol⁻¹ |
| Std enthalpy of combustion (ΔcH⦵298) | -610.6 kJ/mol |
| Pharmacology | |
| ATC code | D11AX12 |
| Hazards | |
| Main hazards | Toxic if swallowed, causes severe skin burns and eye damage, may cause respiratory irritation. |
| GHS labelling | GHS05, GHS07 |
| Pictograms | GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H301 + H311 + H314: Toxic if swallowed. Toxic in contact with skin. Causes severe skin burns and eye damage. |
| Precautionary statements | P260, P264, P270, P271, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P330, P363, P405, P501 |
| NFPA 704 (fire diamond) | 3-2-2-Acido |
| Flash point | 72 °C |
| Autoignition temperature | Autoignition temperature of Bromoacetic Acid is 370°C |
| Lethal dose or concentration | LD50 oral rat 165 mg/kg |
| LD50 (median dose) | LD50 (median dose): 100 mg/kg (oral, rat) |
| NIOSH | T0303 |
| PEL (Permissible) | PEL: 1 ppm (5 mg/m³) |
| REL (Recommended) | 100 ppm |
| IDLH (Immediate danger) | 50 ppm |
| Related compounds | |
| Related compounds |
Iodoacetic acid
Chloroacetic acid Fluoroacetic acid Acetic acid |