Material Safety Data Sheet for 4-Bromotoluene

Identification

Product Name: 4-Bromotoluene
Synonyms: Para-Bromotoluene, p-Bromotoluene
Chemical Formula: C₇H₇Br
CAS Number: 106-38-7
Recommended Use: Laboratory research, pharmaceutical intermediate, fine chemical manufacturing
Supplier: Details provided by the manufacturer and safety office
Contact Telephone: Emergency and company numbers secured at the workplace
Emergency Overview: Flammable liquid and vapor, potential environmental hazard, respiratory and skin irritant

Hazard Identification

Classification (GHS): Flammable liquids (Category 3), Acute toxicity, Dermal (Category 5), Acute toxicity, Oral (Category 5), Skin irritation (Category 3), Eye irritation (Category 2B), Specific target organ toxicity single exposure
Label Elements: Signal word "Warning," flame symbol, exclamation point
Hazard Statements: Flammable liquid and vapor; May cause skin and eye irritation; Harmful if swalloed or inhaled
Precautionary Statements: Keep away from heat, sparks, and open flame; Use non-sparking tools; Avoid inhalation of dust/vapor; Wear protective gloves, eye protection, and face protection; Take measures against electrostatic discharge
Potential Health Effects: Irritation to skin, nose, or eyes; dizziness or headache through inhalation; possible central nervous system effects if large amounts are inhaled or ingested

Composition / Information on Ingredients

Chemical Name: 4-Bromotoluene
Concentration: 98% or higher
CAS Number: 106-38-7
Impurities: Trace toluene, isomers below 2%, common halogenated byproducts traceable upon analysis
Hazardous Components: Substance qualifies as hazardous under OSHA and EC classification systems

First Aid Measures

General: Move affected person to fresh air, remove contaminated clothing, offer reassurance
Eye Contact: Rinse opened eyes cautiously with water for at least 15 minutes, keep eyelids apart, seek medical advice if irritation persists
Skin Contact: Wash area thoroughly with soap and water, remove any contaminated clothing, seek medical attention for persistent irritation
Inhalation: Remove person from exposure, keep comfortable in position for breathing, provide artificial respiration if not breathing, seek immediate medical care for acute effects
Ingestion: Rinse mouth with water without swallowing, offer water to drink if conscious, never give anything by mouth to an unconscious person, seek medical advice if symptoms develop
Notes to Physician: Treat symptomatically, monitor respiratory and cardiac function, provide supportive care

Fire-Fighting Measures

Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam, water spray
Fire Hazards: Vapors may form explosive mixture with air, may travel to ignition source then flash back
Special Protective Equipment: Wear self-contained breathing apparatus and protective clothing
Hazardous Combustion Products: Hydrogen bromide gas, carbon monoxide, carbon dioxide, various organic compounds
Advice for Firefighters: Cool exposed containers with water spray, avoid inhaling combustion gases
Unusual Fire Explosions: Closed containers may explode under extreme heat, move containers from fire area if it’s safe

Accidental Release Measures

Personal Precautions: Evacuate non-essential personnel, ventilate area, avoid inhalation or contact with skin
Protective Equipment: Chemical splash goggles, chemical-resistant gloves, appropriate respirators based on concentration
Spill Cleanup: Absorb liquid on inert material (sand, earth), sweep up, place in suitable waste container for disposal
Environmental Precautions: Prevent release into drains or watercourses, alert authorities if major spillage occurs
Decontamination: Wash spill site thoroughly after cleanup, ensure all residues are removed, handle as chemical waste

Handling and Storage

Handling: Use only in well-ventilated fume hoods, avoid inhalation of vapors, prevent skin and eye contact
Avoidance: Keep away from sources of ignition, avoid static discharge, use grounded equipment
Safe Storage: Store in tightly sealed containers, keep in cool, dry, well-ventilated places, protect from light and incompatible substances like strong oxidizers or acids
Transport Containers: Use containers that are chemically compatible and clearly labeled
Incompatibility: Avoid oxidizing agents, strong acids, alkali metals, peroxides
Other Precautions: Store separately from food or animal feed, follow local regulations concerning storage

Exposure Controls and Personal Protection

Exposure Limits: No exposure limits established by OSHA, ACGIH, or NIOSH; minimize airborne concentration
Engineering Controls: Mechanical exhaust, laboratory fume hood, local ventilation; handle in closed systems where possible
Respiratory Protection: Use NIOSH/MSHA approved respirators for organic vapors if exposure exceeds recommendations
Hand Protection: Wear nitrile or neoprene gloves
Eye Protection: Safety goggles or chemical splash goggles
Skin and Body Protection: Lab coat, apron, closed-toe chemicals resistant shoes

Physical and Chemical Properties

Appearance: Clear to slightly yellow liquid
Odor: Like aromatic hydrocarbons
Boiling Point: 184–186°C (363°F)
Melting Point: -7°C (19°F)
Flash Point: 57°C (135°F)
Auto-Ignition Temperature: Data not provided
Vapor Pressure: Approx. 1 mmHg at 20°C
Solubility: Insoluble in water, soluble in ethanol, ether, and organic solvents
Density: 1.47 g/cm³
Partition Coefficient (octanol/water): Log Kow 3.9
Viscosity: Not specified
Explosive Properties: Not classified as explosive, vapors can form explosive mixtures with air

Stability and Reactivity

Stability: Stable under standard storage and handling conditions
Conditions to Avoid: Excessive heat, open flame, sources of ignition, strong light exposure
Incompatible Materials: Oxidizing agents, bases, metals, peroxide-forming substances
Decomposition Products: May release hydrogen bromide, carbon oxides, toxic fumes on combustion
Polymerization: Not known to polymerize under normal conditions
Reactivity: Can react with strong oxidizers and bases, may also interact with some reducing agents

Toxicological Information

Acute Toxicity: LD₅₀ (oral rat) estimated at >2000 mg/kg; not classified as acutely toxic
Chronic Toxicity: Prolonged exposure may cause dermatitis or sensitization, data scarce for long-term effects
Routes of Exposure: Inhalation, dermal contact, ingestion
Immediate Effects: Mild irritation to skin, eyes, and respiratory tract; possible headaches, nausea, central nervous system effects if inhaled in large amounts
Carcinogenicity: No data suggesting carcinogenic potential in IARC or ACGIH listings
Mutagenicity/Reproductive Effects: No relevant animal or epidemiological data found

Ecological Information

Ecotoxicity: Toxic to aquatic organisms with long-lasting effects, even at low concentrations
Persistence and Degradability: Not readily biodegradable; persistent in soil and sediments
Bioaccumulative Potential: Moderately bioaccumulative due to high log Kow
Mobility in Soil: May adsorb to soil particles, low leaching potential into groundwater
Aquatic Toxicity: Data suggests LC₅₀ in fish or daphnia in low mg/L range
Other Harmful Effects: Avoid all release to water bodies or sewage system, significant and cumulative effects possible

Disposal Considerations

Waste Treatment: Dispose through licensed hazardous chemical disposal contractor
Waste Code: Appropriate RCRA code or local equivalent applies, treat as halogenated organics
Packaging: Dispose of as contaminated chemical waste, do not reuse containers
Precautions: Avoid contact with solid or liquid waste; incineration in controlled, permitted facilities; do not flush to sewer or environment

Transport Information

UN Number: UN 1993
UN Proper Shipping Name: Flammable Liquid, N.O.S. (contains 4-Bromotoluene)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Labels Required: Flammable liquid label, hazard class label and information per IATA/IMDG/ADR
Special Precautions: Protect from physical damage; ensure upright position; comply with local and international transport regulations

Regulatory Information

US TSCA: Listed on Toxic Substances Control Act Inventory
OSHA Status: Hazardous chemical according to OSHA HazCom Standard
SARA Title III: Section 313 reporting not required; not on Extremely Hazardous Substances list
California Prop 65: Not listed as a known carcinogen or reproductive toxin
REACH Status (EU): Pre-registered, check latest inventory for updates
Other Country Regulations: Check national and provincial regulations before handling or transport; not subject to import/export bans in major chemical markets
Labeling Requirements: GHS-compliant hazard and precautionary statements, provider identity, and chemical identification required on all packages