Material Safety Data Sheet: 4-Bromofluorobenzene

Identification

Product Name: 4-Bromofluorobenzene
Synonyms: p-Bromofluorobenzene, 1-Bromo-4-fluorobenzene
CAS Number: 460-00-4
Recommended Use: Chemical intermediate, laboratory reagent
Manufacturer: Chemical supplier details listed on packaging
Emergency Contact: Available through manufacturer and local safety data services
Product Code: Refer to supplier’s catalog; often BG05642

Hazard Identification

GHS Classification: Flammable Liquid (Category 3), Acute Toxicity Oral (Category 4), Skin and Eye Irritant
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor. Harmful if swallowed. Causes mild skin irritation. May cause irritation to eyes and respiratory tract.
Pictograms: Flame, Hazard exclamation
Precautionary Advice: Keep away from heat, sparks, open flames. Avoid breathing vapors, mist, or spray. Use protective gloves, eyewear, and clothing. Wash hands thoroughly after handling.
Potential Health Effects: Inhalation and ingestion cause headaches, nausea, and respiratory discomfort. Prolonged or repeated exposure may affect central nervous system.

Composition / Information on Ingredients

Chemical Name: 4-Bromofluorobenzene
Chemical Formula: C6H4BrF
Molecular Weight: 175.00 g/mol
Concentration: >99% (typically supplied as pure compound)
Impurities: Trace amounts of related halogenated benzenes and residual solvents below regulatory thresholds
Ingredient EINECS Number: 207-305-5

First Aid Measures

Inhalation: Move to fresh air. If symptoms persist, seek medical attention. Give oxygen if breathing becomes difficult. Monitor for cough, headache, or shortness of breath.
Skin Contact: Remove contaminated clothing. Wash skin with plenty of water and soap, scrub gently to remove material. Obtain medical help if irritation or redness develops.
Eye Contact: Rinse thoroughly with water for several minutes, lifting eyelids. Remove contact lenses if present and easy to do. Continue to flush and seek medical evaluation if pain or visual disturbance remains.
Ingestion: Rinse mouth. Never induce vomiting unless directed by medical personnel. Seek prompt medical advice. If conscious, offer a small amount of water.

Fire-Fighting Measures

Flammability: Liquid and vapors are combustible
Suitable Extinguishing Agents: Dry chemical powder, alcohol-resistant foam, carbon dioxide. Water spray only for cooling containers and dispersing vapors.
Hazardous Combustion Products: Hydrogen bromide, hydrogen fluoride, carbon monoxide, irritating and toxic fumes
Specific Hazards: Vapors form explosive mixtures with air. Containers may burst in heat of fire. Runoff may pollute waterways.
Protective Equipment for Firefighters: Full protective clothing, positive pressure self-contained breathing apparatus (SCBA)
Firefighting Advice: Use water to keep fire-exposed containers cool. Avoid breathing vapors, gases, or mist. Contain water runoff to prevent environmental contamination.

Accidental Release Measures

Personal Precautions: Evacuate unnecessary personnel, ventilate area, use personal protective equipment including gloves, goggles, and respirators suitable for organic vapor.
Environmental Precautions: Prevent entry into drains, soil, and waterways. Alert local authorities if spillage results in contamination of environment.
Cleanup Methods: Absorb spill with inert material (vermiculite, sand). Sweep up with non-sparking tools. Transfer to container for disposal. Wash spill site after cleaning.
Waste Disposal: Dispose of in compliance with local and national regulations.

Handling and Storage

Safe Handling: Work in well-ventilated areas, preferably under chemical fume hoods. Avoid inhalation, ingestion, and prolonged skin contact. Use grounded equipment to avoid static buildup.
Storage Conditions: Store tightly sealed in cool, dry locations away from direct sunlight and ignition sources. Store separately from oxidizers and acids. Use proper chemical storage cabinets.
Incompatible Materials: Strong oxidizing agents, reducing agents, acids
Special Storage Guidance: Label containers clearly, keep away from food and beverages. Restrict access to trained personnel.

Exposure Controls and Personal Protection

Engineering Controls: Chemical fume hood, local exhaust ventilation, automated transfer systems to reduce vapor exposure
Exposure Limits: No established OSHA or ACGIH exposure limits; minimize exposure as much as possible
Personal Protective Equipment (PPE): Lab coat, flame-resistant apron or suit, nitrile or neoprene gloves, protective goggles (ANSI Z87 compliant), face shield in splash scenarios
Respiratory Protection: NIOSH-approved organic vapor respirators if ventilation is inadequate
Hygiene Measures: Avoid eating, drinking, smoking while handling. Wash thoroughly after use. Promptly remove contaminated clothing.

Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid
Odor: Faint aromatic odor
Odor Threshold: Not determined
pH: Not applicable
Melting Point: -11°C
Boiling Point: 155-158°C
Flash Point: 47°C (closed cup)
Evaporation Rate: Not determined
Flammability: Flammable liquid
Vapor Pressure: 5 mmHg at 25°C
Vapor Density: 6 (air=1)
Relative Density: 1.571 g/cm³
Solubility: Insoluble in water; soluble in organic solvents like ethanol, ether, and benzene
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: 400°C
Decomposition Temperature: Not specified
Viscosity: Not determined

Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures
Reactivity: Not prone to hazardous reactions under recommended handling procedures
Conditions to Avoid: Heat, sparks, flames, static discharge, direct sunlight
Incompatible Materials: Oxidizing agents, strong acids or bases
Hazardous Decomposition Products: Hydrogen bromide, hydrogen fluoride, carbon monoxide, carbon dioxide, other toxic gases
Polymerization: Not expected

Toxicological Information

Acute Toxicity: May cause nausea, headache, dizziness if inhaled or ingested in moderate quantities; oral LD50 (rat): >2000 mg/kg.
Skin Irritation: Mild irritation possible; prolonged contact may produce dermatitis symptoms.
Eye Irritation: Irritating, causes redness, watering, or blurred vision on direct contact.
Chronic Effects: Prolonged or repeated exposure may cause kidney, liver, or neurological effects, particularly with poor handling.
Sensitization: No evidence of respiratory or skin sensitization observed in animal studies.
Mutagenicity/Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA; genotoxic data not sufficient.
Further Health Effects: High concentrations may cause depression of the central nervous system.

Ecological Information

Ecotoxicity: Harmful to aquatic life, with possible bioaccumulation in water organisms; should not be released into environment.
Persistence and Degradability: Expected to be persistent; slow biodegradation under natural conditions.
Mobility in Soil: Moderately mobile; potential for leaching into groundwater.
Bioaccumulative Potential: May accumulate in aquatic species due to high partition coefficient.
Other Adverse Effects: Toxic to fish and invertebrates at moderate concentrations; unknown impact on terrestrial birds and mammals.

Disposal Considerations

Disposal Methods: Dispose of contents through a licensed chemical waste disposal contractor. Follow all local, state, and federal laws.
Container Disposal: Triple rinse containers before discarding. Deface labels and destroy containers so that unauthorized users cannot repurpose.
Precautions for Disposal: Do not discharge into drains, soil, or surface water. Do not attempt to incinerate in open air.
Recommended Treatment: High temperature incineration at facilities equipped for halogenated organics.

Transport Information

UN Number: UN1993
Proper Shipping Name: Flammable Liquid, N.O.S. (contains 4-Bromofluorobenzene)
Transport Hazard Class: 3 (Flammable liquids)
Packing Group: III
Labels Required: Flammable liquid
Special Transport Measures: Secure upright, away from oxiders and incompatible materials, special containment for bulk shipping; follow all guidelines for hazardous chemical transport.
Marine Pollutant: Expected to be hazardous to marine life; do not allow material to enter the environment during shipment.

Regulatory Information

Safety, Health and Environmental Regulations: 4-Bromofluorobenzene appears on TSCA Inventory. Not specifically listed under SARA Title III, Section 313 or CERCLA. Subject to OSHA regulations as a hazardous chemical.
WHMIS Classification (Canada): B2 (Flammable liquid), D2B (Toxic material causing other effects)
Labeling Requirements: GHS hazard pictograms and signal words, full hazard statements on all workplace tanks, drums, and secondary containers.
REACH Status (Europe): Registered or pre-registered, handled according to standard chemical handling protocols.
California Proposition 65: Not listed
International Regulations: Complies with major chemical safety regulations in North America, Europe, and other jurisdictions.