Material Safety Data Sheet: 3-Bromochlorobenzene

Identification

Product Name: 3-Bromochlorobenzene
Chemical Formula: C6H4BrCl
CAS Number: 591-17-3
Other Names: m-Bromochlorobenzene, 1-Bromo-3-chlorobenzene
Recommended Use: Laboratory chemicals, synthesis of pharmaceuticals, chemical research
Supplier Details: Manufacturer name and address, phone number for emergencies, contact information for safety support
Emergency Phone Number: CHEMTREC or local equivalent provided for rapid support in case of incidents or exposure

Hazard Identification

GHS Classification: Acute toxicity (oral, dermal, inhalation), skin and eye irritation, aquatic environmental hazard
Signal Word: Warning
Pictograms: Skull and crossbones, exclamation mark, environment
Hazard Statements: Harmful if swallowed, causes skin irritation, may cause respiratory irritation, toxic to aquatic life with long-lasting effects
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, use only outdoors or in a well-ventilated area, avoid release to environment
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Potential Effects: Irritation to skin, eyes, mucous membranes, headaches, dizziness

Composition / Information on Ingredients

Chemical Name: 3-Bromochlorobenzene
Concentration: More than 99% pure
CAS Number: 591-17-3
Impurities: Trace halogenated benzenes under 0.5%
Additives: No stabilizers or solvents included

First Aid Measures

Inhalation: Move person into fresh air immediately, keep comfortable for breathing, seek medical advice for ongoing symptoms such as coughing, dizziness, or headaches
Skin Contact: Remove contaminated clothing, rinse affected skin with large amounts of water and mild soap, seek medical advice if irritation or redness continues
Eye Contact: Rinse with clean running water for several minutes, remove contact lenses if present and easy to do so, continue rinsing, consult medical professional if pain or visual changes persist
Ingestion: Rinse mouth thoroughly with water, avoid inducing vomiting, seek immediate medical attention if large amounts have been swallowed or if symptoms develop
Self-Protection for First Aiders: Use gloves, goggles, and suitable respiratory protection before assisting exposed individuals

Fire-Fighting Measures

Suitable Extinguishing Media: Carbon dioxide, dry powder, foam, water spray
Unsuitable Media: Do not use direct water jet on burning material
Specific Hazards: May release toxic and irritating vapors such as hydrogen chloride, bromine, and phosgene during combustion, intensifying the fire due to volatility
Advice for Firefighters: Use full protective clothing with self-contained breathing apparatus, avoid inhaling fumes, contain runoff to prevent environmental spread
Thermal Decomposition: Produces dense fumes, fire can escalate quickly in confined spaces, so evacuate and ventilate as necessary

Accidental Release Measures

Personal Precautions: Wear barrier gloves, chemical splash goggles or face shield, and chemical-resistant clothing
Environmental Precautions: Prevent entry into soil, waterways, or drains using containment diking or inert absorbent material
Spill Cleanup: Ventilate area, avoid creating dust, collect solid spill with inert absorbent, place in sealed chemical waste container for disposal
Decontamination: Clean surface with soapy water after material removal, ensure all residues are transferred to waste disposal container
Further Actions: Notify local safety or environmental authorities if spillage threatens public safety or environment

Handling and Storage

Safe Handling: Use in chemical fume hood, avoid inhaling dust or vapors, keep away from food, beverages, and incompatible materials such as strong oxidizing agents
Hygiene Practices: Wash hands and face thoroughly before eating, drinking, or smoking; do not touch face while handling
Storage Requirements: Store in tightly closed containers away from direct sunlight, in a cool, dry, and well-ventilated space, out of reach of incompatible substances
Incompatible Materials: Strong oxidizers, alkali metals, open flame; store away from sources of ignition and static discharge

Exposure Controls and Personal Protection

Control Parameters: No occupational exposure limits established by OSHA, ACGIH, or NIOSH for 3-Bromochlorobenzene
Engineering Controls: Work under fume hood with good local exhaust ventilation
Personal Protective Equipment: Safety goggles or face shield for eye protection, nitrile or neoprene gloves, lab coat or coveralls, and chemical-resistant shoes
Respiratory Protection: Use suitable respirator if aerosol or vapor is generated above safe handling practices
Environmental Controls: Prevent migration into the environment, monitor air quality if handling large quantities

Physical and Chemical Properties

Appearance: Clear, colorless to pale yellow liquid
Odor: Faint aromatic odor
Melting Point: 7 – 10 °C
Boiling Point: 220 – 223 °C
Relative Density: 1.62 g/cm³ at 25 °C
Solubility: Practically insoluble in water, readily dissolves in organic solvents such as ether, acetone, benzene
Vapor Pressure: Low vapor pressure under standard conditions
Flash Point: 93 °C (closed cup)
Stability in Light and Air: Stable at room temperature under recommended storage conditions, can slowly degrade with prolonged exposure to sunlight or air
Evaporation Rate: Slow, non-volatile at standard temperature

Stability and Reactivity

Chemical Stability: Stable under normal temperature and pressure in tightly sealed containers
Incompatible Materials: Vigorous reactions with strong oxidizers and alkali metals, may react directly with reducing agents leading to hazardous byproducts
Decomposition Products: Heating or burning can produce hazardous vapors such as hydrogen chloride, carbon monoxide, hydrogen bromide, and phosgene
Hazardous Polymerization: Will not occur under recommended handling procedures
Conditions to Avoid: Excessive heat, open flames, sources of ignition, prolonged exposure to light or moist air

Toxicological Information

Possible Health Effects: Inhalation may produce coughing, throat and lung irritation, headaches, and dizziness; skin contact causes redness and dryness; eye exposure results in burning and tearing; ingestion can produce abdominal pain, nausea, or vomiting
Acute Toxicity: Oral LD50 (rat): 3200 mg/kg; Dermal LD50 (rabbit): information limited, expected to show moderate toxicity
Chronic Effects: Long-term or repeated exposure could cause liver or kidney damage based on similar halogenated aromatic compounds
Carcinogenicity: Not classified as a known human carcinogen by IARC, NTP, or OSHA
Sensitization: Unlikely based on available studies, but repeated contact may increase risk
Mutagenicity/Teratogenicity: Limited data, no clear evidence of reproductive or mutagenic risks

Ecological Information

Ecotoxicity: Highly toxic to aquatic life, may cause long-term adverse effects in aquatic environments due to persistence and potential bioaccumulation in fish or invertebrates
Mobility in Soil: Low water solubility and high adsorption indicate limited mobility in terrestrial environments
Degradability: Resistant to microbial degradation, persists in soil and sediment for extended periods
Bioaccumulation: Potential to bioaccumulate in organisms, especially aquatic species
Additional Information: Avoid release to the environment; spill and waste management focus on containment and professional disposal
Regulatory Notes: Severe penalties in some jurisdictions for environmental contamination incidents

Disposal Considerations

Disposal Methods: Handle all waste material as hazardous waste, incinerate under controlled conditions through licensed chemical waste disposal contractor
Contaminated Packaging: Decontaminate containers before recycling or disposal, follow local and national regulations governing hazardous containers
Special Precautions: Avoid release to sewage systems or open environment, document and secure all material sent for disposal
Legal Requirements: Strict record-keeping and manifesting required under RCRA and local equivalents, with fines for improper disposal

Transport Information

UN Number: UN 3082 (Environmentally hazardous substance, liquid, n.o.s.)
Transport Hazard Class: 9 (Miscellaneous Dangerous Substances and Articles)
Packaging Group: III
Labels Required: Environmental hazard, miscellaneous dangerous goods
Transport Requirements: Use UN-tested, leak-proof containers, follow ADR/RID/IMDG/IATA rules, avoid mixed loads with incompatible materials
Emergency Response: Trained personnel only, with access to spill containment and emergency communication equipment

Regulatory Information

TSCA (US): Listed
REACH (EU): Subject to registration, compliance with SVHC (Substances of Very High Concern) notifications
OSHA: Considered hazardous chemical, triggers workplace safety and hazard communication requirements
EPA: Classified as hazardous waste, notification required for significant spills
Other Regulations: Covered by various state and local regulations for chemical storage, labeling, employee exposure
Workplace Labeling: GHS-compliant labels required at all transfer or point-of-use containers