3-Bromochlorobenzene: A Practical Examination
Historical Development
3-Bromochlorobenzene found its way into the chemical landscape during the early twentieth century, a time when synthetic chemists got their hands dirty chasing new aromatic substitution strategies. Back then, industries and university labs searched for ways to modify simple benzene rings with different halogens. People like Sandmeyer and his peers opened doors by demonstrating how substituents like bromine and chlorine could be introduced onto aromatic cores under different reaction sets. Over time, this compound popped up in reaction manuals and research journals wherever researchers outlined methods involving sequential halogenations or the manipulation of anilines. The push for more targeted halogenated intermediates probably came from young chemical companies eager to feed the growing demand for new polymers, agrochemicals, and dyes. Over several decades, refinements in regioselectivity, purification, and scale-up meant places with strong chemical manufacturing bases, especially in Europe and the U.S., kept 3-bromochlorobenzene close at hand as a flexible building block.
Product Overview
3-Bromochlorobenzene has made itself indispensable within specialty chemicals, pharmaceutical precursors, and even certain high-performance material routes. It shows up as a pale liquid or a faintly crystalline solid at room conditions, depending on grade and storage temperature. On my first encounter, I noticed a striking halogen odor—a sharp, chemical tang familiar to anyone who ever spent time decanting halogenated liquids in university fume hoods. Many suppliers list it for lab and industrial use under varied SKUs, typically distinguished only by purity, halide source, or region. Chemical catalogs and technical data sheets highlight its reliability in Suzuki, Stille, and Heck couplings, reminding users of its value for adding complexity onto simple rings without fuss.
Physical & Chemical Properties
This compound presents itself with a melting point that floats around 7°C, and it boils between 205-210°C. Its density, almost 1.7 g/cm³, makes it heavier than water, and much denser than aromatic hydrocarbons lacking halogen atoms. The molecular formula C6H4BrCl results in a molecular weight close to 191.46 g/mol, giving the compound some heft for its size. Its low solubility in water contrasts with its high solubility in non-polar organic solvents, which makes extractions and purifications more straightforward for those in organic synthesis labs. Chemists who favor practical routine know that aromatics like this shrug off air and light, so long as one avoids bases or powerful nucleophiles. Stability remains a strong suit unless you push it hard with reductive or metal-promoted conditions.
Technical Specifications & Labeling
Top suppliers take care to specify purity—usually not less than 98%—alongside limits for moisture, isomeric content, and trace metals. Labels address both CAS Registry Numbers and EC list designations. The packaging outlines shelf life, storage advisories (keep away from direct sunlight and moisture, keep tightly sealed), plus details from local hazard comms—'harmful if inhaled or ingested' appears on the first line. Pictograms highlight flammability and acute toxicity risks. Clear hazard and precaution statements, dictated by international norms, remind every user to don gloves, safety glasses, and work in a ventilated enclosure. Lot-specific test certificates sometimes drill all the way down into GC-MS traces and UV/Vis absorption data if customer requests call for it.
Preparation Method
Most industrial syntheses aim for cost efficiency and high yield, starting with monochlorobenzene or bromobenzene routes. One common approach: start with chlorobenzene, add bromine in the presence of an iron catalyst so that bromination lands on the meta position, thanks to the directing effects of chlorine. Lab chemists often set temperatures between 0°C and 10°C to curb dihalogenation, adding bromine slowly and stirring for hours. After the main reaction, washing with dilute NaHSO3 and water removes excess bromine and iron species. Distillation under reduced pressure sorts out the product from minor isomers. Another popular alternative takes 3-chloroaniline through diazotization (using sodium nitrite and hydrobromic acid), followed by Sandmeyer bromination. Between these two, operators weigh tradeoffs between cost, waste management, and the specific isomer profile needed for downstream reactions.
Chemical Reactions & Modifications
Lab workers and industrial chemists both depend on 3-bromochlorobenzene when they need to hook up new structures via cross-coupling chemistry. Palladium-catalyzed Suzuki reactions with boronic acids make new biaryl motifs possible, fueling drug discovery and material science. It takes part in Sonogashira couplings for those building alkynes into larger architectures, adding rigidity and new reactivity. Stille and Buchwald-Hartwig aminations ride on the selective reactivity of the bromine atom, which usually leaves before the less-activated chloride. I’ve seen colleagues use this selectivity to create orthogonally functionalized rings, inserting amines or aryl groups first through the bromine, saving the chloride for late-stage modification under stronger conditions. Hydrogenation strips off either halogen, depending on catalyst and pressure, while halogen-metal exchange (with strong organolithium reagents) lets chemists skip to another functional handle.
Synonyms & Product Names
3-Bromochlorobenzene answers to several monikers: 1-Bromo-3-chlorobenzene crops up most often in formal literature, with the CAS registry number 108-37-2 as its chemical fingerprint. Other trade names show up: meta-bromochlorobenzene, 3-chlorophenyl bromide, or simply m-bromochlorobenzene on supplier lists. Multinational distributors may slip in translations or shorthand specific to labeling rules in Japan and the EU, but purity and composition take priority over lexical quirks—buyers still recognize what matters inside the bottle.
Safety & Operational Standards
Factory-scale operators and researchers alike respect the health hazards found with halogenated benzenes. Gloves rated for organic solvents and splash-proof goggles matter from the first weigh-out to the final transfer. Prolonged skin contact leads to irritation, and inhaling vapors over time can spark respiratory discomfort, echoing what many workers experience with most low-boiling aromatics. Most SDS sheets list occupational exposure limits based on animal studies and decades of chemical hygiene manuals. Good practice keeps the work inside a ventilated hood—not just for vapor containment but to limit fire risk, since the compound has a flash point near 80°C. Strong oxidizers, bases, or alkali metals in the same workspace deserve extra attention. Spills get covered with inert material, swept up, and transferred for hazardous waste incineration. Emergency eyewash stations and spill kits complete the basic safety layout.
Application Area
Few building blocks in modern chemistry compete with the utility offered by 3-bromochlorobenzene. Pharmaceutical companies rely on it as a precursor for several antihistamine, antipsychotic, and antimicrobial candidates—the meta substitution allows for careful regioselective elaborations. Agrochemical research draws from it for new herbicide and insecticide candidates, exploiting the electron-rich aryl ring to optimize pesticide binding sites. Polymer scientists tap into its double halide functionality for co-polymerization efforts or for tuning flame retardancy, a persistent concern in engineered plastics. Materials chemists value its role as a starting block for liquid crystal syntheses, giving display and sensor manufacturers more tunability as they push for sharper screens and new flexible electronics. Academic labs incorporate it into undergraduate synthetic methods courses, so students gain hands-on familiarity with halogen handling, purification, and NMR interpretation.
Research & Development
Researchers continue expanding the synthetic repertoire with 3-bromochlorobenzene, especially as new catalysts and reaction methodologies emerge. Academic papers pile up around selective halogen exchange, metal-free coupling reactions, and green chemistry approaches that limit waste byproducts—topics close to my own graduate work in synthetic methodology. Industry groups chase after next-generation cross-coupling catalysts that slash costs or operate at lower temperatures, making large-scale modifications more sustainable. Startups with a focus on flow chemistry and continuous manufacturing use this molecule as a test substrate, showing off the efficiency and scalability of their reactors. In the computational chemistry world, electronic structure calculations on halogenated benzenes shape new ways to predict bioactivity and binding for drug discovery, speeding up early-phase screening before anyone lifts a flask.
Toxicity Research
Studies have shown that aromatic halides like 3-bromochlorobenzene share certain toxicological features: moderate acute toxicity, the potential for skin and eye irritation, and chronic effects driven by repeated exposure. Animal studies reported CNS depression and some evidence of liver and kidney stress, prompting regulatory oversight for workplace exposure. Research teams in environmental chemistry have measured trace persistence in soil and water, noting the compound's resistance to biodegradation. Advanced GC-MS and HPLC techniques helped trace its metabolic fate, showing it converts in vivo to phenolic and hydroxy derivatives with higher water solubility. Efforts in the last decade aimed to map out biodegradation by soil bacteria; a handful of engineered strains can cleave halogenated aromatics, but their practical deployment remains rare. Chemical safety professionals write exposure assessments and recommend limits in place—lab air monitoring, eye protection, and fume hoods figure into daily protocol for anyone handling this compound.
Future Prospects
Industry demand for new pharmaceutical and materials applications keeps 3-bromochlorobenzene in the chemical toolkit. The move toward sustainable processes means catalyst and solvent choices keep evolving, and researchers look for ways to cut out hazardous waste by designing neater, cleaner, and more atom-efficient transformation routes. As regulatory landscapes grow stricter across the globe, more production will rely on closed-loop systems, recycling solvents and minimizing emissions during manufacturing. Advances in continuous flow chemistry seem poised to deliver this compound at commercial scale with improved safety profiles and tighter product quality metrics. High-throughput screening and machine learning platforms will likely discover unimagined synthetic opportunities or guide its use in target-based drug design, where every atom counts. What started as a simple halogenated aromatic now stands at the intersection of legacy chemistry and modern innovation, ready for whatever the next generation of scientists and engineers decides to build from it.
Understanding What 3-Bromochlorobenzene Is
Inside chemistry labs, 3-bromochlorobenzene regularly shows up as a halogenated aromatic compound. Looking at the molecules, you get a benzene ring, a common playground for many chemical syntheses. In this specific case, two different halogens hang on the ring: bromine and chlorine. They don't sit next to each other. Instead, they stick to the ring at positions separated by one carbon, which gives us the “3-” prefix.
Breaking Down the Structure
Imagine the classic hexagon of benzene — six carbon atoms, each bonded, forming a flat ring. Every carbon connects to a hydrogen, but in 3-bromochlorobenzene, two hydrogens step aside. Bromine takes the first spot (position 1) and chlorine drops into position 3 if you count around the ring. Chemists often draw it as C6H4BrCl, with those halogens making the molecule more reactive than plain old benzene.
An Everyday Example from the Lab
Years ago, fresh out of school, the first actual chemical synthesis I tried that felt “real world” involved halogenated benzenes. The difference between compounds like 3-bromochlorobenzene and its cousins becomes obvious if you handle them. Some are more volatile, others act differently under UV or react faster. The substitution pattern doesn’t just look pretty on paper — it shapes reactivity and opens doors for building more complex molecules.
Why Structure Shapes Everything
Research in pharmaceuticals relies on these details. The spot where a halogen sticks onto a benzene ring can flip the biological activity of a drug. One pattern might slip through the body unnoticed; swap a halogen to a different spot, and suddenly you find a potent medicine. 3-bromochlorobenzene sometimes works as a building block. Chemists use it to stitch together newer molecules, especially when searching for improved drug candidates or specialty materials. The way those two halogens pull electrons changes the molecule’s behavior, not just in the test tube but wherever derivatives land in real products.
Handling and Safety Matter
Halogenated benzenes, 3-bromochlorobenzene included, often pose toxicity and environmental concerns. In my own experience, caution ruled every step. The compound isn’t something to rinse down the drain or leave open on a bench. Small spills or careless disposal add up in the real world, especially in labs that run every day. Good practices help limit human exposure and stop environmental contamination, and they don’t take much–gloves, a fume hood, and a bit of common sense go a long way.
Towards Greener Chemistry
Moving green in chemistry means less waste and safer chemicals. The unique pattern of halogens on 3-bromochlorobenzene, though useful, asks for extra thought about what happens after lab work ends. Some research pushes for new ways to separate or recycle halogenated compounds. Trying catalytic methods that allow recovery or breakdown of such molecules can lessen their impact. Supporting policies that look at the full life cycle—production, use, and disposal—adds up, especially for widely-used intermediates like 3-bromochlorobenzene.
How Knowledge Drives Better Industry Choices
The more fully we grasp the ins and outs of these chemical structures, the stronger our foundation for making smarter, safer products. Every detail, every lab lesson, builds toward that world—one where understanding of molecules like 3-bromochlorobenzene doesn’t just fuel curiosity, but shapes responsible science and technology for the future.
Chemical Building Block in Pharmaceutical Synthesis
3-Bromochlorobenzene enters most conversations in synthetic chemistry labs as a starting point. In my work with researchers, nearly every custom compound project rests on finding stable, easy-to-handle molecules that lend themselves to all kinds of modifications. This molecule provides exactly that. Its stable ring attracts researchers who want to create intermediates for antihistamines, pain relievers, and antipsychotic drugs. The bromine and chlorine atoms hang onto the ring in a way that boosts versatility—those positions get swapped or modified using well-known coupling reactions. Top journals often feature examples where a lab has begun with 3-Bromochlorobenzene and, after working through a few steps, landed on something with real-world medical value.
Intermediate in Agrochemical Manufacturing
On the production floor of agrochemical factories, raw materials need to tick a few boxes. They have to be stable, safe for storage, and reactive only when you want them to be. 3-Bromochlorobenzene fits because it doesn’t break down easily, but also reacts predictably. Agrochemical companies use it to lay the groundwork for pesticides, fungicides, and herbicides. The molecular structure makes it easy to add functional groups down the line, making it a favorite for chemical engineers—to stretch costs, improve yields, and meet new environmental rules.
Specialty Material Synthesis
In materials science circles, researchers keep a close eye on halogenated benzenes like this one. Some of the newer organic electronic materials need careful tailoring at the molecular level, where small tweaks can change a compound’s conductivity or light-emitting properties. 3-Bromochlorobenzene serves as a base for certain polymers and liquid crystals. My experience with development teams in display technology shows that getting the chemistry right early on makes a world of difference. That’s where this compound earns its reputation—bringing consistency and predictability for those pushing the limits in OLED screens and advanced sensors.
Tool for Cross-Coupling and Research
Long days in the lab introduce you to the Suzuki, Heck, and other cross-coupling reactions, staples in organic synthesis. 3-Bromochlorobenzene stands out as a choice substrate here: the bromine’s reactivity opens up avenues for attaching carbon-based partners, while the chlorine holds strong for more adjustments later. Synthetic chemists often pick it as a test case to prove a new catalyst works. Plenty of Ph.D. theses rest on experiments comparing different halogenated benzenes for yield, selectivity, and real-world results.
Considerations and Responsible Practice
The chemical merits of 3-Bromochlorobenzene bring real progress, but safety and the environment weigh on everyone’s mind. Its toxicity sits in the moderate range, so every lab following best practices keeps spills and exposure in check. Disposal teams handle halogenated waste with clear protocols—incineration in controlled facilities rather than down the drain. Forward-thinking companies put money into greener alternatives, but the versatility and availability of this building block mean it will stick around.
Paths Forward
The push toward sustainability creates pressure on chemical makers to rethink what “standard” means. Sourcing this compound from renewable feedstocks and finding catalysts that cut waste—both matter if the industry plans to shrink its environmental footprint. Sharing practical tips about handling, scaling reactions, and safe disposal helps everyone benefit from its unique chemistry, while keeping workers, communities, and ecosystems protected.
What It Is and Why It Matters
3-Bromochlorobenzene shows up in many organic synthesis labs. It’s a colorless to pale yellow liquid, and even though it looks innocent enough, chemists know looks drift far from reality with a halogenated aromatic compound. What folks handle in a fume hood can quietly cause irritation or something worse if caution gets skipped.
The Hazards in Plain Sight
Spend a few years working with halogenated benzenes and you start noticing you rarely hear people say, “That’s a benign solvent.” The material can irritate the skin, eyes, and respiratory system. It releases vapors that don’t give off a strong warning scent for most people, yet inhaling a bit too much after a spill or splash leaves you coughing or rubbing your eyes.
The International Agency for Research on Cancer pointed out that certain chlorinated and brominated benzenes raise long-term health concerns including carcinogenicity. It’s not a chemical anyone should treat casually in routine handling. How many times have people rinsed off gloves in the sink thinking it’s just a splash? You do that often enough and your skin will remind you it doesn’t like cold, chlorinated solvents.
Proper Handling–Not Just for Show
Wearing the right gear keeps the risk down. Splash goggles never win a fashion show, but they stop that stinging pain if something jumps up. Nitrile gloves shield your skin from cuts and accidental drips. Lab coats add a layer of trust, too. Keep food and drinks far from the bench, and always label bottles with clear handwriting—nobody wants to play the guessing game mid-experiment.
All chemical work needs good airflow. People describe fume hoods as noisy or stuffy, but they’re a wall between you and fumes you can’t smell coming. On busy days the temptation to take shortcuts grows, but a drop of 3-bromochlorobenzene on bare skin or in your eyes wipes away any time saved.
Spill and Exposure Action Steps
My early days in the lab came with one hard lesson: spills catch you off guard, even with the best habits. Absorb small spills with inert material—kitty litter or commercial absorbents in the building do the job. Seal the waste in a labeled container for pickup, don’t toss it in common trash. If skin or eyes take a hit, flush the area with running water for at least fifteen minutes and let your supervisor or health and safety team know what happened. It’s not about blame; it’s about preventing harm.
Waste Disposal and Environmental Responsibility
Organic halides don’t belong in drains. My old supervisor joked, “Once it’s down the sink, it doesn’t disappear; someone else just inherits the problem.” Waste management companies recycle or dispose of hazardous organics in a controlled way, which keeps these chemicals out of groundwater and out of reach of wildlife. The EPA tracks events where improper disposal leads to real environmental trouble, so it’s not just about following rules—it’s about protecting water and soil outside the lab.
Making a Safer Lab Culture
Safe handling only sticks if everyone buys in. The new grad students watch what more experienced researchers do, not what’s on the wall chart. More stories get swapped in the break room about near misses than heroic successful experiments. That culture of speaking up and supporting each other forms the backbone of real lab safety. Mistakes happen, and regular refreshers on the procedure catch a lot before they escalate.
Better Tools, Better Habits
I’ve seen labs upgrade fume hoods, swap in better gloves, and tweak training programs to deal with nasty compounds like 3-bromochlorobenzene. Universities and companies share incident reports now, and one group’s experience can become someone else’s new standard. A little more investment in simple containment and education cuts down on the number of accidents, and over time that leads to a safer research environment for everyone.
Breaking Down the Formula
3-Bromochlorobenzene holds a chemical formula of C6H4BrCl. Looking at its structure, it carries both a bromine and a chlorine atom attached to a benzene ring. The placement matters—it's in the “meta” position, which shapes the molecule's properties compared to its ortho or para isomers. This formula might look simple, but it’s got real muscle in research labs and industry.
Molecular Weight: More Than a Math Problem
The molecular weight clocks in at 207.45 grams per mole. I've weighed out plenty of chemicals, and accurate molecular weight shapes everything from safe handling to successful experiment results. The numbers come from simple math: carbon delivers 12.01, hydrogen gives 1.01, chlorine weighs in at 35.45, and bromine tips the scale at 79.90. Chemistry teachers stress these calculations because a tiny mix-up—grabbing the wrong isomer, estimating poorly—can throw off yields or contaminate products.
Why This Molecule Shows Up on Benches and in Talks
Researchers and product developers chase unique molecules that help them push into new territory. 3-Bromochlorobenzene often joins the party as an intermediate, driving reactions for pharmaceuticals, agrochemicals, or materials science. Only a few people outside the field think about these links even though they keep supply chains ticking along. If you use painkillers, clean with advanced solvents, or depend on technical coatings, you’ve probably benefited from processes that need this molecule or its cousins.
Safety and Handling Matter Every Day
I’ve worked in a few labs where safety depended on knowing what’s in the bottle. 3-Bromochlorobenzene earns respect because halogenated aromatics can irritate skin or lungs. Wearing gloves, goggles, and working in a hood cuts risk. That stuff isn’t just for the textbooks: one splash or careless whiff teaches a lesson faster than any safety poster. Chemical regulations in the US, Europe, and Asia require data on weight, formula, and effects so workers and communities stay informed.
Environmental and Health Considerations
Waste from brominated and chlorinated organics can linger longer in the environment than many people realize. In my experience, treating waste properly―with incineration or specialized disposal—can prevent trouble later. Ignoring it leads to contamination, sometimes showing up years after the fact. The importance of clear record-keeping and honest reporting can't be overstated, especially if everyone from bench scientist to environmental engineer wants to keep the land and water safe.
Raising Standards and Building on What Works
Using accurate formulas and weights for substances like 3-bromochlorobenzene keeps science honest. Investments in greener alternatives and better waste management reduce harm. Training and real-life drills make safety personal. Sharing experience, not just data, helps shift practices. Regulations tighten as industry learns from mistakes and keeps moving forward. The story behind 3-bromochlorobenzene is one of progress, calculation, and responsibility—measured one gram and one step at a time.
Keeping Chemicals Out of Trouble’s Way
Folks who’ve worked around organic chemicals know that little details matter. 3-Bromochlorobenzene, like a lot of aromatic compounds, shouldn’t be tossed on a corner shelf or poured down the drain. I’ve seen labs get careless, only to deal with hazardous fumes or ruined supplies down the line. Safely handling a chemical like this isn’t about being overly cautious—it’s about understanding what can go wrong and heading it off before it happens.
Proper Storage Keeps You and the Chemical Safe
If you’ve ever caught a whiff of halogenated benzenes in a closed room, you understand why good ventilation matters. Always stash 3-Bromochlorobenzene in a cool, dry spot out of sunlight. Direct sunlight and warm spaces speed up chemical reactions, which don’t do anyone any favors. Pick glass containers with tightly sealed caps. This isn’t just about keeping vapors inside; it’s about protecting the purity for whatever you plan to do next. A leaky lid invites moisture, dust, even insects—which can trigger reactions or wreck the chemical before you get to use it.
From experience, I’ve watched more than one colleague count on those cheap plastic containers, only to find cracked lids and sticky residue. Halogenated organics sometimes chew through polymers or seep out. Keep a chemical like this away from acids, bases, oxidizers, and anything flammable. I once saw someone store incompatible materials on the same shelf—cleanup wasn’t pretty. For household or teaching labs, a dedicated cabinet with spill containment helps if anything goes wrong. Put clear labels on every container and check them often. The extra five seconds could dodge hours of headaches later.
Disposal: Protecting People and the Planet
Disposing of chemicals isn’t just a legal hoop to jump through. Poured down a drain, 3-Bromochlorobenzene risks contaminating groundwater and damaging aquatic life. No quick fixes exist for organohalides in the wild. I remember helping a local wastewater treatment plant analyze pollutants—these compounds just don’t break down quickly and cause real headaches down the line.
Best practice means collecting unwanted or used material in a labeled, sealed container. Don’t mix it with random leftovers since that can produce unknown, possibly toxic compounds. Most cities with universities or modern hospitals have chemical waste programs or contract with companies for pick-up services. Even small amounts are worth turning in—laws and protocols now require documentation, so there’s more pressure not to cut corners.
Incineration under tightly controlled conditions, using specialized equipment, stands out as the safest destruction method. Temperatures reach high enough to crack the molecule and prevent the emission of toxic byproducts. Back in a university lab, I worked alongside environmental safety staff who stressed how landfilling or burning unregulated waste spread toxins farther than laypeople expected. Taking waste to authorized disposal channels protects workers, the public, and local wildlife.
Choosing Safer Paths: Training and Accountability
Training for staff and students makes a difference. I’ve run safety sessions that shifted old habits and encouraged folks to pause before dumping or storing a bottle the easy way. Updates to storage charts and hazard sheets, with visual reminders, help keep standards high. Good records—batch numbers, dates, user logs—also catch mistakes before they grow.
In research circles, there’s a trend toward replacing persistent pollutants with greener substitutes. Teaching anyone who will work with aromatic compounds to check safety data and waste protocols builds habits that last. At the core, careful storage and disposal of 3-Bromochlorobenzene reflects a broader respect for one’s colleagues and community. Each step upholds ethics and protects people who may never set foot in the lab.
| Names | |
| Preferred IUPAC name | 1-Bromo-3-chlorobenzene |
| Other names |
m-Bromochlorobenzene
1-Bromo-3-chlorobenzene 3-Chlorobromobenzene m-Chlorobromobenzene |
| Pronunciation | /ˌθriːˌbroʊ.moʊˈklɔː.rəˌbɛn.ziːn/ |
| Identifiers | |
| CAS Number | 108-37-2 |
| Beilstein Reference | 1209230 |
| ChEBI | CHEBI:138167 |
| ChEMBL | CHEMBL36362 |
| ChemSpider | 88206 |
| DrugBank | DB08326 |
| ECHA InfoCard | 200-208-7 |
| Gmelin Reference | 162379 |
| KEGG | C01585 |
| MeSH | D017927 |
| PubChem CID | 69669 |
| RTECS number | CY8575000 |
| UNII | 9G8T84S1Q9 |
| UN number | UN2686 |
| CompTox Dashboard (EPA) | DTXSID8045177 |
| Properties | |
| Chemical formula | C6H4BrCl |
| Molar mass | 206.45 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Odor | Aromatic odor |
| Density | 1.615 g/mL at 25 °C (lit.) |
| Solubility in water | Insoluble |
| log P | 3.97 |
| Vapor pressure | 0.46 mmHg (25 °C) |
| Acidity (pKa) | 25.8 |
| Basicity (pKb) | 3.84 |
| Magnetic susceptibility (χ) | -79.0×10⁻⁶ cm³/mol |
| Refractive index (nD) | 1.563 |
| Viscosity | 1.179 mPa·s (25°C) |
| Dipole moment | 2.60 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 266.7 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | 36.6 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -3632 kJ mol⁻¹ |
| Hazards | |
| GHS labelling | GHS02, GHS07 |
| Pictograms | GHS07 |
| Signal word | Warning |
| Hazard statements | H302, H315, H319, H335 |
| Precautionary statements | P261, P264, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P332+P313, P337+P313, P362+P364, P501 |
| Flash point | 77 °C (closed cup) |
| Autoignition temperature | 566°C |
| LD50 (median dose) | LD50 (median dose): >5000 mg/kg (rat, oral) |
| NIOSH | CN8570000 |
| PEL (Permissible) | Not established |
| REL (Recommended) | 0.1 ppm |
| IDLH (Immediate danger) | Not established |
| Related compounds | |
| Related compounds |
1-Bromo-3-chlorobenzene
1-Chloro-3-bromobenzene 3-Bromo-4-chlorobenzene 3-Chlorobromobenzene 1,3-Dibromobenzene 1,3-Dichlorobenzene Bromobenzene Chlorobenzene |
