Material Safety Data Sheet: 2-Bromopropane

Identification

Product Name: 2-Bromopropane
Other Names: Isopropyl bromide
Chemical Formula: C3H7Br
CAS Number: 75-26-3
Recommended Use: Laboratory reagent, intermediate for organic synthesis
Supplier: Contact chemical provider directly
Emergency Phone: Refer to local emergency number or poison control

Hazard Identification

Classification: Flammable liquid, acute toxicity (oral, inhalation, dermal), specific target organ toxicity (single exposure)
Signal Word: Danger
Hazard Statements: Causes skin irritation, serious eye irritation, may cause respiratory irritation, harmful if swallowed, suspected of damaging fertility or the unborn child, flammable liquid and vapor
Pictograms: Flame, exclamation mark, health hazard
Precautionary Statements: Avoid breathing vapors or mist, keep away from heat/sparks/open flame, wear protective gloves and eye protection, use only outdoors or in well-ventilated areas

Composition / Information on Ingredients

Chemical Name: 2-Bromopropane
Common Synonyms: Isopropyl bromide
Purity: 98–100%
Impurities: May contain trace halide or hydrocarbon residues depending on source
Molecular Weight: 123 g/mol

First Aid Measures

Inhalation: Move to fresh air, monitor breathing, administer oxygen if necessary, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash skin with soap and water for at least 15 minutes, seek medical advice if irritation develops
Eye Contact: Rinse eyes cautiously with water for at least 15 minutes, remove contact lenses if present and easy to do, continue rinsing, get medical help
Ingestion: Rinse mouth thoroughly, do not induce vomiting, never give anything by mouth to an unconscious person, consult a physician immediately
Symptoms: Coughing, shortness of breath, headache, dizziness, skin irritation, red or watery eyes

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, alcohol-resistant foam
Unsuitable Extinguishing Media: Direct water jet may spread fire
Specific Hazards: Vapors can form explosive mixtures with air, thermal decomposition can release toxic fumes such as hydrogen bromide and carbon oxides
Protective Equipment: Use self-contained breathing apparatus, full protective clothing required
Special Procedures: Approach from upwind, use water spray to cool fire-exposed containers, prevent run-off contamination

Accidental Release Measures

Personal Precautions: Evacuate area, ventilate space, avoid inhalation of vapor, wear protective gloves, boots, and chemical splash goggles
Environmental Precautions: Prevent from entering drains, sewers, or waterways
Methods for Cleanup: Absorb with inert material (sand, vermiculite), place in closed chemical waste containers, flush area with water after clean-up, dispose of according to regulations
Reporting: Notify local health, safety, and environmental authorities if release poses significant risk

Handling and Storage

Handling: Work in chemical fume hood, minimize contact with skin and eyes, wear protective equipment, avoid breathing dust or vapors, wash thoroughly after handling, do not eat or drink during use
Storage: Store in tightly closed original container, keep in cool, dry, well-ventilated place away from incompatible substances and sources of ignition, store under nitrogen if possible to prevent degradation
Incompatibles: Strong oxidizers, strong bases, sodium, potassium, alkali metals

Exposure Controls and Personal Protection

Exposure Limits: No established occupational exposure limits in many jurisdictions; consult local regulations
Engineering Controls: Use in a certified chemical fume hood, maintain adequate ventilation
Personal Protection: Nitrile gloves, chemical splash goggles, flame-resistant laboratory coat, use of respirators for poorly ventilated areas, emergency eye wash and safety shower accessible

Physical and Chemical Properties

Appearance: Colorless liquid
Odor: Characteristic sweet, ether-like
Odor Threshold: Not determined
pH: Not applicable
Melting Point: -120°C
Boiling Point: 59–60°C
Flash Point: 2°C (closed cup)
Evaporation Rate: Not available
Flammability: Flammable liquid
Upper/Lower Flammable Limit: UEL: 10.7% LEL: 3.3% (estimated)
Vapor Pressure: 200 mmHg at 20°C
Vapor Density: 4.2 (air = 1)
Relative Density: 1.310 g/cm³ at 20°C
Solubility: Slightly soluble in water, soluble in most organic solvents
Partition Coefficient (n-octanol/water): 2.1
Auto-Ignition Temperature: Approx. 460°C
Decomposition Temperature: Not available
Viscosity: Not determined

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Possibility of Hazardous Reactions: May react with strong bases or strong oxidizers, risk of fires or explosions with incompatible substances
Conditions to Avoid: Heat, flames, sparks, static discharge, exposure to strong sunlight
Decomposition Products: Hydrogen bromide, carbon monoxide, carbon dioxide
Polymerization: Not known to occur

Toxicological Information

Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: LD50 (oral, rat): 1800 mg/kg; LD50 (dermal, rabbit): >2000 mg/kg
Chronic Effects: May cause effects on the blood, bone marrow, and nervous system from repeated or prolonged exposure
Carcinogenicity: Not classified as carcinogenic by IARC or NTP, but limited evidence of reproductive toxicity (some studies link to impaired fertility and developmental toxicity)
Other Hazards: High vapor concentrations may cause narcosis, headache, dizziness, central nervous system depression
Symptoms of Overexposure: Drowsiness, weakness, numbness, skin reddening, eye redness and tearing, respiratory irritation

Ecological Information

Ecotoxicity: Harmful to aquatic life, low to moderate persistence in environment
Persistence and Degradability: Not readily biodegradable, may undergo slow hydrolysis in water
Bioaccumulative Potential: Potential for bioaccumulation moderate (Log Kow approx. 2.1)
Mobility in Soil: Moderate mobility based on vapor pressure and water solubility—can volatilize from soil or water surfaces
Other Adverse Effects: Data for long-term environmental consequences limited; avoid release to environment

Disposal Considerations

Waste Disposal Methods: Collect in suitable containers, label and dispose of through licensed chemical waste contractors, do not pour into sewers, regular trash, or water sources
Contaminated Packaging: Dispose of as hazardous waste, ensure containers are thoroughly cleaned before recycling or discard
Regulatory Disposal Requirements: Comply with local, regional, and national regulations regarding chemical waste

Transport Information

UN Number: UN2344
UN Proper Shipping Name: 2-Bromopropane
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: II
Environmental Hazards: Not a marine pollutant according to current DOT/IMDG classifications
Special Precautions: Keep containers upright and tightly sealed during transport, label correctly with flammable liquid warnings, keep away from sparks and open flames

Regulatory Information

US TSCA: Listed
OSHA Hazard Communication: Classified hazardous
SARA Title III: Not on Extremely Hazardous Substances list; spill reporting may be required
EPA CERCLA: Not listed for mandatory reportable quantities
Canada DSL/NDSL: Listed
WHMIS Classification: B2 (Flammable liquid), D2B (Toxic material causing other effects)
ECHA (EU) Status: Registered under REACH
Other Regulations: Comply with all applicable workplace safety, chemical storage, transportation, and environmental protection laws