Material Safety Data Sheet – 2-Bromobutyric Acid

Identification

Product Name: 2-Bromobutyric Acid
SYNONYMS: α-Bromobutyric acid
Chemical Formula: C4H7BrO2
CAS Number: 80-58-0
Molecular Weight: 167.00 g/mol
Recommended Use: Laboratory chemicals, intermediates, chemical research
Supplier: Name, address, phone number, and emergency contact of manufacturer or distributor

Hazard Identification

GHS Classification: Acute Toxicity (Oral): Category 4; Skin Corrosion/Irritation: Category 2; Serious Eye Damage/Irritation: Category 2A; Specific Target Organ Toxicity - Single Exposure: Category 3
Signal Word: Warning
Hazard Statements: Harmful if swallowed; Causes skin irritation; Causes serious eye irritation; May cause respiratory irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid contact with skin, eyes, clothing; Avoid inhalation of vapors or dust; Use in a well-ventilated area; Wash thoroughly after handling; Wear protective gloves, goggles, and clothing

Composition / Information on Ingredients

Substance: 2-Bromobutyric Acid
PURITY: ≥98%
Chemical Identity: C4H7BrO2
CAS Number: 80-58-0
Impurities and Stabilizers: May contain trace organic impurities, not considered significant for classification

First Aid Measures

Inhalation: Remove person to fresh air, keep comfortable for breathing, seek medical attention if breathing becomes difficult
Skin Contact: Immediately wash skin with plenty of water and soap, remove contaminated clothing, get medical advice if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy, continue rinsing, seek medical assistance if symptoms persist
Ingestion: Rinse mouth with water, call poison control or physician, do not induce vomiting unless instructed by medical personnel
Symptoms and Effects: Burning sensation on skin and mucous membranes, coughing, headache, possible nausea

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam
Unsuitable Media: Avoid high-pressure water streams
Specific Hazards from Fire: Thermal decomposition can generate hydrogen bromide, carbon oxides, and corrosive fumes
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing
Special Procedures: Stay upwind, prevent runoff into drains, use water spray to cool exposed containers

Accidental Release Measures

Personal Precautions: Evacuate area, provide adequate ventilation, avoid breathing dust or vapor, wear protective equipment
Environmental Precautions: Prevent spill from entering drains, watercourses, or soil
Methods for Cleanup: Absorb spill with inert material such as sand or vermiculite, place in chemical waste container for disposal, wash spill area thoroughly with water
Decontamination: Clean equipment and floors after spill

Handling and Storage

Handling: Use in chemical fume hood, avoid contact with skin, eyes, and clothing, keep away from heat and open flames, avoid inhaling vapors
Storage: Store in tightly closed containers, in a cool, dry, and well-ventilated area away from incompatible substances such as strong bases and oxidizing agents, label containers properly
Other Precautions: Ensure proper grounding when transferring material, segregate from food and feedstuffs

Exposure Controls and Personal Protection

Occupational Exposure Limits: No specific OSHA/ACGIH exposure limits established for this chemical; use workplace guidelines for general nuisance dust or vapor
Engineering Controls: Use chemical fume hood, ensure eyewash stations and safety showers available, maintain good ventilation
Personal Protective Equipment: Wear chemical-resistant gloves (nitrile or neoprene), safety goggles or face shield, lab coat or protective clothing, suitable respiratory protection if exposure limits are exceeded or in case of inadequate ventilation
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing before leaving workplace

Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid
Odor: Pungent, acidic
Boiling Point: Approximately 205°C
Melting Point: -8°C
Flash Point: 101°C (closed cup)
Density: 1.55 g/cm³
pH: Not diluted: strongly acidic
Solubility: Soluble in water, ethanol, organic solvents
Vapor Pressure: Low at ambient temperature
Partition Coefficient: Log Kow: estimated at 1.5
Viscosity: Not determined

Stability and Reactivity

Chemical Stability: Stable at room temperature under normal conditions
Conditions to Avoid: Excessive heat, open flames, sources of ignition, direct sunlight
Incompatible Materials: Strong oxidizing agents, strong bases, amines
Hazardous Decomposition Products: Hydrogen bromide, carbon oxides, corrosive fumes
Hazardous Polymerization: Does not occur under normal storage and handling

Toxicological Information

Likely Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral LD50 (rat): reported as 1880 mg/kg; may cause harmful effects if swallowed; inhalation can irritate respiratory tract
Skin Corrosion/Irritation: Causes skin irritation, redness, and discomfort
Serious Eye Damage/Irritation: Causes eye irritation, pain, and redness
Respiratory Effects: May cause coughing, sore throat, or shortness of breath
Chronic Effects: Prolonged or repeated exposure can cause skin sensitivity or dermatitis
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Other Data: No specific reproductive or mutagenic effects noted in available studies

Ecological Information

Aquatic Toxicity: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment; avoid discharge into environment
Persistence and Degradability: Not readily biodegradable in natural settings
Bioaccumulation Potential: Moderate, based on partition coefficient
Mobility in Soil: Expected to move through soil and reach groundwater if released
Other Adverse Effects: No data for ozone depletion or global warming

Disposal Considerations

Waste Disposal Methods: Dispose of in accordance with local, regional, and national regulations as hazardous chemical waste; do not dispose of in household garbage or by pouring down the drain
Preferred Treatment: Incinerate in properly equipped chemical incinerator with afterburner and scrubber, or consult licensed waste disposal company
Contaminated Packaging: Dispose of empty containers as hazardous waste, ensure all residues are removed before disposal

Transport Information

UN Number: 3265
UN Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (contains 2-Bromobutyric Acid)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: III
DOT, IMDG, IATA: Regulated for transportation as a hazardous substance
Environmental Hazards: May present a risk to the aquatic environment
Special Precautions: Protect containers from physical damage, keep upright, use approved packaging

Regulatory Information

US Regulations: TSCA listed; not subject to SARA Title III reporting; follow OSHA regulations for hazardous chemical handling
EU Regulations: Classified as hazardous under Regulation (EC) No 1272/2008 (CLP); listed in EINECS
Label Elements: GHS hazard pictograms, signal words, hazard and precautionary statements required
Other International Regulations: Consult local and national regulatory bodies for additional compliance requirements