1-Bromohexadecane: An In-Depth Look at a Niche Alkyl Halide

Historical Development

Chemists started exploring long-chain alkyl bromides such as 1-Bromohexadecane in the late 1800s. Synthetic organic chemistry pushed research forward, not just for academic curiosity, but out of practical needs in surfactants and specialty lubricants as industry boomed. Petrochemical technology made these compounds easier to produce with fewer impurities and higher yields. Over time, researchers in both public and private labs began to recognize the value of controlled halogenation, and 1-Bromohexadecane found its niche on the shelves of chemical suppliers. Its straightforward structure—one bromine atom attached to a straight sixteen-carbon chain—made it a favorite for reaction studies and customized chemical syntheses, especially where pure, reproducible substrates made or broke a project’s success.

Product Overview

1-Bromohexadecane, also called cetyl bromide, looks like a colorless to pale yellow oily liquid at room temperature. Many refer to it as a specialty intermediate used mainly in laboratory settings or niche industrial processes. Unlike short-chain bromides, 1-Bromohexadecane’s long hydrocarbon tail gives it valuable surfactant-likeness and makes it more insoluble in water. In practical labs, bottles come with clear hazard labels, a Certificate of Analysis, and batch traceability. Researchers reach for this chemical to build more complex molecules, tailor polymers, or modify biological surfaces, where the controlled presence of a single bromine atom at the end of a long chain makes a difference in downstream reactions.

Physical & Chemical Properties

1-Bromohexadecane has a molecular formula of C16H33Br and a molar mass of about 305.34 g/mol. It comes with a melting point near 15°C and boils in the 344–348°C range. Immiscibility in water stands out, and it exhibits high solubility in organic solvents like ether and chloroform. The presence of the bromine at the terminal carbon creates a reactive site primed for substitution or elimination, unlike the inert hexadecane backbone. The compound’s density surpasses water, fitting for a bromine-containing molecule, with a faint but distinctive odor that lingers on lab benches familiar with halogenated compounds.

Technical Specifications & Labeling

Suppliers ship 1-Bromohexadecane with product purity often above 98%, validated by techniques such as gas chromatography, NMR, and sometimes IR spectroscopy. Bottles must carry hazard statements about skin, respiratory, and environmental risks, consistent with global standards like GHS. Clear chemical identification—name, CAS number 112-82-3—and batch numbers appear on each label. Labs expect safety data sheets listing boiling point, melting point, storage instructions, and first-aid protocols. Reliable suppliers conduct quality checks to ensure color, refractive index, and absence of residual solvents meet regulatory standards, allowing chemists to focus on their work without second-guessing what’s inside the bottle.

Preparation Method

1-Bromohexadecane synthesis begins with hexadecanol or hexadecane. A common lab route reacts hexadecanol with hydrobromic acid, sometimes catalyzed by phosphorus tribromide, which replaces the terminal hydroxyl group with a bromine atom. In larger-scale settings, direct halogenation of hexadecane using bromine under UV light offers a more robust pathway, but often at the expense of side products and the need for careful purification. Experienced chemists can push the reaction towards the terminal position with controlled temperature and light exposure, followed by distillation or column chromatography to isolate pure 1-Bromohexadecane. Taking time here pays off; even small amounts of dibromides or unreacted starting material can ruin future syntheses.

Chemical Reactions & Modifications

With a bromine atom fixed on the end, 1-Bromohexadecane reacts predictably with nucleophiles in an SN2 fashion. Simple tests involve converting it to hexadecyl amines with ammonia, or making ethers using alkoxides. Researchers use it as an alkylating agent to add long hydrophobic chains to molecules—great for making cationic surfactants, quaternary ammonium salts, and certain polymers. Grignard formation, where magnesium inserts itself to create hexadecylmagnesium bromide, opens the doors to couplings and carbon–carbon bond formation. Organic chemists appreciate how clean and controlled these reactions go with a pure batch—the kind of reliability that keeps projects moving forward.

Synonyms & Product Names

1-Bromohexadecane gets called by many names—cetyl bromide, n-hexadecyl bromide, or bromocetane crop up in product catalogs and scientific articles. Its CAS number, 112-82-3, stays consistent worldwide. Whether a researcher in Shanghai, a manufacturer in Houston, or an environmental toxicologist in Berlin, these alternative names avoid confusion when ordering, identifying, or searching for this key intermediate in chemical databases and regulatory documents.

Safety & Operational Standards

This compound carries clear health and safety risks. Skin contact can cause irritation or dermatitis. Fumes and mists, especially in enclosed spaces, may irritate the lungs. Personal experience reminds anyone who’s careless—pure alkyl bromides stain skin and leave a burning sensation. Standard lab safety means nitrile gloves, goggles, and a fume hood. Companies comply with OSHA, REACH, and GHS standards, which treat 1-Bromohexadecane as a hazardous substance and demand strict secondary containment, spill protocols, and waste disposal procedures. The bromine atom not only gives chemical reactivity, it also adds an extra dimension to safety, as breakdown in the environment leads to persistent organobromine species.

Application Area

The main use of 1-Bromohexadecane comes in chemical synthesis. Surfactant manufacturers rely on this compound for quaternary ammonium salts used in fabric softeners, disinfectants, and hair conditioners. In research circles, chemists use it to modify lipids and create model membranes. It finds service in lubricants, specialty coatings, and antistatic agents—industries that value strong hydrophobic properties and custom molecular architecture. Recent years brought a push in materials science, where functionalization of nanoparticles often starts with alkyl halides of just this type, turning inert surfaces into platforms for sensors, drug delivery, or advanced electronics. This pipeline from starting material to product shapes whole industries from textiles to electronics.

Research & Development

1-Bromohexadecane became a familiar tool in the organic and materials labs I’ve known, both in university training and in industry-scale process development. Publications from the last two decades show a steady stream of modifications, where longer or shorter alkyl chains gave new physical characteristics to surfactants or polymers. One growing area draws on its ability to attach flexible, hydrophobic chains to nanoparticles or biological molecules, advancing responsive materials for next-generation sensors. Green chemistry researchers look for less toxic bromination agents and milder conditions, slicing waste, and improving atom efficiency. This R&D emphasizes both ecological responsibility and the need for precision in building stepwise molecular architectures.

Toxicity Research

Work with alkyl bromides demands respect, as early toxicity studies flagged problems with skin, eye, and respiratory irritation. Occupational exposure limits stay strict, and newer research highlights not just acute, but also long-term ecological harm from persistent brominated compounds. Animal studies indicate bioaccumulation and potential neurotoxicity from proactive or poorly contained industrial spills. Environmental toxicologists now watch for brominated breakdown products in water tables, sounding the alarm when regulations lag behind science. Improved analytical detection helps track trace levels but doesn’t remove the burden from users to handle and dispose according to best practices.

Future Prospects

People in chemical and materials industries recognize the versatility 1-Bromohexadecane brings, but growing regulatory and market pressures push innovation. As environmental and occupational health regulations get tighter, companies invest in more sustainable production methods, cleaner brominating agents, and better waste stewardship. Researchers worldwide explore using this compound in green surfactant formulations, advanced drug-delivery vectors, and biodegradable polymer designs. The push for sustainable chemistry doesn’t erase the demand for tailored intermediates; it changes the way we think about sourcing, reacting, handling, and remediating. The future for 1-Bromohexadecane rides on new methods that protect both worker and environment without sacrificing the elegance of organic synthesis or the performance of consumer products built from it.



What is 1-Bromohexadecane used for?

Down-to-Earth Chemistry: Why 1-Bromohexadecane Matters

Every industry depends on a steady flow of raw materials to keep processes moving. One of those materials, 1-Bromohexadecane, flies under most people’s radar, but it helps drive several essential chemical reactions that touch our lives in more ways than you’d expect.

What Makes This Chemical Unique?

Let’s get real—1-Bromohexadecane isn't going to show up in your medicine cabinet or on a grocery store shelf. What it does brings an important versatility to the table, especially for those working in organic synthesis. Over the years, chemists have found that its long, 16-carbon chain combined with a single reactive bromine atom offers a strong building block. When making more advanced molecules, that reactivity comes in handy. The compound serves as an alkylating agent, which basically means it helps add a chunk of carbon atoms to other molecules. Without building blocks like this, a lot of specialty compounds would get stuck at square one.

Role in Making Surfactants and Quaternary Ammonium Compounds

During my years working in the chemical industry, I saw the value puzzles like 1-Bromohexadecane solve. In production, it’s often used to make surfactants. These are the compounds that let water mix with oil, like in soaps, shampoos, and detergents. To get just the right kind of surfactant, manufacturers modify long-chain molecules. They look for substances that can interact with both water and grease. 1-Bromohexadecane lets them build molecules that do exactly that.

Some chemists use it to create quaternary ammonium compounds, which pop up in disinfectants and personal care items. These “quats” deliver antimicrobial properties and help keep surfaces and skin clean. That’s no small feat in a world where clean spaces keep us safe.

Applications in Research and Materials Science

Beyond industry, research labs use 1-Bromohexadecane to anchor specific groups on test surfaces, helping to study everything from advanced coatings to the behavior of new materials. In nanotechnology, controlling the surface of a metal particle with a chain like this can create smart materials. This kind of work lays the foundation for things like improved batteries and medical sensors. Getting those breakthroughs takes consistency and purity, and that’s where experience counts: knowing how to handle and source such specialty chemicals safely and reliably, because one impurity can throw off months of work.

Keeping Safety in the Picture

Many people forget about the other side of specialty chemicals—the safety risks and environmental impact. 1-Bromohexadecane isn’t found naturally; it’s produced through chemical reactions that need control and oversight. Production teams use personal protective gear and proper ventilation to manage exposures. Chemical waste must be handled responsibly. I’ve seen companies that invest in disposal systems fare far better in the long run, both for worker health and compliance.

Challenges and Smarter Solutions

Oversight and training sit at the core of good chemical handling. Producers look for greener synthesis paths and ways to reuse byproducts. Switching to less hazardous ingredients or recycling leftover material cuts down on waste. Open data sharing between research groups and companies can spark safer, more efficient manufacturing too. I’ve met chemists who routinely push for peer-review and audits, which helps boost both public confidence and process safety.

So, one molecule like 1-Bromohexadecane might not make headlines, but its fingerprints show up in research labs, on factory floors, and even in the products people use each day. Paying attention to safety, sustainability, and responsible sourcing is as important as the science behind it.

What is the molecular formula and molecular weight of 1-Bromohexadecane?

The Chemistry at a Glance

Lots of people in chemistry circles get excited about simple organic molecules, and for good reason. Practical uses and research both get a boost when people know what goes into a compound right down to the last atom. This gives a real-world edge—especially for teachers, chemical engineers, regulatory analysts, and folks who brew up compounds in the lab.

Breaking Down the Formula of 1-Bromohexadecane

This compound packs a decent punch with a structure straight out of the organic chemistry playbook. 1-Bromohexadecane starts life as a hydrocarbon—hexadecane—then swaps one hydrogen atom for a bromine. No surprises in the name: “hexadecane” tells you there are 16 carbon atoms chained up in a row, and “1-bromo” means the bromine claims the very first carbon.

Adding it up, the full molecular formula clocks in as C16H33Br. Here’s the math: Hexadecane all by itself is C16H34. Bromine bumps out one hydrogen, so subtract one hydrogen and add a bromine atom.

Why the Numbers Add Up: Calculating Molecular Weight

I’m the type who likes putting puzzles together, and atomic weights form the puzzle pieces in these cases. Want to figure out actual grams or amounts for a reaction? You absolutely need this number. The atomic weights (rounded for easy use): carbon 12.01, hydrogen 1.008, bromine 79.90.

Laying it all out:

  • 16 carbons: 16 x 12.01 = 192.16
  • 33 hydrogens: 33 x 1.008 = 33.26
  • 1 bromine: 1 x 79.90 = 79.90

Sum these up: 192.16 + 33.26 + 79.90 gives 305.32 g/mol.

Trust, Traceability, and Research Safety

Whether it’s an undergraduate chemistry class or a pharmaceutical lab, knowing chemical identity and weight matters a lot. Imagine tallying out chemicals for a reaction only to trigger a failed run or worse, a runaway reaction due to wrong measurements. Proper formulas and weights keep experiments on track and chemicals traceable. Reputable databases and lab procedures rely on this kind of accuracy to keep users safe—and honest. The formula and molecular weight also help emergency responders and medical staff evaluate hazards in case of accidents.

Stepping Up Quality—Preventing Costly Mistakes

In my own work, getting the molecular formula wrong once led to an order for the wrong variant of a compound—a simple oversight but the kind that can cost thousands in wasted time and material. Small errors like this rapidly multiply at scale, and the ripple effect reaches biotech, agriculture, and manufacturing. Most quality procedures and documentation revolve around clear chemical identity to nip problems in the bud. Simple diligence like confirming a formula or weight often spares a world of headache down the line.

Practical Solutions: Resources and Checking Work

Whether in research or industry, using trusted databases (like ChemSpider, PubChem, or Merck Index) helps verify details for compounds like 1-Bromohexadecane. Having a habit of writing out the structure and double-checking atom counts might seem old-school, but it pays off. Teaching young scientists to work with tangible numbers early, rather than skipping to a quick internet lookup, builds skills that last.

Some safety data sheets and chemical suppliers also print formula and weight on their labels—never hurts to look. Training and checklists in university labs or company settings keep errors at bay. Newer software tools are handy, but real expertise forms when people combine automation with hands-on experience.

How should 1-Bromohexadecane be stored?

Looking Out for Health and Safety

I remember working in a small academic lab where every chemical seemed harmless on paper, and yet the strongest memories I have come from events no one expected—little splashes, leaking containers, almost-missed labels. 1-Bromohexadecane is no exception. This chemical might appear manageable, but those handling it know better than to cut corners. Its oily, colorless form can mask real hazards. Prolonged skin contact or inhalation puts people at risk of irritation or worse, so chemistry demands a little respect, and storage shapes that respect daily.

Keeping It Contained

For starters, a tightly sealed glass container works best. Plastic sometimes reacts with certain organobromine compounds if left unchecked, and any loose-fitting lids invite vapors that linger for hours. At room temperature, you want the substance away from sunlight and heat, not just because of decomposition, but also because those energy sources push up the chances of pressure buildup or accidental spillage. A clean, dry atmosphere does the rest, and standing up to these principles is about community as much as personal safety.

Labeling Builds Trust

One grim reality faced by older labs: lost or faded labels turn every container into a wild guessing game. 1-Bromohexadecane deserves a bright, legible label showing its full name, stock number, emergency codes, and date opened. It may seem obvious, but plenty of accidents trace back to shortcuts on labeling. You want a system that lets any team member—new or seasoned—figure out what’s in front of them at a glance. Knowledge is the best defense against confusion.

Thinking About the Bigger Picture

Proper storage means more than just fire safety. 1-Bromohexadecane shouldn't sit alongside acids, oxidizers, or strong bases. Reactions between these classes can release irritants or toxic fumes, and that's a risk nobody needs inside a workspace. Chemical compatibility charts exist for good reasons. Following them reduces headaches and helps the community avoid close calls.

Ventilation Matters

On a muggy summer afternoon, I once watched a student open a poorly stored halide. No fume hood, just a simple bench, and within minutes, the room caught a whiff of something sharp. This isn’t a rare scene. Proper storage relies on good ventilation. If the main cabinet doesn’t vent well, fumes may build up—not a headline anyone wants. Modern storage cabinets with exhaust systems keep the air clear, everyone breathing easy.

Regular Checks and a Culture of Care

Storage practices only work if people make time to check in. Inventory reviews every few months build habits and help spot issues before they turn urgent. Outdated or compromised bottles can be flagged and dealt with before trouble starts. The people in the lab—students, techs, postdocs—carry the well-being of everyone on their shoulders by setting an example.

Building Solutions Together

Mistakes happen. A culture that welcomes honest reporting, routine discussions about safety, and real training sessions empowers everyone in the lab. I’ve seen teams thrive when each member’s voice is valued about storage and safety. If budgets allow, investing in lockable cabinets, updated signage, and personal protective equipment turns responsible storage into a habit, not a burden.

Why Discipline Always Wins

Storing 1-Bromohexadecane correctly isn’t about avoiding punishment or meeting some abstract rule set by an authority. It’s about protecting friends, classmates, and colleagues. It’s about shaping a workplace where nobody stays up at night worrying about what they’ve left behind. Take the time. Teach the steps. Check those containers. That’s where trust begins.

Is 1-Bromohexadecane hazardous or toxic?

What is 1-Bromohexadecane?

1-Bromohexadecane shows up in chemistry labs as a long-chain alkyl bromide—essential for research and sometimes for specialty manufacturing. Some surfactants, lubricants, and specialty chemicals start with compounds just like it. People outside lab walls rarely notice it, but that doesn’t mean it’s just another safe household product.

Potential Hazards and Toxicity

Companies and safety sheets label 1-bromohexadecane as harmful on skin contact or if inhaled. My own time spent handling similar brominated organics taught me to respect these warnings. Direct skin contact often causes irritation. Without gloves, even small splashes brought on red, itchy skin for people nearby. Extended exposure ramps up the risks. Eyes sting if fumes or tiny droplets get loose.

Information from the European Chemicals Agency places alkyl bromides in a category worth treating with care. The bromine is reactive, which means it can affect cell membranes or even disrupt enzymes. Chemicals like this have turned up in environmental studies because they don’t break down quickly in nature. Wildlife might end up exposed as these compounds leach through water and soil.

Data about 1-bromohexadecane’s long-term toxicity in people is slim, so scientists study chemical cousins for clues. Lab workers have reported headaches, dizziness, and coughing after breathing low levels of related bromides without good ventilation. Some animal studies suggest organ damage after chronic exposure, particularly for the liver and kidneys.

Industry Practices and Employee Safety

Spending many hours in chemical plants and academic facilities, I’ve seen how policy changes make a difference. Modern lab safety practices now mandate splash goggles, proper gloves, and fume hoods for anyone handling alkyl bromides. Even spill response kits come loaded with materials that neutralize organobromines quickly. Regular safety briefings help staff learn how to store these chemicals in tight-sealed bottles far from heat, sunlight, acids, or open flames.

Accidental spills force an evacuation and thorough cleanup. Rapid containment keeps fumes down, and chemical absorbents prevent runoff from hitting the water supply. Local fire departments take these incidents seriously, often bringing meters to check air quality and confirm rooms are safe before people go back inside.

Environmental and Waste Considerations

Waste management teams recognize that 1-bromohexadecane doesn’t disappear in landfills. Most labs send waste streams with brominated organics to special incinerators designed to break them down at very high temperatures. Municipal water systems lack the tools to filter out traces of these chemicals, so strict protocols keep them out of sinks and drains.

Learning from chemical families, environmentalists now call for safer substitutes when possible. Chemical engineers experiment with greener alternatives so factories and labs reduce their reliance on bromines with potential long-term effects on people and the planet.

How to Move Toward Safer Handling

Clear labeling, training, and responsible disposal stand out as basic steps that boost safety. Workers trained to recognize danger signs act quickly, preventing what once could have become a serious accident. Keeping detailed records helps identify patterns, allowing teams to improve processes or find safer options. Companies choosing less hazardous alternatives set a new standard for safety and environmental stewardship.

What are the physical properties of 1-Bromohexadecane (appearance, boiling point, etc.)?

What 1-Bromohexadecane Looks Like

1-Bromohexadecane catches the eye with its clear, oily liquid form. No flakes, no powders—just a transparent substance, sometimes tinged with a pale yellow hue if it picks up a bit of impurity or ages on the shelf. When you pour it from one flask to another, it moves slowly, its viscosity coming from those 16 carbon atoms stacked up in its long hydrocarbon tail.

Boiling and Melting Points

Life in the lab isn’t always about telescopes and glittering crystals. Sometimes you get stuck watching a thermometer climb. With 1-Bromohexadecane, patience is a friend. The boiling point hovers around 343°C (about 649°F). That’s not something you see bubbling away in a tea kettle; it sits firmly among high-boiling organic liquids. If you ever cold-store it and crank the freezer way down, expect it to freeze close to -2°C (around 28°F), turning from slick liquid into a waxy solid block.

Density and Solubility

You probably won’t be drinking this stuff, but density talks matter for chemists and engineers. 1-Bromohexadecane’s density sits around 0.86 to 0.87 grams per cubic centimeter at room temperature. Less dense than water, so if dropped into a beaker, it tends to float on top. Water and this compound don’t get along—no blending together, not even a little bit. Its hydrophobic nature means it stubbornly repels water, yet dissolves easily in organic solvents like chloroform, ether, or hexane. This behavior links back to its long carbon chain, the same reason oil separates from salad dressing.

Odor, Stability, and Storage Considerations

The smell won’t knock you down, but there’s a faint, sweet, almost fatty odor. Not unpleasant, though strong enough to pick out in a small lab. Much like many halogenated hydrocarbons, 1-Bromohexadecane delivers decent chemical stability if it’s kept out of the sun and away from strong acids or bases. Extended light exposure sometimes invites slow breakdown, so clear amber bottles and cool storage spots work best. Folks in labs learn this lesson early: careless storage leads to ruined experiments and, in bad cases, safety problems.

Why These Properties Matter Day-to-Day

My experience points back to those long afternoons in the lab, pipetting this material during surfactant synthesis and organic reactions. The high boiling point means regular glassware and open flames won’t quickly vaporize it—so you don’t lose your product in thin air. Low miscibility with water makes it effective in phase-transfer reactions or as an intermediate for further synthetic steps. People often overlook the irritation risk; lab gloves and ventilation aren’t just red tape, but necessary with oily halides. The persistent odor confirms any spills, and the slow flow helps prevent accidental splashes.

Backed by Trust and Science

Reliable data about properties like boiling point and density get cross-checked in respected sources: Sigma-Aldrich, PubChem, and published chemical handbooks. Chemistry doesn’t run on guesswork. I’ve leaned on these references every time our team planned a reaction, and no lab lets go of good sources—including the Merck Index and supplier SDS sheets. Safety info, melting/boiling details, and storage tips—these are core parts of working responsibly, and they reflect the commitment to evidence-based practice in science.

Working Toward Safer Use

Risks always come along with handling halogenated organics. Gloves, goggles, and fume hoods cut down on accidental exposure. Labs with proper labeling and storage routines prevent confusion, dangerous mixing, or accidental inhalation. Teaching these habits isn’t busywork—it keeps people safe, and upholds the standards expected in professional science. Clear understanding of 1-Bromohexadecane’s properties arms researchers and industry workers alike for better, safer work—out in the field, in the lab, or on the factory floor.

1-Bromohexadecane
1-Bromohexadecane
1-Bromohexadecane
Names
Preferred IUPAC name 1-Bromohexadecane
Other names Cetyl bromide
Bromohexadecane
Hexadecyl bromide
Pronunciation /ˌwʌnˌbroʊ.moʊ.hɛk.səˈdeɪn/
Identifiers
CAS Number 112-82-3
Beilstein Reference 1171054
ChEBI CHEBI:74572
ChEMBL CHEBI:34405
ChemSpider 67312
DrugBank DB11360
ECHA InfoCard ECHA InfoCard: 100_007_068
EC Number 203-893-9
Gmelin Reference 73148
KEGG C06402
MeSH D001932
PubChem CID 12414
RTECS number MI8575000
UNII R0T2P58A3D
UN number UN1993
Properties
Chemical formula C16H33Br
Molar mass 333.36 g/mol
Appearance Colorless to pale yellow liquid
Odor Odorless
Density 0.862 g/mL at 25 °C(lit.)
Solubility in water Insoluble
log P 8.94
Vapor pressure 0.000019 mmHg (25 °C)
Acidity (pKa) 14.6
Basicity (pKb) basicity (pkb): -1.48
Magnetic susceptibility (χ) -73.5e-6 cm³/mol
Refractive index (nD) 1.4370
Viscosity 5.1 cP (25 °C)
Dipole moment 2.59 D
Thermochemistry
Std molar entropy (S⦵298) 506.6 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -211.5 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) –10420.7 kJ/mol
Hazards
Main hazards Causes skin irritation, causes serious eye irritation, harmful if swallowed.
GHS labelling GHS02, GHS07
Pictograms GHS07
Signal word Warning
Hazard statements H315, H319, H335
Precautionary statements P210, P280, P305+P351+P338, P301+P312, P337+P313
Flash point 156 °C
Lethal dose or concentration LD50 (oral, rat): > 2000 mg/kg
LD50 (median dose) LD50 (median dose) of 1-Bromohexadecane: **5000 mg/kg (Rat, oral)**
NIOSH BJ4025000
PEL (Permissible) Not established
REL (Recommended) Fume hood
Related compounds
Related compounds 1-Iodohexadecane
1-Chlorohexadecane
1-Fluorohexadecane