Material Safety Data Sheet (MSDS) for 1-Bromobutane

Identification

Product Name: 1-Bromobutane
Chemical Formula: C4H9Br
CAS Number: 109-65-9
Synonyms: n-Butyl bromide, Butane bromide
Recommended Use: Laboratory reagent, organic synthesis intermediate
Manufacturer Details: Full address and emergency contact number should be available on the supplier's documentation
Emergency Contact: Chemtrec: 1-800-424-9300 (US)

Hazard Identification

Classification: Flammable liquids (Category 3), Acute toxicity - oral (Category 4), Skin irritation (Category 2), Eye irritation (Category 2A)
GHS Label Elements: Signal word: Warning; Hazard statements: H226 (Flammable liquid and vapor), H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation)
Symptoms: Nausea, dizziness, headache, coughing, skin redness, eye discomfort or watering
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Pictograms: Flame, Exclamation Mark

Composition / Information on Ingredients

Chemical Name: 1-Bromobutane
Concentration: ≥ 99% pure by weight
Impurities: May contain trace levels of 2-bromobutane, water, or n-butyl alcohol
Molecular Weight: 137.02 g/mol
Component Disclosure: Single ingredient material

First Aid Measures

Inhalation: Move affected person to fresh air immediately, keep at rest in a position comfortable for breathing, provide oxygen if breathing is difficult, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and plenty of water, seek medical help for irritation, do not reuse clothing until cleaned
Eye Contact: Rinse eyes slowly and gently with plenty of water for at least fifteen minutes, remove contact lenses if present and easy to do, get prompt medical care if irritation continues
Ingestion: Rinse mouth, do not induce vomiting unless directed by medical personnel, never give anything by mouth to an unconscious person, seek immediate medical help

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam, or water spray (do not use water jet)
Specific Hazards: Vapors may form explosive mixtures with air, gives off toxic fumes of hydrogen bromide and carbon oxides when burned
Special Protective Equipment: Wear self-contained breathing apparatus and protective suit, avoid inhalation of combustion products
Firefighting Instructions: Move containers from fire area if it can be done without risk, stay upwind, cool exposed containers with water spray, prevent run-off from entering drains or waterways

Accidental Release Measures

Personal Precautions: Evacuate area, remove all sources of ignition, ventilate area, avoid breathing vapors, use personal protective equipment including gloves and goggles
Environmental Precautions: Prevent leak and spill from entering drains, surface water, or soil, contain spill with inert material such as sand or vermiculite
Cleanup Methods: Absorb spill with non-combustible absorbent material, collect residue in chemical waste container, ventilate area thoroughly, wash spill site after material pick-up

Handling and Storage

Handling: Work in a well-ventilated space or fume hood, keep away from heat, sparks or open flames, avoid inhalation, contact with skin or eyes, use only in closed systems or properly vented containers
Storage: Store in tightly closed original container, keep in cool dry area away from incompatible substances (oxidizers, acids), store separately from food and beverages, keep container upright and protected from physical damage, label containers clearly
Other Recommendations: Bond and ground containers when transferring liquid, regularly inspect storage areas for leaks or deterioration

Exposure Controls and Personal Protection

Occupational Exposure Limits: ACGIH TLV – none assigned, OSHA PEL – none established
Engineering Controls: Local exhaust ventilation, safety shower and eyewash stations
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), splash goggles or face shield, lab coat or protective clothing, respirator if ventilation is inadequate
Hygiene Measures: Do not eat, drink or smoke around open product, wash hands thoroughly after handling, remove and wash contaminated clothing before reuse

Physical and Chemical Properties

Appearance: Colorless liquid
Odor: Sweet, chloroform-like odor
Boiling Point: 101-103°C (214-217°F)
Melting Point: -112°C (-170°F)
Flash Point: 24°C (75°F) closed cup
Evaporation Rate: Not established
Flammability: Flammable liquid
Vapor Pressure: 14 mmHg at 20°C
Solubility: Slightly soluble in water; miscible with alcohols and ethers
Specific Gravity: 1.27 at 20°C
Partition Coefficient (Log Kow): 2.89
Vapor Density: 4.7 (air = 1)
Auto-ignition Temperature: 230°C
Upper/Lower Flammable Limits: 1.3% - 9% (V)

Stability and Reactivity

Chemical Stability: Stable at normal temperatures and pressures
Incompatible Materials: Strong oxidizing agents, strong bases, alkali metals, powders of aluminum and magnesium
Hazardous Decomposition Products: Hydrogen bromide, carbon monoxide, carbon dioxide under fire conditions
Polymerization: Does not occur under normal conditions
Conditions to Avoid: Exposure to heat, sparks, open flame, incompatible substances, moisture

Toxicological Information

Acute Toxicity: LD50 Oral (rat): 2200 mg/kg; LD50 Dermal (rabbit): unreported but can irritate skin
Skin, Eye Effects: Can cause moderate irritation, redness, and discomfort
Inhalation Effects: May cause drowsiness, dizziness, coughing; excessive inhalation can cause central nervous system depression
Chronic Effects: Prolonged or repeated exposure may cause dermatitis or liver effects
Carcinogenicity: Not listed by IARC, NTP, or OSHA
Sensitization: Not a skin sensitizer
Other Data: Not mutagenic in Ames test; no evidence of reproductive toxicity in available studies

Ecological Information

Aquatic Toxicity: LC50 (fish): 205 mg/L (96 hr); EC50 (Daphnia magna): 180 mg/L (48 hr)
Persistence and Degradability: Not rapidly biodegradable, hydrolytically stable, may be slowly degraded by bacteria
Bioaccumulation Potential: Moderate, based on log Kow
Mobility in Soil: Moderately mobile, has potential to leach into groundwater
Other Ecotoxic Effects: Harmful to aquatic organisms in high concentrations, avoid release to the environment

Disposal Considerations

Waste Disposal Methods: Dispose of contents and container in accordance with local, state, and federal regulations, incinerate material at approved facility, do not discharge to sewer or surface water
Contaminated Packaging: Wash before reuse or dispose of as hazardous waste
Special Precautions: Avoid disposal with incompatible materials, wear proper personal protection during cleanup, use licensed hazardous waste hauler

Transport Information

UN Number: UN1126
Shipping Name: 1-Bromobutane
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Labels Required: Flammable liquid
Marine Pollutant: No
Special Transport Precautions: Secure containers upright and avoid rough handling, keep away from foodstuffs during transport

Regulatory Information

OSHA: Not specifically regulated as a hazardous chemical in the US, falls under general hazardous chemical handling guidelines
TSCA Inventory: Listed
SARA Title III: No Section 313 chemicals
REACH Registration: Required for import to the EU; follows European Community guidelines for safety, health, and environmental criteria
WHMIS Classification (Canada): B2 (flammable liquid), D2B (toxic material)
Other Regulatory Data: Ensure compliance with national and regional regulations regarding use, handling, transportation, and disposal of chemicals