Material Safety Data Sheet: 1-Bromo-5-Chloropentane

Identification

Product Name: 1-Bromo-5-Chloropentane
Synonyms: 5-Chloro-1-bromopentane
CAS Number: 54512-75-3
Recommended Use: Chemical synthesis, laboratory intermediary, specialty chemical production
Manufacturer: Chemical distributor or lab supplier typical for organic reagents
Emergency Contact: Use national poison control center or your local emergency number
Appearance: Clear, colorless to pale yellow liquid
Commercial Packaging: Glass bottles, sealed containers, chemical drums for industrial scale

Hazard Identification

Classification: Flammable liquid, skin irritant, eye irritant, acute toxicity by inhalation and ingestion
GHS Labels: Warning sign with flame and exclamation mark
Potential Health Effects: Causes burning sensation on skin and eyes, inhalation may affect respiratory tract, ingestion can harm gastrointestinal tract
Environmental Hazard: Harmful to aquatic life with long-lasting effects
Target Organs: Eyes, skin, respiratory system, digestive system
NFPA Ratings: Health: 2, Flammability: 2, Reactivity: 0

Composition / Information on Ingredients

Chemical Name: 1-Bromo-5-Chloropentane
Chemical Formula: C5H10BrCl
Concentration: ≥98% pure
Impurities: Possible traces of dibromopentane, hydrochloric derivatives
Molecular Weight: 185.49 g/mol

First Aid Measures

Inhalation: Move person to fresh air. Seek medical attention if symptoms persist. If not breathing, give artificial respiration.
Skin Contact: Remove contaminated clothing. Wash affected area with soap and water for several minutes. Consult physician if irritation develops.
Eye Contact: Rinse cautiously with water for several minutes, holding eyelids open. Remove contact lenses if possible. Get medical help.
Ingestion: Rinse mouth thoroughly with water. Do not induce vomiting. Seek immediate medical attention.
Important Notes: Medical providers should treat symptomatically. Persons giving aid should avoid exposure to themselves.

Fire-Fighting Measures

Suitable Extinguishers: Dry powder, carbon dioxide, alcohol-resistant foam.
Unsuitable Extinguishing Media: Water jet may spread the fire.
Special Fire Hazards: May emit hydrogen bromide, hydrogen chloride, carbon monoxide, carbon dioxide if burned.
Protective Equipment for Firefighters: Self-contained breathing apparatus and full protective gear.
Special Procedures: Cool exposed containers with water spray. Remove containers from fire area if safe.
Combustion Products: Corrosive and toxic gases

Accidental Release Measures

Personal Precautions: Evacuate area. Wear chemical-resistant gloves, eye protection, and respirator for vapors.
Environmental Precautions: Prevent spill from entering drains, sewers, or waterways. Notify environmental authorities if significant contamination occurs.
Containment: Stop leak if safe to do so. Surround spill with inert absorbent like vermiculite or sand.
Clean-up Methods: Absorb liquid with proper materials, collect in sealed chemical waste containers. Ventilate space.
Decontamination: Wash spill site after material has been cleaned up.

Handling and Storage

Handling: Use only in well-ventilated areas with chemical fume hood if possible. Avoid inhalation of vapors and contact with skin or eyes. Use dedicated equipment to prevent cross-contamination.
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing and wash before reuse.
Storage: Store in tightly sealed containers in a cool, dry, well-ventilated spot. Keep away from direct sunlight, heat sources, and incompatible materials such as strong bases or oxidizers.
Incompatible Materials: Avoid contact with alkali metals, strong acids, oxidizers.

Exposure Controls and Personal Protection

Exposure Limits: No established OSHA or ACGIH exposure limit; minimize exposure as a general work practice.
Engineering Controls: Use chemical fume hood, local exhaust ventilation. Maintain eyewash and safety shower in the workspace.
Personal Protective Equipment: Chemical splash goggles, lab coat, impervious gloves made of nitrile or neoprene, flame-resistant clothing if large quantities handled.
Respiratory Protection: Wear NIOSH-approved respirator in high vapor areas, or if ventilation is inadequate.
Environmental Protection: Proper containment; keep out of water sources and soil.

Physical and Chemical Properties

Appearance: Clear liquid
Odor: Mild halogenated hydrocarbon scent
Melting Point: -60°C
Boiling Point: 193-195°C
Flash Point: 74°C (closed cup)
Vapor Pressure: 0.3 mmHg at 25°C
Solubility: Insoluble in water, soluble in organic solvents like ether and alcohol
Density: 1.39 g/cm³
Partition Coefficient (log Kow): Estimated 2.1
Viscosity: Low, pours easily

Stability and Reactivity

Chemical Stability: Stable under normal conditions, especially if kept from water and strong bases
Conditions to Avoid: Heat, flames, ignition sources, sunlight
Incompatible Materials: Strong alkalis, oxidizing agents, active metals
Hazardous Decomposition: Hydrogen bromide, hydrogen chloride, bromine and chlorine-containing fumes under fire or decomposition
Polymerization: Does not polymerize under normal conditions.

Toxicological Information

Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity (oral): LD50 (rat): ~1,800 mg/kg (estimate based on related compounds)
Dermal Toxicity: Skin irritation likely after moderate contact
Inhalation: Headache, dizziness, mucous irritation possible at high vapor concentrations
Eye Effects: Contact causes burning, redness, possible temporary injury
Chronic Effects: No long-term studies; may cause liver or kidney effects after repeated exposure based on related halogenated alkanes
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a carcinogen
Mutagenicity/Teratogenicity: Insufficient data for assessment

Ecological Information

Aquatic Toxicity: Harmful to aquatic organisms, may cause long-term adverse effects in aquatic environments
Persistence and Degradability: Not readily biodegradable, moderately persistent
Bioaccumulative Potential: Potential to bioaccumulate in water organisms
Soil Mobility: Low due to hydrophobic properties
Other Adverse Effects: May disrupt normal microbial processes if released in significant quantities.

Disposal Considerations

Disposal Methods: Incinerate in approved chemical incinerators with appropriate scrubbing technology for halogenated compounds
Prohibited Practices: Do not discharge to sewers, surface water, or ground; avoid open burning
Empty Containers: Triple rinse, remove labels, pass to chemical waste handler
Consult Regulations: Dispose according to local, regional, national, and international rules

Transport Information

UN Number: UN 1993
UN Proper Shipping Name: Flammable Liquid, N.O.S. (contains 1-Bromo-5-Chloropentane)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Labeling Requirements: Flammable liquid labels required
Marine Pollutant: Yes, limited quantities excepted for some methods of shipment
Special Transport Precautions: Keep away from ignition sources, handle as hazardous chemical

Regulatory Information

TSCA Inventory: Listed
REACH Status: Requires registration if imported into EU≥1 tonne/year
US EPA SARA 302/304/313: Not specifically listed
OSHA Hazard Chemicals: Regulated for workplace exposure, specific guidelines for chemical hygiene plans
California Prop 65: Not listed
Other National Regulations: Comply with international, federal, state, and local chemical safety and environmental regulations
Workplace Labeling: Follow GHS-compliant hazard communication, keep safety data on hand for personnel