Material Safety Data Sheet: 1-Bromo-4-Tert-Butylbenzene

Identification

Product Name: 1-Bromo-4-Tert-Butylbenzene
Synonyms: 4-tert-Butylbromobenzene, p-(tert-Butyl)Bromobenzene
CAS Number: 770-12-7
Recommended Use: Intermediate for organic synthesis and laboratory research
Company Information: Supplier details, address, emergency contact number

Hazard Identification

GHS Classification: Harmful if inhaled, Causes skin and eye irritation, Possible environmental hazard
Signal Word: Warning
Hazard Statements: H315 – Causes skin irritation, H319 – Causes serious eye irritation, H335 – May cause respiratory irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, Use only outdoors or in a well-ventilated area, Wear protective gloves, Wash face and hands after handling, Dispose of contents/container in accordance with local, national regulations
Potential Health Effects: Prolonged exposure to vapors may cause headaches or dizziness; skin contact can cause inflammation

Composition / Information on Ingredients

Chemical Identity: 1-Bromo-4-Tert-Butylbenzene
Chemical Formula: C10H13Br
Component: 1-Bromo-4-Tert-Butylbenzene (≥99%)
Impurities: Residual organic solvents (trace), No significant hazardous impurities present

First Aid Measures

Inhalation: If symptoms develop, move to fresh air. Seek medical attention if breathing becomes abnormal.
Skin Contact: Immediately wash exposed area with soap and plenty of water for at least fifteen minutes. Remove contaminated clothing and wash before reuse.
Eye Contact: Rinse cautiously with water for several minutes, lifting eyelids to ensure thorough flushing. Seek medical help if irritation persists.
Ingestion: Rinse mouth thoroughly, do not induce vomiting. Obtain immediate medical attention if large amounts have been ingested.
Most Important Symptoms/Effects: Irritation of eyes, skin, or respiratory tract. Extended exposure may bring central nervous system effects.

Fire-Fighting Measures

Suitable Extinguishing Media: Use dry chemical, foam, carbon dioxide, or water spray to douse flames
Specific Hazards: Combustion can produce irritating or toxic fumes including bromine vapors, carbon oxides
Protective Equipment: Firefighters need self-contained breathing apparatus and protective gear
Firefighting Instructions: Remove containers from area if safe. Cool exposed drums or tanks with water spray. Avoid inhaling fumes during fire response.
Flammability: Not highly flammable but may burn under intensive conditions

Accidental Release Measures

Personal Precautions: Wear appropriate respirator, chemical-resistant gloves, protective goggles, and clothing. Evacuate area and prevent unauthorized entry.
Environmental Precautions: Prevent spill from entering waterways, drains, or soil. Alert environmental authorities in case of major leaks.
Containment & Cleanup: Ventilate area. Absorb spilled material with authorized absorbent (sand, inert material). Place in closed containers for approved disposal. Wash affected surface with water and detergent.

Handling and Storage

Safe Handling: Operate in a well-ventilated zone. Prevent formation of vapors, mists, or dust. Avoid contact with skin, eyes, and clothing. Do not eat, drink, or smoke during use.
Storage Requirements: Store in tightly closed, properly labeled containers. Keep in a cool, dry, and well-ventilated area, away from sunlight and incompatible substances like strong oxidizers.
Hygiene Practices: Remove contaminated clothing. Wash hands and face before breaks and after work. Maintain proper labeling and access to safety showers/eyewash stations.

Exposure Controls and Personal Protection

Exposure Limits: No occupational exposure limit for this compound, observe safe laboratory practices
Engineering Controls: Use chemical fume hood or ventilation system to reduce airborne exposure
Personal Protection: Chemical-resistant gloves (nitrile or neoprene recommended), safety goggles, lab coat or apron, and in rare high-exposure situations, suitable respirator
Environmental Controls: Prevent substance from escaping into public sewers or waterways by using containment systems

Physical and Chemical Properties

Appearance: Clear to pale yellow liquid
Odor: Faint aromatic
Solubility: Insoluble in water; miscible with most organic solvents
Melting Point: Approximately -8°C
Boiling Point: 246-247°C
Density: About 1.16 g/cm³
Vapor Pressure: Low at room temperature
Flash Point: Above 110°C (closed cup)
Autoignition Temp: Not well established
pH: Not applicable
Partition Coefficient (n-octanol/water): High value indicates strong affinity for organic phases

Stability and Reactivity

Chemical Stability: Stable under normal temperature and pressure conditions
Possible Hazardous Reactions: May react with strong oxidizing agents, acids, or reducing substances
Conditions to Avoid: Extreme heat, open flames, direct sunlight
Incompatible Materials: Strong oxidizers, strong acids, reducing agents
Decomposition Products: Releases bromine compounds, carbon monoxide, carbon dioxide under combustion or thermal breakdown

Toxicological Information

Acute Toxicity: Lower oral and inhalation toxicity, but can irritate mucosa
Skin Corrosion/Irritation: Repeated contact may provoke redness, dryness, or cracking
Eye Damage/Irritation: Short-term eye exposure can cause stinging, redness, or blurred vision
Respiratory Effects: Inhalation of vapors or mist may irritate respiratory tract, trigger coughing or discomfort
Chronic Effects: Prolonged exposure data limited, no known significant long-term hazards from casual contact
Carcinogenicity: Not listed by IARC, NTP, or OSHA
Sensitization: No documented cases of skin or respiratory sensitization
Other Effects: Central nervous system depression possible at very high doses

Ecological Information

Aquatic Toxicity: Harmful to aquatic life, potential for long-lasting effects in water bodies
Persistence & Degradability: Expected to be poorly biodegradable
Bioaccumulation Potential: High risk of accumulation in aquatic organisms
Mobility: Low solubility in water suggests limited mobility in soil and surface waters
Other Adverse Effects: Avoid release to the environment, especially into surface water or soil where breakdown is slow

Disposal Considerations

Waste Disposal Methods: Collect in sealed, properly labeled containers. Handle as hazardous waste in accordance with local, state, national, or international regulations.
Waste Treatment Procedures: Incineration by licensed operators preferred. Do not pour down the drain or release into environment.
Contaminated Packaging: Dispose of empty containers through hazardous waste procedures, following all chemical hygiene rules

Transport Information

UN Number: UN 1993
Transport Hazard Class: 3 (Flammable Liquids, though product has low flammability at ambient temperature)
Packing Group: III
Proper Shipping Name: Flammable Liquid, n.o.s. (1-Bromo-4-Tert-Butylbenzene)
Special Precautions: Ensure containers are properly sealed and labeled. Protect from physical damage or excessive heat during transport.
Environmental Hazards: Marked as marine pollutant when shipped by sea

Regulatory Information

OSHA Hazard Communication Standard: Hazardous chemical under 29 CFR 1910.1200
TSCA Status: Listed in United States TSCA inventory
REACH Registration: Included in European chemical inventory
Other Regulations: Subject to SARA Title III reporting where quantities exceed thresholds
Workplace Controls: OSHA standards enforce strict labeling and hazard management
Label Requirements: Clearly marked with chemical name, hazard pictograms, and relevant handling instructions
Supplemental National and Local Regulations: Observe additional restrictions or recommendations in specific jurisdictions or countries