Material Safety Data Sheet: 1-Bromo-4-Chlorobutane

Identification

Product Name: 1-Bromo-4-Chlorobutane
Synonyms: 4-Chlorobutyl bromide, 1-Bromobutyl-4-chloride
Chemical Formula: C4H8BrCl
Molecular Weight: 171.47 g/mol
CAS Number: 6940-78-9
Recommended Usage: Organic synthesis, chemical research, intermediate for medicines and pesticides
Manufacturer Contact: Emergency phone included on container label, reliable source info required before purchase; consult supplier for emergencies and technical support

Hazard Identification

Classification: Flammable liquid, skin irritant; Hazard Class 3 (flammable liquids), Specific Target Organ Toxicity (single exposure)
Label Elements: Danger symbol on container, hazardous pictogram (flame, exclamation mark), signal word “Danger”
Hazard Statements: Harmful if swallowed, contact with skin causes irritation, inhalation results in respiratory tract irritation, contact with eyes causes severe irritation, vapors may be harmful, long-term exposure harms nervous system
Precautionary Statements: Keep away from heat/sparks/open flames, avoid breathing vapors, wear protective gear, use in well-ventilated spaces, wash skin thoroughly after handling, store locked up, ingesting can cause nausea, vomiting, dizziness, coughing, eye redness, or burning sensation

Composition / Information on Ingredients

Chemical Name: 1-Bromo-4-Chlorobutane
CAS Number: 6940-78-9
Concentration: 98% minimum
Impurities: Trace moisture, halogenated byproducts (below 2%)
Other Ingredients: No known stabilizers, no other hazardous additives present under typical storage; impurities rarely present unless exposed to air, moisture, or heat

First Aid Measures

Inhalation: Remove person to fresh air, provide oxygen for breathing difficulty, seek medical help if symptoms persist, avoid direct exposure
Skin Contact: Wash with soap and water for 15 minutes, remove contaminated clothing, call physician for burns or persistent irritation
Eye Contact: Rinse with water for at least 15 minutes while lifting eyelids, do not rub eyes, remove contact lenses, seek medical help for eye pain or vision difficulties
Ingestion: Rinse mouth (if alert), never give anything by mouth to an unconscious person, do not provoke vomiting, seek immediate medical attention

Fire-Fighting Measures

Suitable Extinguishing Media: Carbon dioxide, dry chemical, alcohol-resistant foam, do not use direct water jets
Special Hazards: Flammable liquid releases toxic fumes (hydrogen bromide, hydrogen chloride, carbon monoxide) under heat, vapor forms explosive mixture with air, risk of re-ignition
Protective Equipment: Firefighters wear full self-contained breathing apparatus, flame-resistant clothing
Fire-Fighting Instructions: Evacuate area, cool containers with water from a safe distance to prevent explosion, contain runoff using sand or earth

Accidental Release Measures

Personal Precautions: Wear chemical splash goggles, nitrile gloves, chemical-resistant clothing, avoid vapor inhalation, no open flames or unprotected electrical equipment nearby
Environmental Precautions: Prevent runoff to waterways, contain spill with non-combustible absorbent (vermiculite, sand), report contamination of soil, sewer, or water to authorities
Cleanup Methods: Ventilate area, use spark-proof tools, collect absorbent and place in chemical waste container, decontaminate area using detergent and rinse with water, secure for approved disposal

Handling and Storage

Handling: Only handle in chemical fume hood with splash protection, minimize vapor exposure, static discharge strict control, wear proper PPE including gloves, goggles, lab coat, avoid contacting incompatible materials
Storage: Store in cool, dry, well-ventilated location, keep containers tightly closed, segregate from oxidizers, acids, alkalis, do not store near heat or ignition sources, secondary containment essential for bulk quantities, dedicate area for hazardous chemical inventory

Exposure Controls and Personal Protection

Engineering Controls: Chemical fume hood standard, explosion-proof exhaust fans for larger-scale work, safety showers and eye-wash stations in proximity
Personal Protective Equipment: Chemical splash goggles with face shield if splashing is likely, nitrile or neoprene gloves, flame-retardant lab coat, closed-toe shoes, avoid contact lenses during handling
Exposure Limits: No OSHA or ACGIH exposure limits established, minimize risk with good ventilation and personal monitoring; avoid working alone when handling substantial amounts

Physical and Chemical Properties

Appearance: Clear, colorless to pale yellow liquid
Odor: Pungent, halogenated, faintly sweetish
pH: Not applicable
Melting Point: -88°C
Boiling Point: 162°C
Flash Point: 51°C (closed cup)
Vapor Pressure: Approx. 1.3 mm Hg at 20°C
Density: 1.497 g/cm³
Solubility: Insoluble in water, soluble in organic solvents such as ether, chloroform
Viscosity: Low
Partition Coefficient (log Kow): Estimated: 2.6
Auto-Ignition Temperature: Not determined
Evaporation Rate: Slower than ethyl ether

Stability and Reactivity

Chemical Stability: Stable under recommended storage, exposure to heat increases gas evolution risk, light gradually degrades material
Reactivity: Reacts with strong bases and oxidizers, forms hazardous byproducts if mixed with acids, incompatible with soft metals, aluminum
Decomposition Products: Releases hydrogen chloride, hydrogen bromide, carbon oxides when burned or overheated
Conditions to Avoid: Avoid open flames, sparks, direct sunlight, excess moisture

Toxicological Information

Acute Toxicity: Orally toxic if swallowed, rat LD50 estimated at 740 mg/kg; inhalation causes respiratory tract irritation and drowsiness, skin exposure triggers corrosion or severe irritation
Chronic Toxicity: Prolonged or repeated exposure may result in liver, kidney, neurological, or respiratory damage
Routes of Exposure: Eyes, skin, ingestion, inhalation
Symptoms: Burning sensation, cough, dizziness, headache, abdominal pain, blurry vision, chemical burns for skin/eye contact; delayed symptoms may include nervous system depression
Sensitization/Carcinogenicity: Not determined, no current listing by IARC, NTP, OSHA for this compound
Mutagenicity/Reproductive Effects: Not enough evidence; avoid prolonged or repeated use pending further data

Ecological Information

Ecotoxicity: Harmful to aquatic life, acute toxicity possible for fish, daphnia, and invertebrates at low concentrations, toxic to plankton and aquatic microorganisms
Persistence/Degradability: Moderately persistent, does not degrade rapidly in environment, slow hydrolysis; presents risk of groundwater contamination
Bioaccumulative Potential: Estimated log Kow suggests moderate risk of accumulation in aquatic organisms
Mobility in Soil: Low mobility, likely to adsorb to organic matter, runoff risk present with spills on impervious surfaces
Other Effects: Avoid environmental release, do not wash into drains or waterway, bioaccumulation has secondary risk for higher food chain organisms

Disposal Considerations

Disposal Methods: Treat as hazardous chemical waste, collect spill residues and contaminated material for certified disposal, consult local disposal regulations and chemical tracking requirements, typical incineration at licensed waste facility
Container Disposal: Triple-rinse with appropriate solvent before disposal, remove or deface hazard labels
Precautions: Never dump in sewage, landfill, or open ground, maintain waste manifest and chain of custody for all discard action

Transport Information

UN Number: 1993
Proper Shipping Name: Flammable Liquid, N.O.S. (contains 1-Bromo-4-chlorobutane)
Transport Hazard Class: 3 (flammable liquid)
Packing Group: III
Marine Pollutant: Yes
Transport Labels: Flammable liquid pictogram required
Special Requirements: Secure tightly sealed containers, notify carrier of hazardous content, fire extinguishers during transport, protect from sunlight, separation from foodstuffs and compatible chemicals

Regulatory Information

International Inventory Status: Registered under TSCA (US), listed in EINECS (EU), consult local chemical inventories for specific regions
Hazard Communication: Meets OSHA Hazard Communication Standard (29 CFR 1910.1200), hazard labels required for container
EPA Regulations: Not specifically listed on SARA Title III or CERCLA, check for VOCs category inclusion
Canadian Regulations: WHMIS classification: Class B-2 (flammable liquid), Class D-1B (toxic material)
Restrictions: Sale and use may be regulated; consult national and local authorities for workplace limits and public health notifications
Labelling Requirements: Provide safety training for workers before use, maintain SDS access on premises, renew safety compliance annually