Material Safety Data Sheet: 1-Bromo-2-Chloroethane

Identification

Product Name: 1-Bromo-2-Chloroethane
Chemical Formula: C2H4BrCl
Synonyms: Ethane, 1-bromo-2-chloro-; Ethylene bromochloride
CAS Number: 107-04-0
Product Code: Typically referenced as B0962
Manufacturer: Large chemical suppliers, laboratory suppliers, and brokers worldwide, with specific details on request
Uses: Commonly found in research, chemical synthesis, and the pharmaceutical industry

Hazard Identification

GHS Classification: Acute toxicity (oral, dermal, inhalation), Skin and eye irritation, Specific target organ toxicity
Pictogram: Skull and crossbones, exclamation mark
Signal Word: Danger
Primary Routes of Exposure: Skin, eyes, inhalation
Potential Health Effects: Causes skin and eye irritation, harmful if swallowed or inhaled, can cause central nervous system depression, may affect liver and kidney function on prolonged exposure
Environmental Hazards: Toxic to aquatic life with long-lasting effects
Hazard Statements: H302: Harmful if swallowed; H315: Causes skin irritation; H319: Causes serious eye irritation; H332: Harmful if inhaled; H410: Very toxic to aquatic life with long-lasting effects
Precautionary Statements: P273: Avoid release to the environment; P280: Wear protective gloves/protective clothing/eye protection/face protection; P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell

Composition / Information on Ingredients

Chemical Name: 1-Bromo-2-Chloroethane
CAS Number: 107-04-0
Percent Purity: >98% (varies by supplier)
Impurities: May include trace amounts of other haloethanes (less than 1%)
Molecular Weight: 143.42 g/mol
EC Number: 203-457-6

First Aid Measures

Inhalation: Move person to fresh air. Seek medical attention if symptoms develop or persist; administer oxygen if breathing is difficult
Skin Contact: Immediately wash skin with plenty of soap and water for at least 15 minutes, remove contaminated clothing and shoes, launder before reuse, seek medical advice if redness or irritation remain
Eye Contact: Rinse cautiously with water for several minutes, lifting upper and lower lids occasionally; remove contact lenses if present and easy; obtain medical advice
Ingestion: Rinse mouth, do not induce vomiting unless instructed by medical personnel, seek immediate medical attention
Most Important Symptoms: Irritation, dizziness, headache, nausea, burning sensations
Immediate Medical Attention: Necessary for any significant exposure due to central nervous system depressant potential

Fire-Fighting Measures

Extinguishing Media: Use CO2, dry chemical extinguishers, or foam; water spray may spread the fire
Unsuitable Extinguishing Media: Avoid direct water jets, which may be inefficient
Special Hazards: Releases hazardous vapors, including HCl, HBr, carbon monoxide, carbon dioxide
Protection for Firefighters: Wear self-contained breathing apparatus and full protective clothing
Fire/Explosion Risks: Vapors heavier than air; can accumulate in low areas and pose risk of flashback
Thermal Decomposition: Produces toxic gases and fumes under fire conditions

Accidental Release Measures

Personal Precautions: Evacuate personnel from the area, ensure adequate ventilation, avoid breathing vapors or mists, wear suitable protective equipment
Environmental Precautions: Prevent further leakage or spillage if safe, do not let product enter drains, soil, or surface water
Cleanup Methods: Contain spill with inert absorbent material (sand, earth, vermiculite), collect in a suitable closed container for disposal, ventilate area, thoroughly clean contaminated surfaces
Additional Advice: Remove sources of ignition, restrict access until cleanup is complete

Handling and Storage

Safe Handling: Use only in a well-ventilated area, avoid contact with skin, eyes, and clothing, do not breathe vapors; use personal protective equipment as recommended
Storage Conditions: Store in tightly closed containers in a cool, dry, and well-ventilated place, away from heat sources, sparks, flames, and incompatible substances
Incompatible Materials: Strong acids, bases, oxidizing agents, reducing agents
Special Requirements: Ground containers and equipment to prevent static electricity discharge, label clearly, limit access to trained personnel
Storage Temperature: Store below 25°C for best stability

Exposure Controls and Personal Protection

Control Parameters: No established ACGIH TLV or OSHA PEL; minimize exposure as much as possible
Engineering Controls: Use local exhaust ventilation, chemical fume hood, or equivalent ventilation
Personal Protective Equipment:
Respiratory Protection: Full-face respirator with organic vapor cartridge or supplied-air respirator if exposure levels exceed recommendations
Hand Protection: Chemical-resistant gloves (nitrile, neoprene)
Eye Protection: Chemical safety goggles
Skin Protection: Lab coat, apron, or full chemical-resistant suit as needed
Hygiene Measures: Wash hands and face thoroughly after handling, do not eat or drink near chemical, remove contaminated clothing

Physical and Chemical Properties

Appearance: Colorless to faintly yellow transparent liquid
Odor: Sweet, ether-like odor
Odor Threshold: Not determined
Boiling Point: 109–111°C
Melting Point: −70°C
Flash Point: >65°C (closed cup)
Evaporation Rate: Not available
Flammability: Not classified as flammable but combustible at high temperatures
Vapor Pressure: 14 mm Hg at 20°C
Vapor Density: 4.97 (air = 1)
Solubility: Slightly soluble in water, miscible with ether and alcohol
Partition Coefficient (n-octanol/water): 2.08
Auto-ignition Temperature: Not determined
Decomposition Temperature: Not available
Viscosity: Not available
Specific Gravity: 1.62 (water = 1)

Stability and Reactivity

Chemical Stability: Remains stable under normal storage and handling conditions
Possible Hazardous Reactions: Reacts vigorously with strong bases, strong oxidizers, reducing agents, alkali or alkaline earth metals, can cause explosions on contact
Conditions to Avoid: Heat, open flame, sparks, incompatible materials
Hazardous Decomposition Products: Hydrogen chloride, hydrogen bromide, carbon monoxide, carbon dioxide
Polymerization: Not reported under normal conditions

Toxicological Information

Acute Toxicity: LD50 (oral, rat): 240 mg/kg; LD50 (dermal, rabbit): data limited
Chronic Toxicity: No conclusive data for chronic effects but long-term exposure may cause central nervous system effects, possible liver and kidney injury
Routes of Exposure: Eyes, skin contact, inhalation, ingestion
Symptoms: Skin/eye irritation, respiratory irritation, dizziness, nausea, vomiting, unconsciousness can occur on high exposure
Carcinogenicity: Not classified as carcinogenic by IARC, ACGIH, NTP, OSHA
Mutagenicity: No definitive data available, treat with caution
Reproductive Effects: Insufficient data
Target Organ Effects: Liver, kidneys, central nervous system

Ecological Information

Ecotoxicity: Toxic to aquatic life even at low concentrations, with potential for long-term adverse effects
Persistence and Degradability: Not readily biodegradable, tends to persist in the environment
Bioaccumulative Potential: Moderate, based on log Kow
Mobility in Soil: Low to moderate, subject to leaching
Other Adverse Effects: May contaminate water bodies and harm aquatic ecosystems if not managed properly

Disposal Considerations

Disposal Methods: Handle as hazardous waste, dispose through licensed chemical waste contractor
Contaminated Packaging: Dispose of securely using approved incineration or landfilling procedures consistent with local, national, and international regulations
Precautions: Do not dispose into sewage system, drain, or natural environment, keep waste containers sealed and properly labeled

Transport Information

UN Number: UN 1992
Proper Shipping Name: Flammable liquid, toxic, n.o.s. (contains 1-Bromo-2-Chloroethane)
Transport Hazard Class: 3 (Flammable liquid), 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Marine pollutant
Special Precautions for Transport: Ensure containers are tightly sealed, secure upright, protect from physical damage, adhere to local and international shipping regulations

Regulatory Information

TSCA (US): Listed
EINECS/ELINCS (EU): Listed (203-457-6)
DSL/NDSL (Canada): Listed
RoHS Status: Not specifically regulated for electronics, but hazardous properties call for caution
Safety, Health and Environmental Regulations: Subject to national chemical safety acts, Occupational Safety and Health regulations, and environmental protection statutes; often classified as a hazardous substance under workplace and environmental hazard legislation
Restrictions: Use and handling may be subject to reporting and record-keeping depending on jurisdiction