Material Safety Data Sheet for 1,6-Dibromohexane

Identification

Product Name: 1,6-Dibromohexane
Chemical Formula: C6H12Br2
CAS Number: 629-03-8
Recommended Use: Research, synthesis of organic compounds, intermediate for pharmaceuticals
Supplier Details: Chemical manufacturer or laboratory supply distributor’s contact, emergency contact number

Hazard Identification

Classification: Flammable Liquids (Category 4), Skin Irritation (Category 2), Eye Irritation (Category 2A), Specific Target Organ Toxicity Single Exposure (Category 3)
Label Elements: Signal Word: Warning
Hazard Statements: Causes skin irritation, causes serious eye irritation, may cause respiratory irritation, harmful to aquatic life with long-lasting effects
Pictograms: Exclamation mark, Environment
Precautionary Statements: Avoid breathing vapors, wear gloves and eye protection, avoid release to environment, wash hands thoroughly after handling

Composition / Information on Ingredients

Substance: 1,6-Dibromohexane
Synonyms: Hexamethylene dibromide
Chemical Family: Alkyl halide
Concentration: >99%
Impurities: Trace amounts of byproducts from manufacturing process, may include mono-brominated hexane compounds

First Aid Measures

General Advice: Seek medical attention if symptoms persist
Inhalation: Move to fresh air, keep at rest, seek medical attention for breathing difficulty
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, consult a physician for persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing and get medical help if irritation continues
Ingestion: Rinse mouth with water, do not induce vomiting, contact poison control and seek emergency help

Fire-Fighting Measures

Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam
Hazards: Combustion releases toxic fumes including hydrogen bromide, carbon monoxide, carbon dioxide
Advice for Firefighters: Wear self-contained breathing apparatus and protective clothing, avoid inhalation of fire-generated gases, use water spray to cool exposed containers
Flash Point: 94°C (201°F)
Special Procedures: Prevent fire-fighting runoff from entering drains and watercourses

Accidental Release Measures

Personal Precautions: Evacuate area, ensure adequate ventilation, use personal protective equipment including gloves, goggles, and suitable respirator
Environmental Precautions: Prevent further leakage or spillage if safe to do, avoid discharge into drains, surface and ground waters
Methods for Cleanup: Absorb spill with inert material such as sand or diatomaceous earth, collect and seal in properly labeled container, ventilate area, wash spill site after material pickup is complete
Small Spills: Wipe up with paper towel and dispose according to local regulations
Large Spills: Contain and collect with non-combustible absorbent material, follow local disposal requirements

Handling and Storage

Handling: Use in well-ventilated area, avoid contact with skin, eyes, and clothing, do not breathe vapors, keep away from heat and ignition sources, handle away from incompatible substances such as strong oxidizers
Storage: Store in tightly closed original container, cool, dry and well-ventilated location, away from direct sunlight, segregate from oxidizing and strong alkaline materials, maintain temperature below 30°C, keep away from food and drink
Other Precautions: Ensure proper labeling of container, regularly check for leaks or deterioration, provide safety shower and eyewash station in workspace

Exposure Controls and Personal Protection

Engineering Controls: Use fume hood and local exhaust ventilation, provide safety equipment for accidental exposure
Personal Protective Equipment: Chemical-resistant gloves (nitrile), protective chemical splash goggles, flame-resistant lab coat, closed footwear
Respiratory Protection: Use NIOSH-approved full face respirator if vapor formation is suspected
Hygiene Measures: Wash hands, face, and any exposed skin thoroughly after handling, avoid eating or drinking in the work area, clean contaminated clothing before reuse
Control Parameters: No established OSHA, NIOSH, or ACGIH exposure limits for 1,6-Dibromohexane

Physical and Chemical Properties

Appearance: Clear, colorless to pale yellow liquid
Odor: Mild, characteristic
Odor Threshold: Not determined
Boiling Point: 252 - 254°C
Melting Point: -1°C
Flash Point: 94°C (Tag Closed Cup)
Auto-ignition Temperature: Data unavailable
Explosive Limits: Lower and upper explosive limits not determined
Vapor Pressure: 0.1 mmHg at 25°C
Density: 1.487 g/cm³ at 20°C
Solubility in Water: Insoluble
Partition Coefficient (log Kow): 3.33
Evaporation Rate: Data unavailable
Viscosity: Not measured
pH: Not applicable

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions, decomposes on prolonged exposure to air and light
Materials to Avoid: Strong oxidizing agents, strong bases, reducing agents
Hazardous Decomposition Products: Carbon oxides, hydrogen bromide, bromine vapors
Conditions to Avoid: Excessive heat, flames, ignition sources, exposure to sunlight
Polymerization: No hazardous polymerization reported

Toxicological Information

Acute Toxicity: LD50 (oral, rat): 1090 mg/kg
Inhalation: May cause respiratory tract irritation, dizziness, headache, high concentrations can depress central nervous system
Skin Contact: Causes mild to moderate skin irritation
Eye Contact: Causes severe irritation, possible corneal injury
Chronic Effects: Prolonged or repeated exposure can result in dermatitis, sensitization not well documented
Mutagenicity/Carcinogenicity: Not classified as human carcinogen by IARC, OSHA, or NTP. No mutagenic effects reported in standard tests
Reproductive Toxicity: No data available
Other Information: Harmful by ingestion, aspiration into lungs may result in chemical pneumonitis

Ecological Information

Toxicity to Aquatic Life: LC50 (fish, 96 hr): 3.3 mg/L (estimated)
Persistence and Degradability: Not readily biodegradable, likely to partition to sediment
Bioaccumulation: BCF (fish): 400 (predicted), potential for moderate bioaccumulation
Mobility in Soil: Low mobility, will adsorb to organic matter
Other Harmful Effects: May be toxic to aquatic organisms even at low concentrations, avoid direct release to water sources
Ozone Depletion: Not expected to contribute to ozone depletion

Disposal Considerations

Disposal Methods: Collect and transfer to a disposal facility in accordance with federal, state, and local regulations, incinerate in approved chemical incinerator equipped with afterburner and scrubber
Container Disposal: Empty containers may retain product residue, treat as hazardous waste, dispose properly
RCRA Status: Not listed as a hazardous waste under RCRA, generator is responsible for waste classification
Precautions: Do not dispose into drains, prevent contamination of soil, ground, and surface water

Transport Information

UN Number: UN 2810
UN Proper Shipping Name: Toxic liquid, organic, n.o.s. (1,6-Dibromohexane)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Label: Toxic
Environmental Hazards: Marine pollutant
Special Precautions: Follow hazardous material shipment protocols, use provided protective packaging, report any incidents during shipment to relevant authorities
Transport Regulations: Subject to international and national transport regulations (ADR/RID/IMDG/IATA)

Regulatory Information

TSCA (US): Listed
REACH (EU): Registered or pre-registered
SARA Title III: Not subject to Section 302/304/313 reporting
California Proposition 65: Not listed
WHMIS (Canada): D2B (Toxic, skin/eye irritant)
Inventory Status: Listed in AICS (Australia), DSL (Canada), EINECS (Europe), ENCS (Japan), NZIoC (New Zealand), PICCS (Philippines), KECI (Korea)
Other Information: Always check country-specific requirements, adhere strictly to local and international chemical handling regulations