1,6-Dibromohexane Material Safety Data Sheet (MSDS)

Identification

Product Name: 1,6-Dibromohexane
Chemical Formula: C6H12Br2
CAS Number: 629-03-8
Synonyms: Hexamethylene dibromide
Recommended Use: Intermediate for organic synthesis, research, and industrial chemistry
Supplier Information: Manufacturer or distributor contact details, including address, phone number, and emergency contact

Hazard Identification

Hazard Classification: Acute toxicity (oral, dermal, inhalation); skin and eye irritation; suspected of causing genetic defects
Label Elements: GHS pictograms for toxic, irritant, and health hazard; hazard statements such as ‘Harmful if swallowed or inhaled’, ‘Causes skin and eye irritation’, ‘Suspected of causing genetic defects’
Precautionary Statements: Use personal protective equipment, avoid breathing vapors, prevent contact with skin or eyes, wash hands after handling, dispose of contents in accordance with regulations

Composition / Information on Ingredients

Chemical Identity: 1,6-Dibromohexane
Purity: Greater than 98%
Impurities: None above reportable thresholds as indicated by supplier, trace by-products may exist from synthesis
Molecular Weight: 259.97 g/mol

First Aid Measures

Inhalation: Remove individual to fresh air, supply oxygen if breathing is difficult, consult a physician for persistent symptoms
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water for at least 15 minutes, seek medical attention if irritation develops
Eye Contact: Flush eyes with copious amounts of water for at least 15 minutes while lifting eyelids; immediate medical evaluation recommended
Ingestion: Do not induce vomiting, rinse mouth thoroughly, call poison control or emergency medical services promptly, provide symptom-specific treatment as necessary
Most Important Acute and Delayed Symptoms: Pain, redness, irritation, respiratory discomfort, gastrointestinal upset

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Unsuitable Extinguishing Media: Do not use water jet directly on substance as it could spread fire
Specific Hazards: Combustion releases hydrogen bromide, carbon oxides, and other toxic fumes
Protective Equipment: Firefighters should wear protective gear and self-contained breathing apparatus
Advice: Control run-off to prevent entry into sewers or waterways; containers may burst under heat
Special Procedures: Isolate area, stay upwind, use water spray to cool fire-exposed containers, avoid inhaling smoke

Accidental Release Measures

Personal Precautions: Evacuate area, ventilate space, avoid breathing vapors, wear suitable protective clothing, gloves, and eye protection
Environmental Precautions: Prevent further leakage or spillage, do not let product enter drains, surface water, or soil
Cleanup Methods: Absorb spill with inert material such as sand or vermiculite, sweep up and dispose of according to local regulations, decontaminate spill area with detergent and water

Handling and Storage

Handling: Avoid inhalation, ingestion, and skin or eye contact; use in well-ventilated areas, wear appropriate PPE at all times, use closed systems for transfers when possible
Storage: Store in tightly closed container in cool, dry, well-ventilated location, away from oxidizing agents, acids, and moisture, segregate from food or beverages
Safe Handling Advice: Keep out of reach of children, restrict access to trained personnel, label all containers clearly, prevent static electricity build-up during transfers

Exposure Controls and Personal Protection

Occupational Exposure Limits: No official threshold limit value (TLV) established, minimize exposure as much as possible; refer to local regulations
Engineering Controls: Use fume hoods, local exhaust ventilation, or process enclosures to reduce airborne concentrations
Personal Protective Equipment: Chemical splash goggles, chemical-resistant gloves (e.g. nitrile), lab coat or apron, closed footwear, use respiratory protection if ventilation is insufficient
Hygiene Measures: No eating, drinking, or smoking in work area, wash hands thoroughly after handling, remove contaminated clothing immediately

Physical and Chemical Properties

Appearance: Clear to pale yellow oily liquid
Odor: Mild, sweet, characteristic
pH: Not applicable
Boiling Point: 255–256 °C
Melting Point: -2 °C
Flash Point: 120 °C closed cup
Evaporation Rate: Not available
Flammability: Not highly flammable, can sustain combustion under certain conditions
Vapor Pressure: Low at room temperature
Solubility: Insoluble in water, miscible with most organic solvents
Density: 1.618 g/cm³ at 20 °C
Partition Coefficient (Log Pow): Estimated 2.8–3.2

Stability and Reactivity

Stability: Stable under recommended storage and handling conditions
Incompatible Materials: Strong bases, strong oxidizers, strong acids
Conditions to Avoid: Heat, flames, sparks, exposure to moisture
Hazardous Decomposition Products: Hydrogen bromide, carbon oxides, other brominated compounds
Polymerization: Not known to undergo hazardous polymerization under normal conditions

Toxicological Information

Acute Toxicity: Oral LD50 (rats): estimated 500–2000 mg/kg; inhalation and dermal toxicity not fully characterized but may be harmful
Skin Corrosion/Irritation: Causes irritation on contact; prolonged exposure may cause burns
Serious Eye Damage/Irritation: Irritating on direct contact
Respiratory or Skin Sensitization: Limited evidence; sensitization possible with repeated exposure
Germ Cell Mutagenicity: Limited evidence from animal studies suggests mutagenic potential
Carcinogenicity: Not classified by IARC, OSHA, or NTP; insufficient data on cancer risks
Reproductive Toxicity: No specific studies available
Specific Target Organ Toxicity (STOT): May cause general systemic toxicity at higher exposures

Ecological Information

Ecotoxicity: Toxic to aquatic organisms by direct contamination; may cause long-term adverse effects in aquatic environments
Persistence and Degradability: Persistent in soil and water, degrades slowly by hydrolysis and microbial action
Bioaccumulative Potential: Moderate, calculated by log Pow
Mobility in Soil: Low to moderate; most will bind to organic matter or volatilize slowly
Other Adverse Effects: Harmful by-product risk through uncontrolled release, may disrupt local ecosystems

Disposal Considerations

Waste Disposal: Treat as hazardous chemical waste, do not pour down drain, incinerate in a chemical incinerator equipped with afterburner and scrubber in accordance with federal, state, and local regulations
Container Disposal: Rinse empty containers, dispose of in accordance with jurisdictional requirements; do not reuse or cut containers
Special Considerations: Avoid release to the environment, use licensed waste management company for off-site disposal

Transport Information

UN Number: UN 2810
UN Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains 1,6-Dibromohexane)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Labels: Toxic
Special Precautions: Ensure integrity of containers, segregate from incompatible materials, emergency response information must accompany shipment, comply with international and domestic transport regulations

Regulatory Information

Global Inventory: Listed on TSCA (USA), EINECS (EU), DSL (Canada), AICS (Australia)
Regulatory Status: Subject to hazardous chemical rules and regulations under OSHA in the USA, REACH in the EU, relevant global frameworks
Labelling Requirements: GHS classification and labeling required
Other Requirements: Risk and safety phrases, exposure controls, and restrictions may apply; users must follow workplace safety rules and provide employee training
Additional Guidance: Consult local, regional, and national authorities for further requirements on safe use, storage, and disposal