1,4-Dichlorobutane: Insight, Use, and Impact
Historical Development
1,4-Dichlorobutane came about as chemists looked for ways to build longer carbon chains with more reactive endpoints. The early chemical industry sought to modify butane in various ways, searching for intermediates with practical value. By chlorinating butane at two positions, researchers landed on a four-carbon molecule that would set the stage for a whole category of flexible syntheses. Over time, production methods improved, shifting from slow batch reactions to continuous processes. Chemical plants scaled up production, particularly in the 20th century, to meet growing industrial demand. This push for efficiency not only supported the expanding plastics and agrochemical sectors but also spurred new scientific discoveries about how to manipulate simple hydrocarbons and change their properties through targeted modification.
Product Overview
1,4-Dichlorobutane serves as a versatile building block in specialty chemical manufacturing. Its structure, two chlorines sitting at opposite ends of a four-carbon chain, means that this compound can easily connect to other molecules and form larger, more complex products. It shows up most often in the making of specialty polymers, drugs, and agricultural aids. Many companies rely on its predictable reactivity and handle it as a critical intermediate, a role that places it behind the scenes but essential to the function and profitability of entire industries.
Physical & Chemical Properties
This colorless liquid carries a faint, sweet odor—some describe it as similar to ether. Its boiling point sits around 161 °C, with a melting point close to -40 °C, showing it stays liquid at room temperature and in moderate cold. Given its relatively low density and modest vapor pressure, it doesn’t evaporate quickly but does need safe storage. Its two chlorine atoms make the molecule reactive toward nucleophiles, allowing efficient substitution reactions. Solubility in water is quite low, while miscibility in many organic solvents remains high, giving chemists a broad palette for mixing and reacting it with other ingredients.
Technical Specifications & Labeling
Producers focus on purity, often aiming for levels above 98% for industrial supply. Common labels list the CAS number—110-56-5—as well as hazard statements driven by regulatory bodies. Drums and bulk containers follow strict labeling rules, displaying UN numbers for transport safety. Manufacturers detail typical impurity profiles, moisture limits, and residual solvent content. These standards help buyers set up quality checks and prevent surprises downstream during polymerization or drug manufacturing. Some large-volume buyers even push for customized specs to match exacting requirements, highlighting just how much care goes into every shipment.
Preparation Method
Over the years, the chlorination of 1,4-butanediol or direct chlorination of butane under controlled light or temperature has become the go-to processes. The industry moved slowly from batchwise manufacture toward more continuous, closed-systems to minimize exposure and improve yields. By tweaking conditions—the amount of chlorine introduced, reaction time, and the role of catalysts—engineers wring out better conversion rates and fewer unwanted byproducts. Recovery and recycling of unreacted butane help keep costs under control, while purification—from distillation to selective extraction—removes any side products that might trip up sensitive applications.
Chemical Reactions & Modifications
As a bifunctional compound, 1,4-dichlorobutane acts as a key starting material for a wide range of chemical reactions. It undergoes nucleophilic substitutions, opening doors to diols, diamines, and nitrile derivatives—each serving as building blocks in other syntheses. For instance, reacting it with sodium cyanide yields 1,4-dicyanobutane, which becomes a precursor for polyamide polymers. Open both chlorines with ammonia, and you land on 1,4-diaminobutane, or putrescine, a central figure in nylon-4,6 synthesis. In the lab, chemists value this molecule for how cleanly it reacts, making for easy isolation of downstream products.
Synonyms & Product Names
Go through a chemical catalog, and you’ll spot 1,4-dichlorobutane listed as Tetramethylene dichloride, Butane-1,4-dichloride, or sometimes simply as DCB. International suppliers may use different language conventions, but the CAS designation offers a handy universal reference. These multiple names can trip up newcomers, so long-time chemists keep cross-indexes to ensure nothing gets lost in translation during procurement or safety checks.
Safety & Operational Standards
Everyone handling 1,4-dichlorobutane knows it presents both health and environmental risks. Direct skin contact can cause irritation, and inhalation brings respiratory concerns. Facilities lean on personal protective equipment—gloves, goggles, well-ventilated hoods—to manage exposure. Safe storage demands secure drums, away from strong acids, bases, and sources of ignition. Regular leak checks protect workers, and spill kits stand by. Regulations from OSHA, REACH, and similar bodies drive heavy reporting, and many sites require regular training to keep standards fresh in everyone’s mind. Disposal often routes through incineration, aiming to break down the persistent chlorinated molecules without sending toxins into the air or water. Companies that ignore these steps end up learning expensive, sometimes tragic, lessons about the need for rigorous health and safety.
Application Area
Polymer makers turn to 1,4-dichlorobutane for its straight C4 backbone, which fits perfectly into the synthesis of high-performance nylons and elastomers. Pharmaceutical research uses it as a molecular bridge, helping chemists fuse two different functional groups into one drug candidate. Agrochemical development taps its reactivity to build pesticides and herbicides with specialized activity. The electronics sector relies on specialty solvents and coatings derived from this molecule to meet needs for insulation and moisture resistance. For those working in material science and fine chemicals, the versatility of 1,4-dichlorobutane keeps it in regular rotation on the lab and plant bench.
Research & Development
Recent research has focused on greener production methods, targeting both process efficiency and environmental burden. Labs explore alternative chlorinating agents, biocatalysts, and even electrochemical synthesis to reduce hazardous waste. Others investigate ways to capture and recycle process off-gases, including unreacted chlorine, to close the loop. Analytical chemists develop sharper quality control systems to pick out trace contaminants, which matters more as end uses grow sensitive. As regulations get tougher and the downstream fields demand more precision, researchers look for ways to squeeze out every last gram of unwanted material and improve final product consistency. Beyond manufacture, ongoing innovation in functional derivatives points toward roles in new polymer platforms, custom surfactants, and advanced coatings that might shape the future of consumer products.
Toxicity Research
Exposure to 1,4-dichlorobutane presents notable risks to both humans and ecosystems. Acute toxicity studies show that high concentrations can depress the central nervous system, while chronic low-level exposure raises worries about possible liver or kidney impacts. Animal studies, some dating back decades, set the baseline for workplace guidelines but new research turns up gaps—especially around carcinogenicity and reproductive impacts. Surveys of groundwater and soil suggest that this molecule doesn’t break down easily, making careful handling and disposal critical to prevent contamination. Recent public health efforts push for stricter monitoring, and the chemical industry invests in cleaner processing and waste treatment. Both regulators and environmental groups keep a close watch, familiar with older stories of chlorinated solvent mishaps and determined not to repeat them.
Future Prospects
Demand for 1,4-dichlorobutane will likely track the wider chemical economy, seeing steady use in industrial manufacturing while facing rising expectations from regulators and downstream customers. The push for greener manufacturing shines a spotlight on plant emissions, energy intensity, and sustainable sourcing. Some researchers look for ways to replace it with less hazardous intermediates, but for now, its fit for purpose means it remains entrenched in multiple value chains. As plastics become more circular, and electronic devices ever more complex, the need for high-purity intermediates may drive more investment into advanced purification and waste minimization technology. Whether for innovation or compliance, success in managing this compound comes from a blend of technical know-how and forward-looking stewardship—balancing industry’s needs with the world’s growing concern for health and safety.
Why This Chemical Matters
1,4-Dichlorobutane flies under the radar for most people, but in labs and manufacturing plants, it’s a big deal. This colorless liquid pops up as a building block in chemical reactions. Its straight, four-carbon chain with chlorine atoms at both ends makes it particularly useful for creating more complex compounds. The pattern is simple but incredibly important for industries that rely on advanced synthetic chemistry.
Impact on Industry and Everyday Products
The main draw of 1,4-dichlorobutane is its role in making polymers and specialty chemicals. Factories count on it during the production of nylon-4,6, a type of nylon useful in engineering plastics. This tough material ends up in auto parts, electrical gadgets, and even sports equipment. Companies value nylon-4,6 because it stands up to high temperatures and holds its shape well under pressure. Think about automotive connectors, radiator parts, and electrical circuit components—these would not function the same without heat-resistant plastics made from intermediates like 1,4-dichlorobutane.
Pharmaceuticals also lean on this compound. While people may focus more on flashy clinical breakthroughs, few appreciate how important sturdy intermediates are. Chemical firms use 1,4-dichlorobutane to introduce specific carbon chains into drug molecules, which influence how medicines get absorbed and processed in our bodies. The difference between a life-saving medication and a failed drug attempt often sits with the reliable availability and consistency of these base chemicals.
Environmental and Safety Challenges
Handling 1,4-dichlorobutane is not without risks. Direct contact or inhalation causes irritation, and bigger spills bring hazards for both workers and the environment. Growing up around chemical plants in my hometown, I saw how lack of oversight and training led to real problems—accidents, exposures, long-term health issues. That’s one reason why chemical safety regulations matter so much. Making safer manufacturing spaces isn't just about checking boxes on a form; it’s about people with families, standing next to drums of materials like this one, needing real protection every day they come to work.
Disposal also poses headaches. Pouring chlorinated chemicals down the drain is reckless and illegal for good reason. Water treatment plants cannot break them down easily, letting persistent contamination spread. This has shown up near industrial sites in groundwater studies. Today’s best practice calls for incineration at high temperatures, a costly but necessary step for shutting the door on toxic byproducts.
Building a Safer Future
Some companies are starting to look for greener alternatives or new processes that produce less waste up front. Biobased chemistry might take years to catch up with the performance of traditional chemicals, but research keeps moving. In the meantime, investing in leak detection, proper ventilation, and worker training prevents small mistakes from turning into emergencies.
Strict tracking of chemical flows, transparent reporting, and community engagement keep chemical production sustainable. Customers ask questions about the entire supply chain now, not just the product itself. That creates incentives for chemical plants to rethink everything from raw material sourcing to final packaging and waste handling. The industry still faces big hurdles, but the push for cleaner, safer practices is stronger than ever. People recognize that even behind-the-scenes chemicals like 1,4-dichlorobutane can shape both our safety and the technologies that drive our lives.
Looking Risk in the Eye
1,4-Dichlorobutane catches the attention of any lab worker who’s spent hours around chemical shelves. Its place in synthesis can't be ignored, but the stuff packs hazards that you feel in the back of your mind while you’re pouring or sampling. No one wants to get splashed or inhale its vapors, because experience tells you things go downhill quick. It’s not paranoia—it’s memory, reinforced by real cases of skin burns and headaches, and even nasty respiratory irritation.
Personal Protection Always Comes First
I can still recall a time fresh out of school, gloves too big and a borrowed lab coat, watching an experienced chemist suit up just to open a bottle of 1,4-dichlorobutane. That lesson stuck: a layered defense matters more than any sense of overconfidence. Chemical-resistant gloves that fit right, not torn or old, keep hands clear of trouble. Working goggles hold out more than splashes and, paired with a well-zipped lab coat, protect against surprises. Inhaling vapors isn’t a gamble worth taking, so a fume hood or local exhaust isn't an option—it’s a line you don’t cross.
Ventilation: The Often Overlooked Guardrail
Whenever 1,4-dichlorobutane comes out, the fume hood should always be running. It's not about trusting your sense of smell, since vapors escape detection until it’s too late. Accidental spillage on an open bench might make rescue personnel mask up later. Anyone handling solvents long enough learns to trust the airflow, not luck. Routine checks on ventilation systems keep the hood trustworthy—for everyone, not just you.
Spill Management Isn’t Just a Checklist
Stories about scrambling for spill kits in the middle of a panic run close to home. Every workstation should sport a kit that’s actually stocked and ready. Absorbent pads, neutralizers (usually something for solvents, not acids), heavy-duty bags—none of these matter if hidden under boxes or behind dusty glassware. The key is a plan you rehearse, not one you invent on a bad day. Two people handle a spill faster—one keeps the area clear, and the other circles with cleanup tools. Bottles labelled with durable ink, never fading or peeling, prevent mix-ups in the flurry.
Storage and Waste: Out of Sight, Never Out of Mind
Improper storage accounts for too many emergency calls. Keeping 1,4-dichlorobutane in tightly sealed containers, away from sunlight or things that might trigger an unwanted reaction, means one less worry. Secondary containment trays mean that a leaking bottle doesn’t turn into an overnight disaster. Specific logs track every drop—pour-out, transfer, disposal—so you never reach back and wonder what’s inside the amber bottle. For disposal, relying on professional hazardous waste pickup keeps the temptation of “just pour it down the drain” out of the room.
Training Holds the Line
No shortcut substitutes real training. Group drills on spill response, detailed safety data sheet reviews, and regular walk-throughs of storage practices cut mistakes. When procedures run second nature, incidents drop. Talking with colleagues about near-misses also trumps any written reminder. I’ve seen habits improve tenfold after sharing stories, not just handing out protocols.
Final Word: Safety Is Real Life
Anyone who handles 1,4-dichlorobutane should see safety less as a rulebook and more as a fact of life. Good habits, sharp training, and solid gear build the only real buffer between routine work and a trip to the emergency room.
The Basics: Simple Chemistry, Real-World Impact
In high school, we ran across a handful of organic compounds with names that sounded like tongue twisters. 1,4-Dichlorobutane definitely landed on that list. Seeing students scribbling chemical structures, it became clear how easy it is to get lost without a solid understanding of what the formula means.
Understanding the Formula: C4H8Cl2
1,4-Dichlorobutane carries the formula C4H8Cl2. Four carbon atoms form a straight chain. The “1,4-dichloro” means each end of this chain picks up a chlorine atom, leaving the rest of the spots for hydrogen. That makes sense to me because growing up fixing things in the garage, I’d look at how things connect—one piece at each end holding everything together.
Where It Shows Up
People outside chemistry might not bump into 1,4-dichlorobutane daily, but it’s hiding behind the scenes more often than expected. Manufacturers use it to make specialty polymers and some types of synthetic rubber. It shows up as an intermediate chemical before getting reshaped into something entirely different—think of someone working wood, taking a plank and cutting, sanding, then painting it.
Health and Environmental Concerns
Handling chemicals like this demands respect. With two chlorine atoms hanging off a short carbon chain, 1,4-dichlorobutane brings certain risks. It can irritate eyes, skin, and the respiratory system. Research shared by the National Institute for Occupational Safety and Health warns that organochlorines often stick around longer in the environment than we’d like. During my stint working with household paints and solvents, we’d keep windows open and wear gloves, knowing what our bodies could absorb wasn’t always harmless. Many small companies have learned the hard way, watching a factory in the family neighborhood cause issues for streams and air.
Why It Matters
There’s a clear demand for innovative materials in almost everything built or repaired today—from automotive parts to insulation. The presence of 1,4-dichlorobutane in production chains isn’t just a technical note buried in textbooks. It matters because safer, better alternatives often hinge on understanding how every link in the supply chain fits together. In 2021, scientists and regulators highlighted that Europe and North America tracked industrial releases of organochlorines to limit groundwater contamination, showing real-world consequences linked to classroom chemistry.
Looking Toward Solutions
Cutting down on chemical hazards usually starts with education. Community colleges run safety courses from day one, drilling in the importance of proper handling, labelling, and storage. I’ve seen workplaces thrive when managers invest in safer ventilation and regular safety checks. There’s also a slow push for greener chemistry. Some new research explores swapping out chlorinated compounds with plant-based materials or developing processes that keep toxic byproducts out of rivers and landfills.
The big picture: learning the formula for a compound like 1,4-dichlorobutane goes far beyond memorizing a sequence of symbols. It opens the door to talking about what we make, how we use it, and most importantly, how we keep each other safe.
Experience Underscores Why Storage Choices Matter
The first time I worked alongside a chemical safety officer, the topic of 1,4-dichlorobutane came up almost as a cautionary tale. Too many labs treat chemicals as interchangeable commodities, but 1,4-dichlorobutane really serves as a reminder that a single oversight can be costly, not just in lost materials or fines, but sometimes in physical harm. This clear liquid may not shout “danger” like an acid or a compressed gas, but even mild exposure can lead to irritation. Consider that over time, if stored incorrectly, the consequences get worse. Respiratory issues, headaches, or burns are more likely if a leak happens in a stuffy room.
Temperature, Ventilation, and Compatibility Are Not Just Words
Ask anyone who’s spent nights monitoring a chemical storeroom after a power outage—temperature means everything. Leaving 1,4-dichlorobutane near a heat source isn’t a small mistake. Its relatively low boiling point means elevated temperatures encourage not only evaporation, but increased vapor concentration in the air, turning what should be a minor hazard into a very real risk for those nearby. I have witnessed cases where storing solvent bottles on an upper shelf, right above a radiator, led to leaking and sticky floors. For 1,4-dichlorobutane, a cool, stable environment below 25°C saves both headache and budget in cleanup or wasted stock.
Air toxicity rises as vapors collect in corners or cramped storage cabinets. Proper ventilation cuts that risk immediately. It shouldn’t take a near miss with a vapor cloud before someone installs a fume exhaust. A basic flow of fresh air keeps concentrations well below occupational exposure limits. What’s the point in training on emergency procedures if stale air makes accidents inevitable from the start?
Compatibility Keeps Fumes and Fire Away
Look at the safety data for 1,4-dichlorobutane, and it’s clear—don’t store it with strong oxidizers or acids. It’s tempting to cram flammable liquids together to “save space”, yet the smallest reaction can set off a chain of hazards nobody wants to clean up. Even in small facilities, chemical organization takes priority over convenience. Color coding or physical barriers between incompatible chemicals pays for itself on days when something cracks or tips over.
Material choices for containers are just as critical. I remember watching a new technician pour solvent into a plastic bottle that slowly became soft overnight. The label on 1,4-dichlorobutane recommends glass or compatible plastics, and for good reason—some plastics degrade or leach, making contamination a hidden threat until testing finds out. No one enjoys tracing a strange lab result back to corner-cutting with bottles.
Respect the Label, But Don’t Rely on It Alone
Regulatory labels give warnings, but hands-on vigilance protects more effectively. Sealed, clearly labeled containers help, but anyone sharing storage space needs regular walk-throughs—physical checks, not just clipboard ticks. Over time, even tiny leaks or outdated stock add up to bigger problems. Trying to save time in the short run nearly always brings regrets down the line.
1,4-dichlorobutane isn’t the most dangerous chemical in the storeroom. Yet poor storage habits with any solvent eventually invite trouble. Communities, workers, and families trust that we follow best practices. That’s a responsibility you feel deeply the first time a safety measure you fought for keeps a near-miss from turning tragic.
Form, Smell, and Color
Anyone working with 1,4-Dichlorobutane learns to respect its nature early on. The chemical looks like a clear, colorless liquid. You won’t see much color or cloudiness in a typical sample. Open a container and you catch a sharp, somewhat sweet odor, not unlike other chlorinated solvents. The smell warns you: this isn’t something to splash around or sniff up close.
Boiling and Freezing Points
Temperature matters a lot in labs and factories. 1,4-Dichlorobutane boils around 161 degrees Celsius (322 degrees Fahrenheit). That temperature gives a clue: it doesn’t just evaporate off a desktop at room temperature. People who’ve tried distilling or evaporating it know it needs a fair bit of heating. Its freezing point slides in lower than many household chemicals — about -40 degrees Celsius — so keeping it stored in cold climates won’t always turn it solid.
Density and Solubility
Pour some into a beaker and you’ll notice it’s heavier than water. Its density, roughly 1.16 grams per cubic centimeter, means it settles on the bottom if tipped into a glass of water. Most water-based cleaners won’t touch it. In practice, this chemical avoids dissolving in water, preferring to mix with things like alcohol, ether, and other organic solvents. Try rinsing it off with water and you end up smearing it instead of washing it away. That’s a headache for clean-up, but a plus in synthesis when you want a nonpolar environment.
Practical Safety Concerns
Properties tell a story about safe handling. With a vapor pressure of just a few millimeters of mercury at room temperature, this compound creates some vapor, but not so much you’d see clouds. Still, inhaling it day after day leads to headaches, dizziness, and more. Safety sheets push for fume hoods and gloves—and from experience, skipping protection leads to trouble. The flash point, clocking in at 51°C (124°F), makes it flammable enough if left near a heat source but not as risky as lighter solvents.
What Physical Properties Mean for Industry
Factories using 1,4-Dichlorobutane don’t pick it for looks or smell—they value that boiling point, density, and low water solubility. These traits suit certain chemical syntheses, like making pharmaceuticals or specialty plastics. But these same qualities—the persistence as a liquid, tendency to hang around on surfaces, resistance to water—pose environmental challenges. Any spill seeps into the ground and lingers. Traditional water-based remediation doesn’t cut it.
Better practices can limit those headaches. Closed transfer systems and secondary containment keep waste and spills away from drains and soil. Substitution isn’t always practical, but tight controls and real-time monitoring lower risks. Responsible disposal, checking for leaks, and thinking ahead before scaling up keeps harm away from workers and neighbors alike.
Looking Forward
Anyone handling 1,4-Dichlorobutane faces trade-offs. Those physical properties—clear liquid, dense, resistant to water—offer utility but demand respect. Good training, strict protocols, and steady investment in safety tech help maintain benefits while driving down health and environmental costs. New research into greener synthesis routes and better cleanup breaks the link between chemical utility and contamination. Day to day, that boils down to knowing what you’re working with and never underestimating what a clear, sharp-smelling liquid can do if left unchecked.


| Names | |
| Preferred IUPAC name | 1,4-dichlorobutane |
| Other names |
1,4-DCB
Tetramethylene dichloride Tetramethylenedichloride 1,4-Butylene chloride Tetramethylene chloride Tetramethylenchlorid |
| Pronunciation | /ˈwaɪn fəʊ ˈdaɪklɔːrəˌbjuːˈteɪn/ |
| Identifiers | |
| CAS Number | 110-56-5 |
| Beilstein Reference | 1721363 |
| ChEBI | CHEBI:142562 |
| ChEMBL | CHEMBL137060 |
| ChemSpider | 7093 |
| DrugBank | DB01914 |
| ECHA InfoCard | 03af75b9-f27c-4a66-97e0-725082c8c3f3 |
| EC Number | 203-427-2 |
| Gmelin Reference | 10922 |
| KEGG | C01782 |
| MeSH | D003982 |
| PubChem CID | 8035 |
| RTECS number | EK9625000 |
| UNII | W4T4XT6BWT |
| UN number | UN2529 |
| Properties | |
| Chemical formula | C4H8Cl2 |
| Molar mass | 127.01 g/mol |
| Appearance | Colorless liquid |
| Odor | Mildly pungent |
| Density | 1.18 g/mL at 25 °C(lit.) |
| Solubility in water | Moderately soluble |
| log P | 1.98 |
| Vapor pressure | 3.57 mmHg (at 25 °C) |
| Acidity (pKa) | 14.71 |
| Magnetic susceptibility (χ) | -7.71e-6 |
| Refractive index (nD) | 1.450 |
| Viscosity | 1.712 mPa·s (20 °C) |
| Dipole moment | 2.20 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 276.6 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -146.2 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -2776.2 kJ/mol |
| Hazards | |
| GHS labelling | GHS02, GHS07 |
| Pictograms | GHS02,GHS07 |
| Signal word | Warning |
| Hazard statements | H225, H302, H312, H315, H319, H332 |
| Precautionary statements | P210, P280, P305+P351+P338, P310, P501 |
| NFPA 704 (fire diamond) | 1,2,0 |
| Flash point | 62 °C |
| Autoignition temperature | 215 °C |
| Explosive limits | 3.5–17.6% |
| Lethal dose or concentration | LD50 oral rat 2500 mg/kg |
| LD50 (median dose) | LD50 (median dose): Oral rat LD50 = 570 mg/kg |
| NIOSH | KL8575000 |
| PEL (Permissible) | Not established |
| REL (Recommended) | 5 ppm (18 mg/m³) |
| IDLH (Immediate danger) | 75 ppm |
| Related compounds | |
| Related compounds |
1,2-Dichlorobutane
1,3-Dichloropropane 1,5-Dichloropentane 1,4-Butanediol 1,4-Dibromobutane Butane |