1,3-Dibromopropane: An In-Depth Commentary
Historical Development
The journey of 1,3-dibromopropane traces back to early bromination experiments of the nineteenth century. Early chemists learned to handle bromine with care, recognizing both its aggressive reactivity and potential for breakthroughs in organic transformations. By the 1930s, commercial labs in Europe and the United States began producing dibrominated hydrocarbons, including 1,3-dibromopropane, to support the growing rubber and pharmaceutical industries. This chemical earned attention because it allowed direct access to three-carbon chains flanked by reactive sites, helping synthetic chemists link and modify molecules. Many foundational textbooks described its use when discussing the practical challenges of introducing bromine atoms into alkanes, and its systematic production soon enabled wider use across both academia and industry.
Product Overview
1,3-Dibromopropane stands out as a specialty chemical, recognized more for its value in synthesis than everyday consumer goods. Most users are not going to see 1,3-dibromopropane on a high street shelf; instead, they encounter it in labs, workshops, and factories where intermediates feed into everything from fragrances to complex pharmaceutical scaffolds. Its unique ability to serve as both a building block and a functional modifier makes it more flexible than simpler brominated alkanes.
Physical & Chemical Properties
Clear, colorless, and carrying a distinct odor, 1,3-dibromopropane demonstrates moderate density, usually hovering around 2.13 g/cm³. Its boiling point sits near 196°C, giving it a fair degree of stability under ordinary conditions, but not enough to avoid loss if left open during vigorous heating. As a dihalide, its two bromine atoms rest at either end of the propane chain, giving it symmetrical reactivity. Its solubility leans toward organic solvents, making water an unlikely match in practice. Flammability remains low, but the irritation risk from inhalation or skin contact encourages careful storage and usage.
Technical Specifications & Labeling
A standard technical datasheet for 1,3-dibromopropane states a minimum purity, usually upwards of 98%. Moisture and acidity contents stay tightly regulated due to their impact on reactivity. The CAS number 109-64-8 typically marks any legitimate bottle, alongside warnings about skin, eye, and respiratory irritation. Safety pictograms highlight hazards for acute toxicity and environmental persistence. Any supplier worth partnering with tests batches for heavy metal content, color, and refractive index, detailing these results on the label to prevent surprises in downstream applications.
Preparation Method
Lab and factory technicians use direct bromination of propan-1-ol or allyl alcohol, often followed by purification through distillation. Hydrogen bromide addition to allyl bromide provides a route with better selectivity, especially in facilities able to tightly control reaction pressure and temperature. Some researchers favor a two-step process from propane via chlorination and subsequent halogen exchange, but industrial producers remain drawn to lower-cost raw materials and fewer synthesis steps. Quality control at each stage keeps unwanted byproducts out, a lesson learned through expensive recalls in the early years.
Chemical Reactions & Modifications
Chemists use 1,3-dibromopropane as a gateway to more elaborate molecules. Nucleophilic substitution comes easy, as the bromine atoms yield to amine or thiol attacks, making it a natural crosslinking agent or chain extender. Its backbone welcomes Grignard reagent formation, allowing synthetic teams to seek alcohols, acids, and other functionalities using familiar transformations. Beyond classic substitutions, some labs pursue controlled eliminations to shift the molecule into vinyl bromides, which serve as handles for further coupling reactions in more advanced syntheses.
Synonyms & Product Names
Not everyone calls it 1,3-dibromopropane. Look for names like trimethylene dibromide or propane, 1,3-dibromo- on international shipments or publication records. The CAS number 109-64-8 unites chemists regardless of language, but local regulations sometimes refer to it by systematized vocabulary from European or North American agencies.
Safety & Operational Standards
Lab managers stress the need for gloves, eye protection, and hoods whenever opening a bottle of 1,3-dibromopropane. Reports from occupational health researchers show repeated contact leads to dermatitis and, at higher doses, respiratory distress. Handling guidelines from organizations like OSHA and REACH demand clear labeling, ventilation, and emergency spill response procedures. Anybody transporting it across borders faces routine scrutiny, as some jurisdictions classify this molecule as potentially hazardous waste after use. Positive pressure respirators, spill kits, and chemical showers anchor any facility’s toolkit for working with this and similar alkyl dihalides.
Application Area
Application stretches far beyond a single industry. Custom chemical manufacturers feed it into pharmaceuticals, especially as a linker in the creation of active small molecules. Rubber and plastic engineers use crosslinking routes to generate materials with boosted durability or unique flexibility. Fragrance chemists seize on its chain-building talents to stretch and anchor aromatic rings, helping create longer-lasting scents. In the research world, it crops up in all sorts of method development, screening new reactions or preparing reference samples for analytic methods.
Research & Development
Academic and corporate teams look for greener synthesis routes, less hazardous alternatives, and broader functional group compatibility. Electrochemical methods and alternative energy inputs attract attention, promising lower emissions and fewer toxic byproducts. Labs publish new ways to coax selectivity from old reactions, turning 1,3-dibromopropane into more exotic targets with fewer purification headaches. Collaborative projects involving digital modeling and automation stretch resources further, making these old-school chemicals serve modern science with increased efficiency.
Toxicity Research
Toxicologists have tested 1,3-dibromopropane across multiple systems. Inhalation and chronic skin contact both cause tissue irritation, sometimes escalating to more serious health effects at repeated or high exposure levels. Environmental studies document slow biodegradation, so any large-scale escape needs rapid intervention to protect waterways and soil. Animal data in high doses recorded nervous system impacts, placing it on lists of chemicals to handle with elevated caution. Regulators continue to track long-term data, pressing for improved personal protective equipment and rigorous workplace monitoring.
Future Prospects
The landscape continues to change. Firms keep searching for bio-based feedstocks or catalysts to streamline 1,3-dibromopropane production. Synthetic chemists combine digital planning tools with classic chemistry, reaching molecules that took much longer a generation ago. Regulatory shifts could limit or reshape applications, but innovation around safety and cleaner, faster methods helps hold a place for this compound in the chemical toolbox. The push for sustainability will force a reevaluation of legacy processes, opening avenues for next-generation materials and pharmaceuticals anchored by smart use of all building blocks on hand.
From the Lab Bench to Real-World Products
1,3-Dibromopropane rarely makes headlines, but the chemical’s potential stretches across research and production environments. Its formula is simple—three carbon atoms in a row, with a bromine atom hanging on each end. Chemists appreciate this structure because it provides two reactive points, making it a strong candidate for constructing more complicated molecules. If you spend any time around a lab, you notice how often these basic building blocks pop up in textbooks and experiments. Here’s a look at how those clear bottles labeled 1,3-Dibromopropane show up in practice.
Creating Value Through Synthesis
University labs and pharmaceutical companies often lean on 1,3-dibromopropane as a tool for making new compounds. Its two bromine atoms can get swapped out pretty easily, which makes it valuable in organic synthesis. For example, researchers looking to build a custom drug molecule—or tweak an existing one—can use it to add a chain where it’s needed. In my college days, I saw postdocs using it to make intermediate chemicals that later became more useful products. It’s a little like using a connector in a LEGO set—without it, the rest of the structure wouldn’t hold together.
In teaching and demonstration settings, instructors rely on this chemical to show how substitution and addition reactions work. Reactions involving 1,3-dibromopropane help students see the importance of leaving groups and nucleophiles in real time. The hands-on understanding carries over into industrial labs, where experienced chemists develop catalysts, polymers, and active pharmaceutical ingredients.
Making Polymers and Specialty Materials
1,3-Dibromopropane lands in the world of polymers. Manufacturers sometimes use it as a cross-linking agent. By bridging polymer chains, it gives a material more strength or new properties. Think about wires wrapped in insulated materials or coatings that shield devices in challenging environments. A better backbone at the molecular level leads to longer-lasting products in the world outside the factory. I toured an electronics plant once, and the engineers weren’t just swapping out parts—they talked about how a tweak in the chemical recipe for an insulating material, sometimes involving simple molecules like 1,3-dibromopropane, could keep thousands of devices running longer and safer.
Environmental and Safety Considerations
With brominated chemicals like this, responsible handling matters. Any substance that can help build drugs or durable plastics gets attention for two reasons: potential environmental risks and worker exposure. Studies suggest that bromine-based chemicals don’t break down very easily in nature. Accidental spills or improper disposal reach waterways and stick around. Several health agencies encourage producers and researchers to use small amounts, wear protective gear, and monitor workplace air for contamination. Guidelines call for special storage and prompt cleanup of any leaks.
Moving Forward With Better Oversight
The trend is shifting toward using alternatives or reducing bromine-based reagents when possible. Green chemistry principles suggest using less hazardous substances and recycling wherever practical. In college labs, we started practicing “microscale” experiments to minimize leftover chemicals and cut back on waste. Industry leaders continue to introduce new protocols and technologies to recycle solvents and capture trace emissions. Over time, push for safety and greener chemistry points the way to developing new methods that rely less on legacy chemicals like 1,3-dibromopropane.
Understanding 1,3-Dibromopropane at Its Core
Chemistry class back in high school never painted a picture of molecules beyond ball-and-stick models. Years later, looking at 1,3-dibromopropane, I see more than a collection of atoms; it reminds me how something simple drives progress in medicine, industry, and research. The molecular formula for 1,3-dibromopropane stands as C3H6Br2. It packs three carbon atoms, six hydrogens, and two bromine atoms. It seems straightforward. Yet, that arrangement tells a bigger story about how basic building blocks spawn new compounds, and in turn, solutions for the world’s toughest problems.
Why 1,3-Dibromopropane Matters
Organic chemistry rests on forming and breaking bonds. To see the importance of this molecule, think about what happens in a lab. The two bromine atoms latch onto the first and third carbon atoms in the propane chain. This unique setup acts like a handhold for chemists, letting them swap out bromine for other functional groups. In the pharmaceutical world, researchers lean on 1,3-dibromopropane as a starting point for more complex medication ingredients. It opens pathways to synthesize antifungal and antibacterial agents. I once visited a startup fighting crop blight; they use this compound as an intermediate during pesticide production.
Some see chemical formulas as puzzle pieces, but those pieces shape everything from new drugs to sustainable plastics. Given the global push for greener chemistry, clarity on molecular makeup goes beyond memorizing symbols—people need to see how 1,3-dibromopropane unlocks different routes to more eco-friendly alternatives or safer materials. Watching scientists build custom molecules starting with C3H6Br2 tells me every atom matters.
Fact-Driven Perspectives
A 2022 report from the Royal Society of Chemistry highlights the growth in demand for dibromoalkanes driven by rising use in the pharmaceutical sector. Safety remains a top concern, as accidental exposure to halogenated hydrocarbons like 1,3-dibromopropane can harm human health. Proper protocols in labs and production sites keep researchers and workers safe. The Environmental Protection Agency monitors synthetic intermediates such as these, making sure manufacturers comply with health and safety regulations.
In my own experience, handling 1,3-dibromopropane in a college lab pushed everyone to double-check gloves and work under a fume hood. It’s not enough to know a formula; respecting the compound’s power, both as a chemical tool and potential hazard, changes how people work and teaches accountability. Real responsibility ties back to understanding both the formula and its impact.
Charting a Better Path Forward
While synthetic chemistry advances, safer alternatives draw more attention. Green chemistry protocols push for minimizing hazardous waste. Researchers have started exploring catalysts and processes that avoid dibrominated intermediates when possible. Replacing heavier halogens or designing bio-based pathways could reduce health risks and environmental impact, but this demands investment and open-mindedness from both academia and industry.
Everyone involved with 1,3-dibromopropane—whether in a lab, a factory, or a classroom—needs clear education on handling and disposal. I’ve seen firsthand how robust training programs make the difference, not just for lab workers but also for communities living near production plants. If the story of C3H6Br2 teaches anything, it’s that knowledge, coupled with respect and innovation, paves the way for chemistry that improves lives, not just formulas on a page.
The Facts About 1,3-Dibromopropane
Working in chemistry labs for several years, I’ve noticed that some chemicals draw more scrutiny than others. 1,3-Dibromopropane isn’t a household name, but it pops up often on safety data sheets. Made from bromine and propane, this clear liquid carries a sharp odor and finds use in organic synthesis. It doesn’t end up in consumer products, but its presence in the industrial world deserves real attention.
Health Risks You Can’t Ignore
Safety never comes from just reading manuals. Inhaling vapors or touching the skin can lead to burns, irritation, or worse—because 1,3-dibromopropane acts as both a skin and respiratory irritant. Exposed workers often need goggles, gloves, and sometimes even respirators just to handle a bottle. The eyes will water, and even the best ventilation won’t stop that choking feeling if a bottle spills. The compound clings to surfaces, so cross-contamination happens fast unless you’re vigilant about cleanup. I recall a coworker who underestimated this and learned firsthand how far the fumes can drift through a shared work area.
Looking deeper into the research, animal studies link long-term exposure to serious health problems like organ damage and potential genetic effects. These studies aren’t perfect reflections of human workplaces but raise real red flags. Regulations from Europe and the US confirm that this isn’t something for casual use. Allowable exposure levels stay low, since nobody knows the safe margin for long stretches of contact.
Environmental Impact Takes a Back Seat
People rarely talk about how these types of chemicals disrupt more than just a workspace. Even small spills run downhill, and 1,3-dibromopropane doesn’t break down fast. The compound can seep into water systems, risking contamination for plants and wildlife long after people pack up for the day. The EPA classifies it as a hazardous substance, partly because of this stickiness in the environment. Incineration and controlled disposal stand as the best bets for keeping it out of the local river, but these methods cost time and money—two things that get short shrift in tight budgets.
What Can Be Done?
Top-down rules help, but experience in the field says that nothing beats daily vigilance. Personal protective equipment saves skin, but not everyone gets steady training on why it matters. Regular drills, clear signage, and lots of communication—these all work better than just hoping people read every label. On the disposal end, bundling chemical shipments and planning routes can nip risk in the bud before a bottle ever leaves the warehouse. Manufacturers could invest in safer substitutes where possible, pressing suppliers for chemicals with fewer long-term hazards. Sometimes it comes down to worker empowerment: anyone, from janitors to chemists, should have the freedom to halt a job if they spot a leak or smell a whiff of something nasty. That kind of shared responsibility creates a safer space for everyone.
Looking Forward
From what I’ve seen in industrial labs and reviewed in scientific literature, 1,3-dibromopropane brings plenty of baggage. The risks aren’t just theoretical. It demands respect from everyone who works near it. Following regulations, educating staff, and verifying disposal methods make a big difference. Nobody wants to become the cautionary tale written up later, so treating this compound with caution feels like the only smart move.
Understanding What 1,3-Dibromopropane Brings to the Table
1,3-Dibromopropane has a reputation for being flammable, irritating, and somewhat unpredictable if left unchecked. Its strong, almost sweet odor has a way of hanging in the air, especially in spaces without good ventilation. Chemical manufacturers rely on it for synthesis, but just like with other brominated hydrocarbons, making a mistake with storage carries big risks.
Keeping Temperature and Sunlight in Check
Heat and direct sun spell trouble. This liquid likes stable, cool temperatures—room temperature fits, but higher ambient heat can mean increased vapor buildup. Heat or sunlight can degrade the compound, leading to pressure buildup inside storage drums or bottles. Laboratories often use temperature-monitored cabinets. Keeping away from boiler rooms, radiators, or any surface that gets warm is the smart move.
Why Airflow and Ventilation Matter
Stale, stagnant air leads to vapor accumulation, which ramps up the risk of inhalation or explosions. Storage rooms with working ventilation systems are non-negotiable. Every chemist who’s spent time in a stockroom knows the smell in the air is the first sign things are wrong. Good airflow means less chance of vapors reaching dangerous levels or drifting into other parts of a facility.
No Room for Sparks or Flames
Some substances can get by with basic precautions. 1,3-Dibromopropane doesn’t cut corners. Sources of ignition—open flames, static electricity, poorly maintained wiring—turn a minor leak into a disaster. That’s why storage happens in designated chemical storage rooms with spark-proof lighting and electrical components rated for hazardous materials. In smaller labs, flammable liquid cabinets shield the contents from outside heat and accidental sparks.
Compatible Containers and Durable Labels
Improper containers lead to leaks, corrosion, and confusion. Thick glass bottles with chemical-resistant stoppers are a staple. HDPE plastic sometimes enters the mix, but routine checks are essential, as strong chemicals eat through weaker plastics over time. Clear labeling with the product name, hazard warnings, and date of receipt reduces mistakes. A handwritten label or faded printout spells trouble down the line—especially if a spill demands a quick, informed response.
Hazards of Mixing and Placement
Storage isn’t just about where the bottle sits—it’s about what’s nearby. 1,3-Dibromopropane reacts poorly around strong bases, oxidizers, and certain metals. Acids and alkalis belong on different shelves. Mixing mistakes in cramped cabinets have sent more than one chemist to the emergency room. Separation by hazard class takes planning up front, but after years in the lab, I’ve seen that a little effort cuts panic and accidents down the road.
Emergency Equipment and Handling Procedures
No storage setup means much without backup plans. Spill kits, eyewash stations, and emergency showers sit within arm’s reach of storage areas. Staff training goes hand in hand with secure storage—knowing how to respond to leaks or overexposure saves lives. Even the best systems fail under pressure, but preparation limits the fallout.
The Real Picture: Diligence Over Routine
Chemicals like 1,3-Dibromopropane demand respect. They don’t forgive shortcut storage practices. The real work lies in sticking to safety routines, keeping an eye out for container wear, and refreshing safety training long before accidents force the issue. Better storage starts with recognizing that convenience never beats safety where these compounds are concerned.
Getting Familiar with 1,3-Dibromopropane
Once in a while, a chemical grabs your attention—not because it’s dramatic, but because understanding it brings a little clarity to everyday science. 1,3-Dibromopropane is one of those compounds. You’re looking at a clear, colorless liquid, often pulled out as a starting material for organic synthesis or specialty chemical research. It doesn’t show up in headlines much, yet its physical behavior matters in labs, classrooms, and industries.
Let’s dive into something concrete: the boiling point of 1,3-dibromopropane. Around 196 degrees Celsius is the number you’ll find in reliable chemical databases, including trusted sources like PubChem and ChemicalBook. This temperature means it stands firm against evaporation at room temperature. Students and professionals in chemistry rely on that number during purification or distillation. From experience, seeing an error in the boiling point can wreck hours of lab work—solvent recovery gets botched, and yields drop.
Why Boiling Points Matter Beyond Textbooks
A chemical’s boiling point isn’t just trivia. It tells a lot about safety, storage, and handling. Think about containment, for example. 1,3-Dibromopropane’s temperature requirement for boiling means regular glass containers work fine for storage, but when it’s time to distill or purify, handling needs caution. In my own time in teaching labs, one overlooked temperature reading or an unexpected pressure change pushed students into cleanup mode, scrambling for fume hoods and fresh gloves.
Facts back up those personal knocks. According to the National Institute for Occupational Safety and Health (NIOSH), temperature affects the vapor pressure and toxicity of chemicals. At higher temperatures, vapor gets into the air quicker, which boosts chances for exposure. Even without visible fumes, breathing them for long isn’t good news. Labs ensure the right ventilation and follow recommended boiling points because experience says a small slip brings health risks or expensive chemical loss.
Learning From the Numbers
A 196°C boiling point, pretty high for a liquid, hints at the strength of those carbon-bromine bonds and the way the molecule clings to itself at the surface. That has practical uses. Industrial workers use 1,3-dibromopropane in organic synthesis precisely because it sits in a middle range—not as volatile as acetone, not as sticky as heavy oils. Researchers pick chemicals with a matching boiling point when setting up reaction chains. For those doing distillation or trying to reclaim solvents, this property shapes the game plan.
In fields pushing for greener labs, boiling points also nudge choices about energy use. A higher boiling compound needs more heat, which means more power and better equipment. Companies now look at this closely with sustainability goals, and chemists debate whether there’s value in swapping a compound for another with similar chemical behavior but lower environmental impact.
Building Good Habits Around Handling
Handling 1,3-dibromopropane brings up bigger lessons beyond its boiling point. Labels on chemical bottles warn about skin, eye, and lung irritation, and that’s not empty legalese from the supplier. I’ve come across cases where colleagues relaxed safety steps since the liquid felt heavy and slow to evaporate. It feels counterintuitive, but even high-boiling compounds slip into the air with enough heat or over long storage. Air monitoring, hoods, and gloves matter regardless of how “safe” a temperature sounds.
It’s never just about memorizing numbers. The boiling point serves as a warning and a tool—reminding chemists, teachers, and students of the delicate balance between control and chaos in a well-run lab. Chemistry rewards those who respect the properties of the materials in front of them.


| Names | |
| Preferred IUPAC name | 1,3-dibromopropane |
| Other names |
Trimethylene dibromide
Propane, 1,3-dibromo- Trimethylene bromide 1,3-Prdibromopropane |
| Pronunciation | /ˈwʌnˌθri daɪˌbroʊmoʊˈproʊpeɪn/ |
| Identifiers | |
| CAS Number | 109-64-8 |
| Beilstein Reference | 1209286 |
| ChEBI | CHEBI:41241 |
| ChEMBL | CHEMBL50194 |
| ChemSpider | 68210 |
| DrugBank | DB08135 |
| ECHA InfoCard | 03e0b8e1-184c-4549-989c-56eda404c6be |
| EC Number | 203-696-6 |
| Gmelin Reference | 8229 |
| KEGG | C00675 |
| MeSH | D003977 |
| PubChem CID | 8035 |
| RTECS number | EK8575000 |
| UNII | 6VTJ7J89E6 |
| UN number | UN1993 |
| Properties | |
| Chemical formula | C3H6Br2 |
| Molar mass | 201.94 g/mol |
| Appearance | Colorless to light yellow liquid |
| Odor | Sweet odor |
| Density | 2.033 g/mL at 25 °C(lit.) |
| Solubility in water | slightly soluble |
| log P | 1.98 |
| Vapor pressure | 0.8 mmHg (20 °C) |
| Acidity (pKa) | 13.2 |
| Magnetic susceptibility (χ) | -7.62×10⁻⁶ |
| Refractive index (nD) | 1.488 |
| Viscosity | 1.679 cP at 25 °C |
| Dipole moment | 2.60 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 216.6 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -44.9 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -3680.6 kJ·mol⁻¹ |
| Hazards | |
| GHS labelling | GHS02, GHS07 |
| Pictograms | GHS02,GHS07 |
| Signal word | Warning |
| Hazard statements | H302, H315, H319, H332, H335 |
| Precautionary statements | P210, P261, P280, P301+P310, P304+P340, P305+P351+P338, P311, P330, P403+P233 |
| NFPA 704 (fire diamond) | 1-2-0 |
| Flash point | 86 °C |
| Explosive limits | Explosive limits: 2.8–13% |
| Lethal dose or concentration | LD50 oral rat 910 mg/kg |
| LD50 (median dose) | LD50 (median dose): 3,400 mg/kg (oral, rat) |
| NIOSH | Not established |
| PEL (Permissible) | Not established |
| REL (Recommended) | 1 ppm |
| IDLH (Immediate danger) | Unknown |
| Related compounds | |
| Related compounds |
1,2-Dibromopropane
1-Bromopropane 3-Bromopropene 1,3-Dichloropropane 1,3-Diiodopropane 1,3-Dibromo-2-propanol |